Assessment of Structural Intolerance and Durability
General Structure Information 3ff3 NAALAD2 the high resolution structure of human glutamate carboxypeptidase iii (gcpiii/naaladase ii) in complex with l-glutamate 1.37Å AUTH K.HLOUCHOVA,C.BARINKA,J.KONVALINKA,J.LUBKOWSKITITL STRUCTURAL INSIGHT INTO THE EVOLUTIONARY AND PHARMACOLOGICTITL 2 HOMOLOGY OF GLUTAMATE CARBOXYPEPTIDASES II AND IIIREF FEBS J. V. 276 4448 2009REFN ISSN 1742-464XPMID 19678840DOI 10.1111/J.1742-4658.2009.07152.X Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4ael PDE10A pde10a in complex with the inhibitor az5 2.2Å AUTH U.BAUER,F.GIORDANETTO,M.BAUER,G.OMAHONY,K.E.JOHANSSON,AUTH 2 W.KNECHT,J.HARTLEIB-GESCHWINDNER,E.T.CARLSSON,C.ENROTHTITL DISCOVERY OF 4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILETITL 2 DERIVATIVES AS NOVEL PDE10A INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 22 1944 2012REFN ISSN 0960-894XPMID 22321214DOI 10.1016/J.BMCL.2012.01.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3h3s COL4A3BP crystal structure of the cert start domain in complex with hpa-15 1.66Å AUTH N.KUDO,K.KUMAGAI,R.MATSUBARA,S.KOBAYASHI,K.HANADA,AUTH 2 S.WAKATSUKI,R.KATOTITL CRYSTAL STRUCTURES OF THE CERT START DOMAIN WITHTITL 2 INHIBITORS PROVIDE INSIGHTS INTO THE MECHANISM OFTITL 3 CERAMIDE TRANSFER.REF J.MOL.BIOL. V. 396 245 2010REFN ISSN 0022-2836PMID 20036255DOI 10.1016/J.JMB.2009.12.029 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3e77 PSAT1 human phosphoserine aminotransferase in complex with plp 2.5Å AUTH L.LEHTIO,T.KARLBERG,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,AUTH 3 A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,M.MOCHE,M.E.NILSSON,P.NORDLUND,T.NYMAN,K.OLESEN,AUTH 5 C.PERSSON,J.SAGEMARK,S.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,J.WEIGELT,AUTH 7 H.SCHUELER,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL HUMAN PHOSPHOSERINE AMINOTRANSFERASE IN COMPLEX WITH PLPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2nyt APOBEC2 the apobec2 crystal structure and functional implications for aid 2.5Å AUTH C.PROCHNOW,R.BRANSTEITTER,M.G.KLEIN,M.F.GOODMAN,AUTH 2 X.S.CHENTITL THE APOBEC-2 CRYSTAL STRUCTURE AND FUNCTIONALTITL 2 IMPLICATIONS FOR THE DEAMINASE AID.REF NATURE V. 445 447 2007REFN ISSN 0028-0836PMID 17187054DOI 10.1038/NATURE05492 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3enp TPRKB crystal structure of human cgi121 2.48Å AUTH D.Y.MAO,D.NECULAI,M.DOWNEY,S.ORLICKY,Y.Z.HAFFANI,AUTH 2 D.F.CECCARELLI,J.S.HO,R.K.SZILARD,W.ZHANG,C.S.HO,L.WAN,AUTH 3 C.FARES,S.RUMPEL,I.KURINOV,C.H.ARROWSMITH,D.DUROCHER,AUTH 4 F.SICHERITITL ATOMIC STRUCTURE OF THE KEOPS COMPLEX: AN ANCIENT PROTEINTITL 2 KINASE-CONTAINING MOLECULAR MACHINE.REF MOL.CELL V. 32 259 2008REFN ISSN 1097-2765PMID 18951093DOI 10.1016/J.MOLCEL.2008.10.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4akm LAMP3 crystal structure of the human lysosome-associated membrane protein lamp-3 (aka dc-lamp) 2.69Å AUTH S.WILKE,J.KRAUSZE,K.BUSSOWTITL CRYSTAL STRUCTURE OF THE CONSERVED DOMAIN OF THE DCTITL 2 LYSOSOMAL ASSOCIATED MEMBRANE PROTEIN: IMPLICATIONS FOR THETITL 3 LYSOSOMAL GLYCOCALYX.REF BMC BIOL. V. 10 62 2012REFN ISSN 1741-7007PMID 22809326DOI 10.1186/1741-7007-10-62 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2yhw GNE high-resolution crystal structures of n-acetylmannosamine kinase: insights about substrate specificity, activity and inhibitor modelling. 1.64Å AUTH J.MARTINEZ,L.D.NGUYEN,E.TAUBERGER,S.HINDERLICH,W.REUTTER,AUTH 2 H.FAN,W.SAENGER,S.MONIOTTITL CRYSTAL STRUCTURES OF N-ACETYLMANNOSAMINE KINASE PROVIDETITL 2 INSIGHTS INTO ENZYME SPECIFICITY AND INHIBITIONREF J.BIOL.CHEM. V. 287 13656 2012REFN ISSN 0021-9258PMID 22343627DOI 10.1074/JBC.M111.318170 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2eb1 DICER1 crystal structure of the c-terminal rnase iii domain of human dicer 2.0Å AUTH D.TAKESHITA,S.ZENNO,W.C.LEE,K.NAGATA,K.SAIGO,M.TANOKURATITL HOMODIMERIC STRUCTURE AND DOUBLE-STRANDED RNA CLEAVAGETITL 2 ACTIVITY OF THE C-TERMINAL RNASE III DOMAIN OF HUMAN DICERREF J.MOL.BIOL. V. 374 106 2007REFN ISSN 0022-2836PMID 17920623DOI 10.1016/J.JMB.2007.08.069 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4ncs NEU2 human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate) 2.2Å AUTH S.BUCHINI,F.X.GALLAT,I.R.GREIG,J.H.KIM,S.WAKATSUKI,AUTH 2 L.M.CHAVAS,S.G.WITHERSTITL TUNING MECHANISM-BASED INACTIVATORS OF NEURAMINIDASES:TITL 2 MECHANISTIC AND STRUCTURAL INSIGHTS.REF ANGEW.CHEM.INT.ED.ENGL. V. 53 3382 2014REFN ISSN 1433-7851PMID 24591206DOI 10.1002/ANIE.201309675 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants