Assessment of Structural Intolerance and Durability
General Structure Information 3tug ITCH crystal structure of the hect domain of itch e3 ubiquitin ligase 2.27Å AUTH E.DOBROVETSKY,A.DONG,S.XUE,C.BUTLER,A.WERNIMONT,J.R.WALKER,AUTH 2 W.TEMPEL,S.DHE-PAGANON,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,AUTH 3 Y.TONGTITL CRYSTAL STRUCTURE OF THE HECT DOMAIN OF ITCH E3 UBIQUITINTITL 2 LIGASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qp3 TTN crystal structure of titin domain m4, tetragonal form 2.0Å AUTH F.SAUER,A.KOLODZIEJCZYK,M.WILMANNSTITL CRYSTAL STRUCTURE OF TITIN DOMAIN M4, TETRAGONAL FORMREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3aj4 PLEKHB2 crystal structure of the ph domain of evectin-2 from human complexed with o-phospho-l-serine 1.0Å AUTH Y.UCHIDA,J.HASEGAWA,D.CHINNAPEN,T.INOUE,S.OKAZAKI,R.KATO,AUTH 2 S.WAKATSUKI,R.MISAKI,M.KOIKE,Y.UCHIYAMA,S.IEMURA,T.NATSUME,AUTH 3 R.KUWAHARA,T.NAKAGAWA,K.NISHIKAWA,K.MUKAI,E.MIYOSHI,AUTH 4 N.TANIGUCHI,D.SHEFF,W.I.LENCER,T.TAGUCHI,H.ARAITITL INTRACELLULAR PHOSPHATIDYLSERINE IS ESSENTIAL FOR RETROGRADETITL 2 MEMBRANE TRAFFIC THROUGH ENDOSOMESREF PROC.NATL.ACAD.SCI.USA V. 108 15846 2011REFN ISSN 0027-8424PMID 21911378DOI 10.1073/PNAS.1109101108 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3siu PRPF31 structure of a hprp31-15.5k-u4atac 5 stem loop complex, monomeric form 2.63Å AUTH S.LIU,H.GHALEI,R.LUHRMANN,M.C.WAHLTITL STRUCTURAL BASIS FOR THE DUAL U4 AND U4ATAC SNRNA-BINDINGTITL 2 SPECIFICITY OF SPLICEOSOMAL PROTEIN HPRP31.REF RNA V. 17 1655 2011REFN ISSN 1355-8382PMID 21784869DOI 10.1261/RNA.2690611 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f8v TTN structure of full length telethonin in complex with the n-terminus of titin 2.75Å AUTH N.PINOTSIS,M.PETOUKHOV,S.LANGE,D.SVERGUN,P.ZOU,M.GAUTEL,AUTH 2 M.WILMANNSTITL EVIDENCE FOR A DIMERIC ASSEMBLY OF TWO TITIN/TELETHONINTITL 2 COMPLEXES INDUCED BY THE TELETHONIN C-TERMINUS.REF J.STRUCT.BIOL. V. 155 239 2006REFN ISSN 1047-8477PMID 16713295DOI 10.1016/J.JSB.2006.03.028 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3zkj ASB9 crystal structure of ankyrin repeat and socs box-containing protein 9 (asb9) in complex with elonginb and elonginc 2.58Å AUTH J.R.C.MUNIZ,K.GUO,N.J.KERSHAW,V.AYINAMPUDI,F.VON DELFT,AUTH 2 J.J.BABON,A.N.BULLOCKTITL MOLECULAR ARCHITECTURE OF THE ANKYRIN SOCS BOX FAMILY OFTITL 2 CUL5-DEPENDENT E3 UBIQUITIN LIGASESREF J.MOL.BIOL. V. 425 3166 2013REFN ISSN 0022-2836PMID 23806657DOI 10.1016/J.JMB.2013.06.015 Variant Set Distributions Ripley’s […]
General Structure Information 4jgh CUL5 structure of the socs2-elongin bc complex bound to an n-terminal fragment of cullin5 3.0Å AUTH Y.K.KIM,M.J.KWAK,B.KU,H.Y.SUH,K.JOO,J.LEE,J.U.JUNG,B.H.OHTITL STRUCTURAL BASIS OF INTERSUBUNIT RECOGNITION IN ELONGINTITL 2 BC-CULLIN 5-SOCS BOX UBIQUITIN-PROTEIN LIGASE COMPLEXES.REF ACTA CRYSTALLOGR.,SECT.D V. 69 1587 2013REFN ISSN 0907-4449PMID 23897481DOI 10.1107/S0907444913011220 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2fv2 RQCD1 crystal structure analysis of human rcd-1 conserved region 2.2Å AUTH R.G.GARCES,W.GILLON,E.F.PAITITL ATOMIC MODEL OF HUMAN RCD-1 REVEALS ANTITL 2 ARMADILLO-LIKE-REPEAT PROTEIN WITH IN VITROTITL 3 NUCLEIC ACID BINDING PROPERTIES.REF PROTEIN SCI. V. 16 176 2007REFN ISSN 0961-8368PMID 17189474DOI 10.1110/PS.062600507 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4n4f CREBBP crystal structure of the bromodomain-phd finger module of human transcriptional co-activator cbp in complex with di-acetylated histone 4 peptide (h412ack16ac). 1.83Å AUTH A.N.PLOTNIKOV,S.YANG,T.J.ZHOU,E.RUSINOVA,A.FRASCA,M.M.ZHOUTITL STRUCTURAL INSIGHTS INTO ACETYLATED-HISTONE H4 RECOGNITIONTITL 2 BY THE BROMODOMAIN-PHD FINGER MODULE OF HUMANTITL 3 TRANSCRIPTIONAL COACTIVATOR CBP.REF STRUCTURE V. 22 353 2014REFN ISSN 0969-2126PMID 24361270DOI 10.1016/J.STR.2013.10.021 […]
General Structure Information 2wwm TTN crystal structure of the titin m10-obscurin like 1 ig complex in space group p1 2.3Å AUTH S.PERNIGO,A.FUKUZAWA,M.BERTZ,M.HOLT,M.RIEF,R.A.STEINER,AUTH 2 M.GAUTELTITL STRUCTURAL INSIGHT INTO M-BAND ASSEMBLY AND MECHANICS FROMTITL 2 THE TITIN-OBSCURIN-LIKE-1 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 107 2908 2010REFN ISSN 0027-8424PMID 20133654DOI 10.1073/PNAS.0913736107 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants