Assessment of Structural Intolerance and Durability
General Structure Information 1yb5 CRYZ crystal structure of human zeta-crystallin with bound nadp 1.85Å AUTH J.DEBRECZENI,G.BERRIDGE,K.KAVANAGH,S.COLBROOK,J.BRAY,AUTH 2 L.WILLIAMS,U.OPPERMANN,M.SUNDSTROM,C.ARROWSMITH,A.EDWARDS,AUTH 3 O.GILEADI,F.VON DELFTTITL CRYSTAL STRUCTURE OF HUMAN ZETA-CRYSTALLIN AT 1.85AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rii PRDX1 crystal structure of human peroxiredoxin i in complex with sulfiredoxin 2.6Å AUTH T.J.JONSSON,L.C.JOHNSON,W.T.LOWTHERTITL STRUCTURE OF THE SULPHIREDOXIN-PEROXIREDOXIN COMPLEX REVEALSTITL 2 AN ESSENTIAL REPAIR EMBRACE.REF NATURE V. 451 98 2008REFN ISSN 0028-0836PMID 18172504DOI 10.1038/NATURE06415 Variant Set Distributions Mapped Variants
General Structure Information 1zsx KCNAB2 crystal structure of human potassium channel kv beta-subunit (kcnab2) 1.9Å AUTH P.WENNERSTRAND,I.JOHANNSSON,E.UGOCHUKWU,K.KAVANAGH,AUTH 2 A.EDWARDS,C.ARROWSMITH,L.WILLIAMS,M.SUNDSTROM,K.GUO,AUTH 3 F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN POTASSIUM CHANNEL KV BETA-SUBUNITTITL 2 (KCNAB2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1pl6 SORD human sdh/nadh/inhibitor complex 2.0Å AUTH T.A.PAULY,J.L.EKSTROM,D.A.BEEBE,B.CHRUNYK,D.CUNNINGHAM,AUTH 2 M.GRIFFOR,A.KAMATH,S.E.LEE,R.MADURA,D.MCGUIRE,T.SUBASHI,AUTH 3 D.WASILKO,P.WATTS,B.L.MYLARI,P.J.OATES,P.D.ADAMS,V.L.RATHTITL X-RAY CRYSTALLOGRAPHIC AND KINETIC STUDIES OF HUMAN SORBITOLTITL 2 DEHYDROGENASE.REF STRUCTURE V. 11 1071 2003REFN ISSN 0969-2126PMID 12962626DOI 10.1016/S0969-2126(03)00167-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3tkr PRDX4 crystal structure of full-length human peroxiredoxin 4 with t118e mutation 2.1Å AUTH X.WANG,L.WANG,X.WANG,F.SUN,C.-C.WANGTITL STRUCTURAL INSIGHTS INTO THE PEROXIDASE ACTIVITY ANDTITL 2 INACTIVATION OF HUMAN PEROXIREDOXIN 4REF BIOCHEM.J. 2011REFN ESSN 1470-8728PMID 21916849DOI 10.1042/BJ20110380 Variant Set Distributions Mapped Variants
General Structure Information 1yb5 CRYZ crystal structure of human zeta-crystallin with bound nadp 1.85Å AUTH J.DEBRECZENI,G.BERRIDGE,K.KAVANAGH,S.COLBROOK,J.BRAY,AUTH 2 L.WILLIAMS,U.OPPERMANN,M.SUNDSTROM,C.ARROWSMITH,A.EDWARDS,AUTH 3 O.GILEADI,F.VON DELFTTITL CRYSTAL STRUCTURE OF HUMAN ZETA-CRYSTALLIN AT 1.85AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rii PRDX1 crystal structure of human peroxiredoxin i in complex with sulfiredoxin 2.6Å AUTH T.J.JONSSON,L.C.JOHNSON,W.T.LOWTHERTITL STRUCTURE OF THE SULPHIREDOXIN-PEROXIREDOXIN COMPLEX REVEALSTITL 2 AN ESSENTIAL REPAIR EMBRACE.REF NATURE V. 451 98 2008REFN ISSN 0028-0836PMID 18172504DOI 10.1038/NATURE06415 Variant Set Distributions Mapped Variants
General Structure Information 1zsx KCNAB2 crystal structure of human potassium channel kv beta-subunit (kcnab2) 1.9Å AUTH P.WENNERSTRAND,I.JOHANNSSON,E.UGOCHUKWU,K.KAVANAGH,AUTH 2 A.EDWARDS,C.ARROWSMITH,L.WILLIAMS,M.SUNDSTROM,K.GUO,AUTH 3 F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN POTASSIUM CHANNEL KV BETA-SUBUNITTITL 2 (KCNAB2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1pl6 SORD human sdh/nadh/inhibitor complex 2.0Å AUTH T.A.PAULY,J.L.EKSTROM,D.A.BEEBE,B.CHRUNYK,D.CUNNINGHAM,AUTH 2 M.GRIFFOR,A.KAMATH,S.E.LEE,R.MADURA,D.MCGUIRE,T.SUBASHI,AUTH 3 D.WASILKO,P.WATTS,B.L.MYLARI,P.J.OATES,P.D.ADAMS,V.L.RATHTITL X-RAY CRYSTALLOGRAPHIC AND KINETIC STUDIES OF HUMAN SORBITOLTITL 2 DEHYDROGENASE.REF STRUCTURE V. 11 1071 2003REFN ISSN 0969-2126PMID 12962626DOI 10.1016/S0969-2126(03)00167-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2h63 BLVRA crystal structure of human biliverdin reductase a (casp target) 2.7Å AUTH K.KAVANAGH,J.ELKINS,E.UGOCHUKWU,K.GUO,E.PILKA,AUTH 2 P.LUKACIK,C.SMEE,E.PAPAGRIGORIOU,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BILIVERDIN REDUCTASE AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants