Assessment of Structural Intolerance and Durability
General Structure Information 2i99 CRYM crystal structure of human mu_crystallin at 2.6 angstrom 2.6Å AUTH Z.CHENG,L.SUN,J.HE,W.GONGTITL CRYSTAL STRUCTURE OF HUMAN {MICRO}-CRYSTALLIN COMPLEXED WITHTITL 2 NADPHREF PROTEIN SCI. V. 16 329 2007REFN ISSN 0961-8368PMID 17242435DOI 10.1110/PS.062556907 Variant Set Distributions Mapped Variants
General Structure Information 2y05 PTGR1 crystal structure of human leukotriene b4 12-hydroxydehydrogenase in complex with nadp and raloxifene 2.2Å AUTH W.W.YUE,N.SHAFQAT,T.KROJER,A.C.W.PIKE,F.VON DELFT,R.SETHI,AUTH 2 P.SAVITSKY,C.JOHANSSON,C.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN LEUKOTRIENE B4TITL 2 12-HYDROXYDEHYDROGENASE IN COMPLEX WITH NADP AND RALOXIFENEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1djl NNT the crystal structure of human transhydrogenase domain iii with bound nadp 2.0Å AUTH S.A.WHITE,S.J.PEAKE,S.MCSWEENEY,G.LEONARD,N.P.COTTON,AUTH 2 J.B.JACKSONTITL THE HIGH-RESOLUTION STRUCTURE OF THE NADP(H)-BINDINGTITL 2 COMPONENT (DIII) OF PROTON-TRANSLOCATING TRANSHYDROGENASETITL 3 FROM HUMAN HEART MITOCHONDRIA.REF STRUCTURE FOLD.DES. V. 8 1 2000REFN ISSN 0969-2126PMID 10673423DOI 10.1016/S0969-2126(00)00075-7 Variant Set Distributions Mapped Variants
General Structure Information 2ypd JMJD1C crystal structure of the jumonji domain of human jumonji domain containing 1c protein 2.1Å AUTH M.VOLLMAR,C.JOHANSSON,T.KROJER,C.STRAIN-DAMERELL,S.FROESE,AUTH 2 E.WILLIAMS,D.COUTANDIN,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,AUTH 3 C.BOUNTRA,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE JUMONJI DOMAIN OF HUMAN JUMONJITITL 2 DOMAIN CONTAINING 1C PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2dyb NCF4 the crystal structure of human p40(phox) 3.15Å AUTH K.HONBOU,R.MINAKAMI,S.YUZAWA,R.TAKEYA,N.N.SUZUKI,AUTH 2 S.KAMAKURA,H.SUMIMOTO,F.INAGAKITITL FULL-LENGTH P40PHOX STRUCTURE SUGGESTS A BASIS FORTITL 2 REGULATION MECHANISM OF ITS MEMBRANE BINDING.REF EMBO J. V. 26 1176 2007REFN ISSN 0261-4189PMID 17290225DOI 10.1038/SJ.EMBOJ.7601561 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3w7r DHODH structure of human dihydroorotate dehydrogenase in complex with mii-4- 097 1.68Å AUTH D.K.INAOKA,M.IIDA,T.TABUCHI,N.LEE,S.HASHIMOTO,S.MATSUOKA,AUTH 2 T.KURANAGA,T.SHIBA,K.SAKAMOTO,S.SUZUKI,E.O.BALOGUN,T.NARA,AUTH 3 T.AOKI,M.INOUE,T.HONMA,A.TANAKA,S.HARADA,K.KITATITL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEXTITL 2 WITH MII-4-097REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3w7r DHODH structure of human dihydroorotate dehydrogenase in complex with mii-4- 097 1.68Å AUTH D.K.INAOKA,M.IIDA,T.TABUCHI,N.LEE,S.HASHIMOTO,S.MATSUOKA,AUTH 2 T.KURANAGA,T.SHIBA,K.SAKAMOTO,S.SUZUKI,E.O.BALOGUN,T.NARA,AUTH 3 T.AOKI,M.INOUE,T.HONMA,A.TANAKA,S.HARADA,K.KITATITL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEXTITL 2 WITH MII-4-097REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3w7r DHODH structure of human dihydroorotate dehydrogenase in complex with mii-4- 097 1.68Å AUTH D.K.INAOKA,M.IIDA,T.TABUCHI,N.LEE,S.HASHIMOTO,S.MATSUOKA,AUTH 2 T.KURANAGA,T.SHIBA,K.SAKAMOTO,S.SUZUKI,E.O.BALOGUN,T.NARA,AUTH 3 T.AOKI,M.INOUE,T.HONMA,A.TANAKA,S.HARADA,K.KITATITL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEXTITL 2 WITH MII-4-097REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3rcq ASPH crystal structure of human aspartate beta-hydroxylase isoform a 2.05Å AUTH T.KROJER,G.KOCHAN,E.PILKA,V.HOZJAN,C.K.ALLERSTON,J.BRAY,AUTH 2 J.R.MUNIZ,A.CHAIKUAD,O.GILEADI,K.KAVANAGH,F.VON DELFT,AUTH 3 C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN ASPARTATE BETA-HYDROXYLASETITL 2 ISOFORM AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3tkr PRDX4 crystal structure of full-length human peroxiredoxin 4 with t118e mutation 2.1Å AUTH X.WANG,L.WANG,X.WANG,F.SUN,C.-C.WANGTITL STRUCTURAL INSIGHTS INTO THE PEROXIDASE ACTIVITY ANDTITL 2 INACTIVATION OF HUMAN PEROXIREDOXIN 4REF BIOCHEM.J. 2011REFN ESSN 1470-8728PMID 21916849DOI 10.1042/BJ20110380 Variant Set Distributions Mapped Variants