3ETO.B | NOTCH1

General Structure Information 3eto NOTCH1 2 angstrom xray structure of the notch1 negative regulatory region (nrr) 2.0Å AUTH W.R.GORDON,M.ROY,D.VARDAR-ULU,M.GARFINKEL,M.R.MANSOUR,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURE OF THE NOTCH1-NEGATIVE REGULATORY REGION:TITL 2 IMPLICATIONS FOR NORMAL ACTIVATION AND PATHOGENIC SIGNALINGTITL 3 IN T-ALL.REF BLOOD V. 113 4381 2009REFN ISSN 0006-4971PMID 19075186DOI 10.1182/BLOOD-2008-08-174748 Variant Set Distributions Ripley’s K Analysis Plots Variant […]

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4KKD.A | MASP1

General Structure Information 4kkd MASP1 the x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the 3mc syndrome 2.6Å AUTH T.YONGQING,P.G.WILMANN,S.B.REEVE,T.H.COETZER,A.I.SMITH,AUTH 2 J.C.WHISSTOCK,R.N.PIKE,L.C.WIJEYEWICKREMATITL THE X-RAY CRYSTAL STRUCTURE OF MANNOSE-BINDINGTITL 2 LECTIN-ASSOCIATED SERINE PROTEINASE-3 REVEALS THE STRUCTURALTITL 3 BASIS FOR ENZYME INACTIVITY ASSOCIATED WITH THE CARNEVALE,TITL 4 MINGARELLI, […]

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2HGM.A | HNRNPF

General Structure Information 2hgm HNRNPF nmr structure of the second qrrm domain of human hnrnp f -1.0Å AUTH C.DOMINGUEZ,F.H.ALLAINTITL NMR STRUCTURE OF THE THREE QUASI RNA RECOGNITIONTITL 2 MOTIFS (QRRMS) OF HUMAN HNRNP F AND INTERACTIONTITL 3 STUDIES WITH BCL-X G-TRACT RNA: A NOVEL MODE OFTITL 4 RNA RECOGNITION.REF NUCLEIC ACIDS RES. V. 34 3634 […]

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2WYA.C | HMGCS2

General Structure Information 2wya HMGCS2 crystal structure of human mitochondrial 3-hydroxy-3- methylglutaryl-coenzyme a synthase 2 (hmgcs2) 1.7Å AUTH N.SHAFQAT,A.TURNBULL,J.ZSCHOCKE,U.OPPERMANN,AUTH 2 W.W.YUETITL CRYSTAL STRUCTURES OF HUMAN HMG-COA SYNTHASETITL 2 ISOFORMS PROVIDE INSIGHTS INTO INHERITEDTITL 3 KETOGENESIS DISORDERS AND INHIBITOR DESIGN.REF J.MOL.BIOL. V. 398 497 2010REFN ISSN 0022-2836PMID 20346956DOI 10.1016/J.JMB.2010.03.034 Variant Set Distributions Ripley’s K Analysis Plots […]

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2COJ.B | BCAT1

General Structure Information 2coj BCAT1 crystal structure of reduced human cytosolic branched-chain aminotransferase complexed with gabapentin 2.4Å AUTH M.GOTO,I.MIYAHARA,K.HIROTSU,M.CONWAY,N.YENNAWAR,M.M.ISLAM,AUTH 2 S.M.HUTSONTITL STRUCTURAL DETERMINANTS FOR BRANCHED-CHAIN AMINOTRANSFERASETITL 2 ISOZYME-SPECIFIC INHIBITION BY THE ANTICONVULSANT DRUGTITL 3 GABAPENTINREF J.BIOL.CHEM. V. 280 37246 2005REFN ISSN 0021-9258PMID 16141215DOI 10.1074/JBC.M506486200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]

