General Structure Information
| PDB ID | 2h63 |
| HGNC Gene Label(s) | BLVRA |
| Structure Name | crystal structure of human biliverdin reductase a (casp target) |
| Resolution | 2.7Å |
| Reference | AUTH K.KAVANAGH,J.ELKINS,E.UGOCHUKWU,K.GUO,E.PILKA,AUTH 2 P.LUKACIK,C.SMEE,E.PAPAGRIGORIOU,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BILIVERDIN REDUCTASE AREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 284 |
| Number Of SNVs | 75 |
| Number Of Permutations | 31382 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.039 |
| p-value | 0.618 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 7:43827515 | COSM3663202 | F>L | D:9 | (-42.17, -6.14, -48.32) |
| 7:43827521 | rs201359042 | V>M | D:11 | (-38.92, -10.46, -53.64) |
| 7:43827543 | R>Q | D:18 | (-22.39, -16.33, -57.44) | |
| 7:43827548 | rs138715080 | G>S | D:20 | (-28.31, -14.84, -56.33) |
| 7:43827554 | V>M | D:22 | (-26.61, -16.14, -51.60) | |
| 7:43827557 | COSM746843 | R>W | D:23 | (-29.22, -12.06, -51.65) |
| 7:43827572 | R>G | D:28 | (-35.49, -19.88, -48.76) | |
| 7:43827573 | R>Q | D:28 | (-35.49, -19.88, -48.76) | |
| 7:43827584 | P>S | D:32 | (-34.83, -11.90, -38.88) | |
| 7:43827585 | P>R | D:32 | (-34.83, -11.90, -38.88) | |
| 7:43827594 | A>V | D:35 | (-39.84, -12.45, -42.18) | |
| 7:43827599 | rs17245918 | L>V | D:37 | (-39.02, -10.48, -47.39) |
| 7:43827609 | rs530389071 | I>T | D:40 | (-42.80, -14.15, -55.86) |
| 7:43827621 | rs387906596 COSM188813 CM112102 |
S>W | D:44 | (-33.01, -15.56, -66.25) |
| 7:43830862 | S>T | D:50 | (-37.20, -24.42, -60.89) | |
| 7:43830867 | rs142693095 | D>N | D:52 | (-35.02, -24.28, -54.28) |
| 7:43830870 | G>R | D:53 | (-39.41, -24.10, -55.91) | |
| 7:43830880 | rs1050916 | Q>R | D:56 | (-38.09, -18.68, -64.50) |
| 7:43830898 | A>V | D:62 | (-42.09, -8.73, -63.02) | |
| 7:43830928 | rs138636653 | Y>C | D:72 | (-33.12, -8.60, -54.10) |
| 7:43830937 | S>N | D:75 | (-26.55, -8.67, -62.71) | |
| 7:43830943 | S>N | D:77 | (-22.22, -4.62, -63.54) | |
| 7:43830952 | COSM1193268 | H>R | D:80 | (-26.51, -3.59, -62.32) |
| 7:43830954 | rs531657910 | E>K | D:81 | (-28.05, 1.82, -65.80) |
| 7:43830957 | rs368001334 | D>N | D:82 | (-31.37, -1.68, -67.84) |
| 7:43830967 | R>K | D:85 | (-33.54, 3.26, -65.84) | |
| 7:43832321 | L>F | D:88 | (-37.14, 2.50, -59.99) | |
| 7:43832339 | V>I | D:94 | (-33.97, -1.50, -55.89) | |
| 7:43832343 | L>P | D:95 | (-31.07, -4.82, -53.71) | |
| 7:43832366 | S>P | D:103 | (-21.82, 6.21, -64.24) | |
| 7:43832370 | rs148571710 | L>S | D:104 | (-21.62, 9.86, -61.22) |
| 7:43832373 | rs142897365 | A>V | D:105 | (-24.62, 10.16, -63.98) |
| 7:43832375 | rs143540634 | A>T | D:106 | (-26.44, 7.14, -63.67) |
| 7:43832384 | E>K | D:109 | (-31.09, 9.14, -63.61) | |
| 7:43832408 | K>Q | D:117 | (-41.18, 6.85, -57.76) | |
