General Structure Information
| PDB ID | 3w7r |
| HGNC Gene Label(s) | DHODH |
| Structure Name | structure of human dihydroorotate dehydrogenase in complex with mii-4- 097 |
| Resolution | 1.68Å |
| Reference | AUTH D.K.INAOKA,M.IIDA,T.TABUCHI,N.LEE,S.HASHIMOTO,S.MATSUOKA,AUTH 2 T.KURANAGA,T.SHIBA,K.SAKAMOTO,S.SUZUKI,E.O.BALOGUN,T.NARA,AUTH 3 T.AOKI,M.INOUE,T.HONMA,A.TANAKA,S.HARADA,K.KITATITL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEXTITL 2 WITH MII-4-097REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 367 |
| Number Of SNVs | 107 |
| Number Of Permutations | 31579 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.095 |
| p-value | 0.024 |
ClinVar
| Number Of Residues | 367 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1234 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.333 |
| p-value | 0.318 |
COSMIC
| Number Of Residues | 367 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1061 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.5 |
| p-value | 0.352 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 107 |
| Number Of ClinVar SNVs | 6 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.217 |
| p-value | 0.231 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 107 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.329 |
| p-value | 0.361 |