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3T1I.C | MRE11A

General Structure Information 3t1i MRE11A crystal structure of human mre11: understanding tumorigenic mutations 3.0Å AUTH Y.B.PARK,J.CHAE,Y.KIM,Y.CHOTITL CRYSTAL STRUCTURE OF HUMAN MRE11: UNDERSTANDING TUMORIGENICTITL 2 MUTATIONSREF STRUCTURE V. 19 1591 2011REFN ISSN 0969-2126PMID 22078559DOI 10.1016/J.STR.2011.09.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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4KBC.A | CSNK1D

General Structure Information 4kbc CSNK1D ck1d in complex with {4-[3-(4-fluorophenyl)-1h-pyrazol-4-yl]pyridin-2- yl}methanol inhibitor 1.98Å AUTH S.MENTE,E.ARNOLD,T.BUTLER,S.CHAKRAPANI,R.CHANDRASEKARAN,AUTH 2 K.CHERRY,K.DIRICO,A.DORAN,K.FISHER,P.GALATSIS,M.GREEN,AUTH 3 M.HAYWARD,J.HUMPHREY,J.KNAFELS,J.LI,S.LIU,M.MARCONI,AUTH 4 S.MCDONALD,J.OHREN,V.PARADIS,B.SNEED,K.WALTON,T.WAGERTITL LIGAND-PROTEIN INTERACTIONS OF SELECTIVE CASEIN KINASE 1TITL 2 DELTA INHIBITORS.REF J.MED.CHEM. V. 56 6819 2013REFN ISSN 0022-2623PMID 23919824DOI 10.1021/JM4006324 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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2AOT.B | HNMT

General Structure Information 2aot HNMT histamine methyltransferase complexed with the antihistamine drug diphenhydramine 1.9Å AUTH J.R.HORTON,K.SAWADA,M.NISHIBORI,X.CHENGTITL STRUCTURAL BASIS FOR INHIBITION OF HISTAMINETITL 2 N-METHYLTRANSFERASE BY DIVERSE DRUGSREF J.MOL.BIOL. V. 353 334 2005REFN ISSN 0022-2836PMID 16168438DOI 10.1016/J.JMB.2005.08.040 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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1NST.A | NDST1

General Structure Information 1nst NDST1 the sulfotransferase domain of human haparin sulfate n- deacetylase/n-sulfotransferase 2.3Å AUTH Y.KAKUTA,T.SUEYOSHI,M.NEGISHI,L.C.PEDERSENTITL CRYSTAL STRUCTURE OF THE SULFOTRANSFERASE DOMAINTITL 2 OF HUMAN HEPARAN SULFATE N-DEACETYLASE/TITL 3 N-SULFOTRANSFERASE 1.REF J.BIOL.CHEM. V. 274 10673 1999REFN ISSN 0021-9258PMID 10196134DOI 10.1074/JBC.274.16.10673 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]

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4JA8.B | IDH2

General Structure Information 4ja8 IDH2 complex of mitochondrial isocitrate dehydrogenase r140q mutant with agi-6780 inhibitor 1.55Å AUTH F.WANG,J.TRAVINS,B.DELABARRE,V.PENARD-LACRONIQUE,S.SCHALM,AUTH 2 E.HANSEN,K.STRALEY,A.KERNYTSKY,W.LIU,C.GLISER,H.YANG,AUTH 3 S.GROSS,E.ARTIN,V.SAADA,E.MYLONAS,C.QUIVORON,AUTH 4 J.POPOVICI-MULLER,J.O.SAUNDERS,F.G.SALITURO,S.YAN,S.MURRAY,AUTH 5 W.WEI,Y.GAO,L.DANG,M.DORSCH,S.AGRESTA,D.P.SCHENKEIN,AUTH 6 S.A.BILLER,S.M.SU,S.DE BOTTON,K.E.YENTITL TARGETED INHIBITION OF MUTANT IDH2 IN LEUKEMIA CELLS INDUCESTITL 2 CELLULAR DIFFERENTIATION.REF SCIENCE V. 340 622 2013REFN ISSN 0036-8075PMID 23558173DOI 10.1126/SCIENCE.1234769 Variant Set Distributions Ripley’s K […]

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