Assessment of Structural Intolerance and Durability
General Structure Information 1k93 CALM2 crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin 2.95Å AUTH C.L.DRUM,S.-Z.YAN,J.BARD,Y.-Q.SHEN,D.LU,AUTH 2 S.SOELAIMAN,Z.GRABAREK,A.BOHM,W.-J.TANGTITL STRUCTURAL BASIS FOR THE ACTIVATION OF ANTHRAXTITL 2 ADENYLYL CYCLASE EXOTOXIN BY CALMODULIN.REF NATURE V. 415 396 2002REFN ISSN 0028-0836PMID 11807546DOI 10.1038/415396A Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1k93 CALM1 crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin 2.95Å AUTH C.L.DRUM,S.-Z.YAN,J.BARD,Y.-Q.SHEN,D.LU,AUTH 2 S.SOELAIMAN,Z.GRABAREK,A.BOHM,W.-J.TANGTITL STRUCTURAL BASIS FOR THE ACTIVATION OF ANTHRAXTITL 2 ADENYLYL CYCLASE EXOTOXIN BY CALMODULIN.REF NATURE V. 415 396 2002REFN ISSN 0028-0836PMID 11807546DOI 10.1038/415396A Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1a3q NFKB2 human nf-kappa-b p52 bound to dna 2.1Å AUTH P.CRAMER,C.J.LARSON,G.L.VERDINE,C.W.MULLERTITL STRUCTURE OF THE HUMAN NF-KAPPAB P52 HOMODIMER-DNATITL 2 COMPLEX AT 2.1 A RESOLUTION.REF EMBO J. V. 16 7078 1997REFN ISSN 0261-4189PMID 9384586DOI 10.1093/EMBOJ/16.23.7078 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4my2 NDP crystal structure of norrin in fusion with maltose binding protein 2.4Å AUTH J.KE,K.G.HARIKUMAR,C.ERICE,C.CHEN,X.GU,L.WANG,N.PARKER,AUTH 2 Z.CHENG,W.XU,B.O.WILLIAMS,K.MELCHER,L.J.MILLER,H.E.XUTITL STRUCTURE AND FUNCTION OF NORRIN IN ASSEMBLY AND ACTIVATIONTITL 2 OF A FRIZZLED 4-LRP5/6 COMPLEX.REF GENES DEV. V. 27 2305 2013REFN ISSN 0890-9369PMID 24186977DOI 10.1101/GAD.228544.113 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l6a NLRP12 three-dimensional structure of the n-terminal effector pyrin domain of nlrp12 -1.0Å AUTH A.S.PINHEIRO,C.EIBL,Z.EKMAN-VURAL,R.SCHWARZENBACHER,W.PETITITL THE NLRP12 PYRIN DOMAIN: STRUCTURE, DYNAMICS, AND FUNCTIONALTITL 2 INSIGHTS.REF J.MOL.BIOL. V. 413 790 2011REFN ISSN 0022-2836PMID 21978668DOI 10.1016/J.JMB.2011.09.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1uw5 PITPNA structure of pitp-alpha complexed to phosphatidylinositol 2.9Å AUTH S.J.TILLEY,A.SKIPPEN,J.MURRAY-RUST,P.M.SWIGART,AUTH 2 A.STEWART,C.P.MORGAN,S.COCKCROFT,N.Q.MCDONALDTITL STRUCTURE-FUNCTION ANALYSIS OF HUMAN [CORRECTED]TITL 2 PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA BOUNDTITL 3 TO PHOSPHATIDYLINOSITOL.REF STRUCTURE V. 12 317 2004REFN ISSN 0969-2126PMID 14962392DOI 10.1016/J.STR.2004.01.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3tso RAB25 structure of the cancer associated rab25 protein in complex with fip2 1.8Å AUTH S.ODA,P.Y.LALL,M.W.MCCAFFREY,A.R.KHANTITL STRUCTURE OF THE CANCER ASSOCIATED RAB25 PROTEIN IN COMPLEXTITL 2 WITH FIP2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bg0 SEC13 architecture of a coat for the nuclear pore membrane 3.15Å AUTH K.C.HSIA,P.STAVROPOULOS,G.BLOBEL,A.HOELZTITL ARCHITECTURE OF A COAT FOR THE NUCLEAR PORETITL 2 MEMBRANE.REF CELL(CAMBRIDGE,MASS.) V. 131 1313 2007REFN ISSN 0092-8674PMID 18160040DOI 10.1016/J.CELL.2007.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4iyp IGBP1 structure of the npp2ac-alpha4 complex 2.8Å AUTH L.JIANG,V.STANEVICH,K.A.SATYSHUR,M.KONG,G.R.WATKINS,AUTH 2 B.E.WADZINSKI,R.SENGUPTA,Y.XINGTITL STRUCTURAL BASIS OF PROTEIN PHOSPHATASE 2A STABLE LATENCY.REF NAT COMMUN V. 4 1699 2013REFN ESSN 2041-1723PMID 23591866DOI 10.1038/NCOMMS2663 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3d9s AQP5 human aquaporin 5 (aqp5) – high resolution x-ray structure 2.0Å AUTH R.HORSEFIELD,K.NORDEN,M.FELLERT,A.BACKMARK,AUTH 2 S.TORNROTH-HORSEFIELD,AUTH 3 A.C.TERWISSCHA VAN SCHELTINGA,J.KVASSMAN,AUTH 4 P.KJELLBOM,U.JOHANSON,R.NEUTZETITL HIGH-RESOLUTION X-RAY STRUCTURE OF HUMAN AQUAPORINTITL 2 5REF PROC.NATL.ACAD.SCI.USA V. 105 13327 2008REFN ISSN 0027-8424PMID 18768791DOI 10.1073/PNAS.0801466105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]