General Structure Information
| PDB ID | 4ael |
| HGNC Gene Label(s) | PDE10A |
| Structure Name | pde10a in complex with the inhibitor az5 |
| Resolution | 2.2Å |
| Reference | AUTH U.BAUER,F.GIORDANETTO,M.BAUER,G.OMAHONY,K.E.JOHANSSON,AUTH 2 W.KNECHT,J.HARTLEIB-GESCHWINDNER,E.T.CARLSSON,C.ENROTHTITL DISCOVERY OF 4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILETITL 2 DERIVATIVES AS NOVEL PDE10A INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 22 1944 2012REFN ISSN 0960-894XPMID 22321214DOI 10.1016/J.BMCL.2012.01.046 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 321 |
| Number Of SNVs | 44 |
| Number Of Permutations | 21310 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.044 |
| p-value | 0.337 |
COSMIC
| Number Of Residues | 321 |
| Number Of SNVs | 11 |
| Number Of Permutations | 1574 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.4 |
| p-value | 0.101 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 44 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.06 |
| p-value | 0.172 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
