General Structure Information
| PDB ID | 3tug |
| HGNC Gene Label(s) | ITCH |
| Structure Name | crystal structure of the hect domain of itch e3 ubiquitin ligase |
| Resolution | 2.27Å |
| Reference | AUTH E.DOBROVETSKY,A.DONG,S.XUE,C.BUTLER,A.WERNIMONT,J.R.WALKER,AUTH 2 W.TEMPEL,S.DHE-PAGANON,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,AUTH 3 Y.TONGTITL CRYSTAL STRUCTURE OF THE HECT DOMAIN OF ITCH E3 UBIQUITINTITL 2 LIGASEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 334 |
| Number Of SNVs | 34 |
| Number Of Permutations | 6450 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.094 |
| p-value | 0.344 |
COSMIC
| Number Of Residues | 334 |
| Number Of SNVs | 3 |
| Number Of Permutations | 18 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.667 |
| p-value | 0.272 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.681 |
| p-value | 0.273 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