| 7:43840066 | K>E | D:119 | (-39.80, 3.35, -53.85) | |
| 7:43840078 | E>K | D:123 | (-24.65, 0.13, -53.57) | |
| 7:43840111 | rs149777705 | A>T | D:134 | (-14.49, -4.74, -37.92) |
| 7:43840133 | COSM1184750 | V>A | D:141 | (-10.27, 4.81, -33.67) |
| 7:43840142 | D>V | D:144 | (-2.84, 9.64, -37.45) | |
| 7:43840160 | L>P | D:150 | (-5.08, -1.89, -50.37) | |
| 7:43843287 | E>G | D:158 | (-14.93, -9.34, -67.86) | |
| 7:43843295 | rs377670975 | R>W | D:161 | (-20.06, -9.58, -67.89) |
| 7:43843296 | rs146795036 | R>Q | D:161 | (-20.06, -9.58, -67.89) |
| 7:43843307 | rs144345502 | P>S | D:165 | (-10.93, -2.13, -62.50) |
| 7:43843316 | S>G | D:168 | (-14.71, -4.14, -59.85) | |
| 7:43843322 | I>L | D:170 | (-16.04, 0.18, -55.51) | |
| 7:43843341 | L>P | D:176 | (-9.52, 3.29, -48.29) | |
| 7:43843344 | V>A | D:177 | (-13.56, 6.19, -47.96) | |
| 7:43843349 | L>F | D:179 | (-11.17, 3.48, -42.66) | |
| 7:43843354 | F>L | D:180 | (-8.53, 6.33, -43.82) | |
| 7:43843356 | G>E | D:181 | (-12.41, 9.54, -45.86) | |
| 7:43843367 | rs143532590 | L>F | D:185 | (-7.04, 11.29, -57.99) |
| 7:43843370 | V>L | D:186 | (-2.74, 12.42, -57.28) | |
| 7:43843380 | T>I | D:189 | (-1.13, 3.81, -63.50) | |
| 7:43843392 | R>Q | D:193 | (-2.16, -7.69, -72.20) | |
| 7:43843419 | T>K | D:202 | (-1.48, 2.01, -59.85) | |
| 7:43843421 | V>L | D:203 | (-4.40, 4.33, -57.59) | |
| 7:43843424 | C>S | D:204 | (-2.60, 7.70, -56.14) | |
| 7:43843433 | T>S | D:207 | (-6.24, 12.43, -47.06) | |
| 7:43843436 | E>Q | D:208 | (-8.47, 16.02, -46.29) | |
| 7:43846577 | P>T | D:212 | (-0.26, 9.23, -48.63) | |
| 7:43846578 | P>L | D:212 | (-0.26, 9.23, -48.63) | |
| 7:43846602 | G>V | D:220 | (-4.57, -12.88, -63.18) | |
| 7:43846605 | P>L | D:221 | (-3.44, -15.67, -64.73) | |
| 7:43846616 | COSM79143 | R>G | D:225 | (-10.21, -13.57, -54.46) |
| 7:43846660 | COSM1246135 | E>D | D:239 | (1.25, -5.13, -41.68) |
| 7:43846673 | V>I | D:244 | (-10.34, -11.97, -37.26) | |
| 7:43846674 | V>A | D:244 | (-10.34, -11.97, -37.26) | |
| 7:43846688 | rs373825735 | N>H | D:249 | (-24.24, -14.34, -42.78) |
| 7:43846712 | I>V | D:257 | (-29.14, -2.61, -43.94) | |
| 7:43846737 | rs368019075 | Q>R | D:265 | (-35.42, 2.40, -39.21) |
| 7:43846742 | S>P | D:267 | (-31.87, 8.93, -40.53) | |
| 7:43846757 | rs556754637 | A>T | D:272 | (-27.30, 11.22, -46.63) |
| 7:43846772 | rs138692014 | R>C | D:277 | (-20.22, 5.93, -49.17) |
| 7:43846773 | rs200862503 | R>H | D:277 | (-20.22, 5.93, -49.17) |
| 7:43846781 | H>Y | D:280 | (-16.40, 10.17, -53.02) | |
| 7:43846812 | rs142695242 | K>R | D:290 | (-9.86, 9.02, -67.08) |
| 7:43846815 | Y>C | D:291 | (-4.74, 10.35, -64.97) | |
| 7:43846821 | C>S | D:293 | (-7.24, 7.24, -70.31) | |
| 7:43846824 | rs147378665 | S>L | D:294 | (-5.10, 10.63, -70.55) |