Assessment of Structural Intolerance and Durability
General Structure Information 4fgu LGMN crystal structure of prolegumain 3.9Å AUTH E.DALL,H.BRANDSTETTERTITL MECHANISTIC AND STRUCTURAL STUDIES ON LEGUMAIN EXPLAIN ITSTITL 2 ZYMOGENICITY, DISTINCT ACTIVATION PATHWAYS, AND REGULATION.REF PROC.NATL.ACAD.SCI.USA V. 110 10940 2013REFN ISSN 0027-8424PMID 23776206DOI 10.1073/PNAS.1300686110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f6k SORT1 crystal structure of the vps10p domain of human sortilin/nts3 in complex with neurotensin 2.0Å AUTH E.M.QUISTGAARD,P.MADSEN,M.K.GROFTEHAUGE,P.NISSEN,AUTH 2 C.M.PETERSEN,S.S.THIRUPTITL LIGANDS BIND TO SORTILIN IN THE TUNNEL OF A TEN-BLADEDTITL 2 BETA-PROPELLER DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 16 96 2009REFN ISSN 1545-9993PMID 19122660DOI 10.1038/NSMB.1543 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1nd7 WWP1 conformational flexibility underlies ubiquitin ligation mediated by the wwp1 hect domain e3 ligase 2.1Å AUTH M.A.VERDECIA,C.A.P.JOAZIERO,N.J.WELLS,J.-L.FERRER,AUTH 2 M.E.BOWMAN,T.HUNTER,J.P.NOELTITL CONFORMATIONAL FLEXIBILITY UNDERLIES UBIQUITINTITL 2 LIGATION MEDIATED BY THE WWP1 HECT DOMAIN E3 LIGASEREF MOL.CELL V. 11 249 2003REFN ISSN 1097-2765PMID 12535537DOI 10.1016/S1097-2765(02)00774-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2jrf TPPP3 solution nmr structure of tubulin polymerization-promoting protein family member 3 from homo sapiens. northeast structural genomics target hr387. -1.0Å AUTH J.M.ARAMINI,P.ROSSI,R.SHASTRY,C.NWOSU,K.CUNNINGHAM,AUTH 2 R.XIAO,J.LIU,M.C.BARAN,P.K.RAJAN,T.B.ACTON,B.ROST,AUTH 3 G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF TUBULINTITL 2 POLYMERIZATION-PROMOTING PROTEIN FAMILY MEMBER 3TITL 3 FROM HOMO SAPIENS.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2okj GAD1 the x-ray crystal structure of the 67kda isoform of glutamic acid decarboxylase (gad67) 2.3Å AUTH G.FENALTI,R.H.P.LAW,A.M.BUCKLE,C.LANGENDORF,K.TUCK,AUTH 2 C.J.ROSADO,N.G.FAUX,K.MAHMOOD,C.S.HAMPE,J.P.BANGA,AUTH 3 M.WILCE,J.SCHMIDBERGER,J.ROSSJOHN,O.EL-KABBANI,AUTH 4 R.N.PIKE,A.I.SMITH,I.R.MACKAY,M.J.ROWLEY,AUTH 5 J.C.WHISSTOCKTITL GABA PRODUCTION BY GLUTAMIC ACID DECARBOXYLASE ISTITL 2 REGULATED BY A DYNAMIC CATALYTIC LOOP.REF NAT.STRUCT.MOL.BIOL. V. 14 280 2007REFN ISSN 1545-9993PMID 17384644DOI 10.1038/NSMB1228 Variant Set Distributions […]
General Structure Information 2cn1 NT5C3A crystal structure of human cytosolic 5-nucleotidase iii ( nt5c3)(casp target) 2.67Å AUTH K.WALLDEN,P.STENMARK,T.NYMAN,S.FLODIN,S.GRASLUND,P.LOPPNAU,AUTH 2 V.BIANCHI,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5-NUCLEOTIDASE II:TITL 2 INSIGHTS INTO ALLOSTERIC REGULATION AND SUBSTRATETITL 3 RECOGNITION.REF J.BIOL.CHEM. V. 282 17828 2007REFN ISSN 0021-9258PMID 17405878DOI 10.1074/JBC.M700917200 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4im6 NLRP1 lrr domain from human nlrp1 1.65Å Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rep KIFC1 crystal structure of the motor domain of human kinesin family member c1 2.6Å AUTH H.ZHU,W.TEMPEL,H.HE,Y.SHEN,J.WANG,G.BROTHERS,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINESINTITL 2 FAMILY MEMBER C1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yud YTHDC1 solution structure of the yth domain in yth domain- containing protein 1 (putative splicing factor yt521) -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TARADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE YTH DOMAIN IN YTHTITL 2 DOMAIN-CONTAINING PROTEIN 1 (PUTATIVE SPLICINGTITL 3 FACTOR YT521)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3d34 SPON2 structure of the f-spondin domain of mindin 1.8Å AUTH Y.LI,C.CAO,W.JIA,L.YU,M.MO,Q.WANG,Y.HUANG,J.M.LIM,AUTH 2 M.ISHIHARA,L.WELLS,P.AZADI,H.ROBINSON,Y.W.HE,AUTH 3 L.ZHANG,R.A.MARIUZZATITL STRUCTURE OF THE F-SPONDIN DOMAIN OF MINDIN, ANTITL 2 INTEGRIN LIGAND AND PATTERN RECOGNITION MOLECULE.REF EMBO J. V. 28 286 2009REFN ISSN 0261-4189PMID 19153605DOI 10.1038/EMBOJ.2008.288 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]