General Structure Information
| PDB ID | 1k93 |
| HGNC Gene Label(s) | CALM2 |
| Structure Name | crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin |
| Resolution | 2.95Å |
| Reference | AUTH C.L.DRUM,S.-Z.YAN,J.BARD,Y.-Q.SHEN,D.LU,AUTH 2 S.SOELAIMAN,Z.GRABAREK,A.BOHM,W.-J.TANGTITL STRUCTURAL BASIS FOR THE ACTIVATION OF ANTHRAXTITL 2 ADENYLYL CYCLASE EXOTOXIN BY CALMODULIN.REF NATURE V. 415 396 2002REFN ISSN 0028-0836PMID 11807546DOI 10.1038/415396A |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 143 |
| Number Of SNVs | 16 |
| Number Of Permutations | 8547 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.242 |
| p-value | 0.697 |
ClinVar
| Number Of Residues | 143 |
| Number Of SNVs | 8 |
| Number Of Permutations | 4190 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.179 |
| p-value | 0.003 |
COSMIC
| Number Of Residues | 143 |
| Number Of SNVs | 3 |
| Number Of Permutations | 109 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 16 |
| Number Of ClinVar SNVs | 8 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.227 |
| p-value | 0.002 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 16 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | -0.258 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
