General Structure Information
| PDB ID | 2eb1 |
| HGNC Gene Label(s) | DICER1 |
| Structure Name | crystal structure of the c-terminal rnase iii domain of human dicer |
| Resolution | 2.0Å |
| Reference | AUTH D.TAKESHITA,S.ZENNO,W.C.LEE,K.NAGATA,K.SAIGO,M.TANOKURATITL HOMODIMERIC STRUCTURE AND DOUBLE-STRANDED RNA CLEAVAGETITL 2 ACTIVITY OF THE C-TERMINAL RNASE III DOMAIN OF HUMAN DICERREF J.MOL.BIOL. V. 374 106 2007REFN ISSN 0022-2836PMID 17920623DOI 10.1016/J.JMB.2007.08.069 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 169 |
| Number Of SNVs | 13 |
| Number Of Permutations | 1552 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.218 |
| p-value | 0.625 |
COSMIC
| Number Of Residues | 169 |
| Number Of SNVs | 9 |
| Number Of Permutations | 800 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.111 |
| p-value | 0.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 13 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.346 |
| p-value | 0.141 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
