Assessment of Structural Intolerance and Durability
General Structure Information 1xa6 CHN2 crystal structure of the human beta2-chimaerin 3.2Å AUTH B.CANAGARAJAH,F.C.LESKOW,J.Y.HO,H.MISCHAK,AUTH 2 L.F.SAIDI,M.G.KAZANIETZ,J.H.HURLEYTITL STRUCTURAL MECHANISM FOR LIPID ACTIVATION OF THETITL 2 RAC-SPECIFIC GAP, BETA2-CHIMAERIN.REF CELL(CAMBRIDGE,MASS.) V. 119 407 2004REFN ISSN 0092-8674PMID 15507211DOI 10.1016/J.CELL.2004.10.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ger PYCR1 crystal structure and oxidative mechanism of human pyrroline-5- carboxylate reductase 3.1Å AUTH Z.MENG,Z.LOU,Z.LIU,M.LI,X.ZHAO,M.BARTLAM,Z.RAOTITL CRYSTAL STRUCTURE OF HUMAN PYRROLINE-5-CARBOXYLATE REDUCTASEREF J.MOL.BIOL. V. 359 1364 2006REFN ISSN 0022-2836PMID 16730026DOI 10.1016/J.JMB.2006.04.053 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bkt VHL von hippel lindau protein:elonginb:elonginc complex, in complex with (2s,4r)-n-methyl-1-[2-(3-methyl-1,2-oxazol-5-yl)ethanoyl]-4- oxidanyl-pyrrolidine-2-carboxamide 2.35Å AUTH D.M.DIAS,I.VAN MOLLE,M.G.J.BAUD,C.GALDEANO,C.F.G.C.GERALDES,AUTH 2 A.CIULLITITL IS NMR FRAGMENT SCREENING FINE-TUNED TO ASSESS DRUGGABILITYTITL 2 OF PROTEIN-PROTEIN INTERACTIONS?REF ACS MED.CHEM.LETT. V. 5 23 2014REFN ISSN 1948-5875PMID 24436777DOI 10.1021/ML400296C Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3wef FDFT1 crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate 2.35Å AUTH C.I.LIU,W.Y.JENG,W.J.CHANG,M.F.SHIH,T.P.KO,A.H.J.WANGTITL STRUCTURAL INSIGHTS INTO THE CATALYTIC MECHANISM OF HUMANTITL 2 SQUALENE SYNTHASEREF ACTA CRYSTALLOGR.,SECT.D V. 70 231 2014REFN ISSN 0907-4449DOI 10.1107/S1399004713026230 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4k5y CRHR1 crystal structure of human corticotropin-releasing factor receptor 1 (crf1r) in complex with the antagonist cp-376395 2.98Å AUTH K.HOLLENSTEIN,J.KEAN,A.BORTOLATO,R.K.CHENG,A.S.DORE,AUTH 2 A.JAZAYERI,R.M.COOKE,M.WEIR,F.H.MARSHALLTITL STRUCTURE OF CLASS B GPCR CORTICOTROPIN-RELEASING FACTORTITL 2 RECEPTOR 1.REF NATURE V. 499 438 2013REFN ISSN 0028-0836PMID 23863939DOI 10.1038/NATURE12357 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4ip7 PKLR structure of the s12d variant of human liver pyruvate kinase in complex with citrate and fbp. 1.8Å AUTH T.HOLYOAK,B.ZHANG,J.DENG,Q.TANG,C.B.PRASANNAN,A.W.FENTONTITL ENERGETIC COUPLING BETWEEN AN OXIDIZABLE CYSTEINE AND THETITL 2 PHOSPHORYLATABLE N-TERMINUS OF HUMAN LIVER PYRUVATE KINASE.REF BIOCHEMISTRY V. 52 466 2013REFN ISSN 0006-2960PMID 23270483DOI 10.1021/BI301341R Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2lul TEC solution nmr structure of ph domain of tyrosine-protein kinase tec from homo sapiens, northeast structural genomics consortium (nesg) target hr3504c -1.0Å AUTH G.LIU,R.XIAO,H.JANJUA,K.HAMILTON,R.SHASTRY,E.KOHAN,AUTH 2 T.B.ACTON,J.K.EVERETT,H.LEE,K.PEDERSON,Y.J.HUANG,AUTH 3 G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF PH DOMAIN OF TYROSINE-PROTEINTITL 2 KINASE TEC FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICSTITL 3 CONSORTIUM (NESG) TARGET HR3504CREF TO […]
General Structure Information 3dwb ECE1 structure of human ece-1 complexed with phosphoramidon 2.38Å AUTH H.SCHULZ,G.E.DALE,Y.KARIMI-NEJAD,C.OEFNERTITL STRUCTURE OF HUMAN ENDOTHELIN-CONVERTING ENZYME I COMPLEXEDTITL 2 WITH PHOSPHORAMIDONREF J.MOL.BIOL. V. 385 178 2009REFN ISSN 0022-2836PMID 18992253DOI 10.1016/J.JMB.2008.10.052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zt7 GARS crystal structure of human glycyl-trna synthetase (glyrs) in complex with glycine and atp 2.7Å AUTH R.T.GUO,Y.E.CHONG,M.GUO,X.L.YANGTITL CRYSTAL STRUCTURES AND BIOCHEMICAL ANALYSES SUGGESTTITL 2 UNIQUE MECHANISM AND ROLE FOR HUMAN GLYRS IN AP4ATITL 3 HOMEOSTASISREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3ua8 GRIA2 crystal structure analysis of a 6-amino quinazolinedione sulfonamide bound to human glur2 1.9Å AUTH D.ORAIN,S.OFNER,M.KOLLER,D.A.CARCACHE,W.FROESTL,H.ALLGEIER,AUTH 2 V.RASETTI,J.NOZULAK,H.MATTES,N.SOLDERMANN,P.FLOERSHEIM,AUTH 3 S.DESRAYAUD,J.KALLEN,K.LINGENHOEHL,S.URWYLERTITL 6-AMINO QUINAZOLINEDIONE SULFONAMIDES AS ORALLY ACTIVETITL 2 COMPETITIVE AMPA RECEPTOR ANTAGONISTS.REF BIOORG.MED.CHEM.LETT. V. 22 996 2012REFN ISSN 0960-894XPMID 22197388DOI 10.1016/J.BMCL.2011.12.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]