General Structure Information
| PDB ID | 1pl6 |
| HGNC Gene Label(s) | SORD |
| Structure Name | human sdh/nadh/inhibitor complex |
| Resolution | 2.0Å |
| Reference | AUTH T.A.PAULY,J.L.EKSTROM,D.A.BEEBE,B.CHRUNYK,D.CUNNINGHAM,AUTH 2 M.GRIFFOR,A.KAMATH,S.E.LEE,R.MADURA,D.MCGUIRE,T.SUBASHI,AUTH 3 D.WASILKO,P.WATTS,B.L.MYLARI,P.J.OATES,P.D.ADAMS,V.L.RATHTITL X-RAY CRYSTALLOGRAPHIC AND KINETIC STUDIES OF HUMAN SORBITOLTITL 2 DEHYDROGENASE.REF STRUCTURE V. 11 1071 2003REFN ISSN 0969-2126PMID 12962626DOI 10.1016/S0969-2126(03)00167-9 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 348 |
| Number Of SNVs | 59 |
| Number Of Permutations | 45910 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.036 |
| p-value | 0.052 |
COSMIC
| Number Of Residues | 348 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1128 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.1 |
| p-value | 0.754 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 59 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | -0.15 |
| p-value | 0.92 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
