Assessment of Structural Intolerance and Durability
General Structure Information 3kjd PARP2 human poly(adp-ribose) polymerase 2, catalytic fragment in complex with an inhibitor abt-888 1.95Å AUTH T.KARLBERG,M.HAMMARSTROM,P.SCHUTZ,L.SVENSSON,H.SCHULERTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PARP2 INTITL 2 COMPLEX WITH PARP INHIBITOR ABT-888.REF BIOCHEMISTRY V. 49 1056 2010REFN ISSN 0006-2960PMID 20092359DOI 10.1021/BI902079Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3gls SIRT3 crystal structure of human sirt3 2.7Å AUTH L.JIN,W.WEI,Y.JIANG,H.PENG,J.CAI,C.MAO,H.DAI,AUTH 2 W.CHOY,J.E.BEMIS,M.R.JIROUSEK,J.C.MILNE,AUTH 3 C.H.WESTPHAL,R.B.PERNITITL CRYSTAL STRUCTURES OF HUMAN SIRT3 DISPLAYINGTITL 2 SUBSTRATE-INDUCED CONFORMATIONAL CHANGES.REF J.BIOL.CHEM. V. 284 24394 2009REFN ISSN 0021-9258PMID 19535340DOI 10.1074/JBC.M109.014928 Variant Set Distributions Mapped Variants
General Structure Information 1nut NMNAT3 crystal structure of human cytosolic nmn/namn adenylyltransferase complexed with atp analog 1.9Å AUTH X.ZHANG,O.V.KURNASOV,S.KARTHIKEYAN,N.V.GRISHIN,A.L.OSTERMAN,AUTH 2 H.ZHANGTITL STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NAMNTITL 2 ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NADTITL 3 BIOSYNTHESISREF J.BIOL.CHEM. V. 278 13503 2003REFN ISSN 0021-9258PMID 12574164DOI 10.1074/JBC.M300073200 Variant Set Distributions Mapped Variants
General Structure Information 3gvp AHCYL2 human sahh-like domain of human adenosylhomocysteinase 3 2.25Å AUTH M.I.SIPONEN,M.WISNIEWSKA,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,M.MOCHE,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,J.SAGEMARK,P.SCHUTZ,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 7 H.SCHUELERTITL HUMAN S-ADENOSYL HOMOCYSTEINE HYDROLASE-LIKE 2TITL 2 PROTEIN CRYSTAL STRUCTUREREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2wm1 ACMSD the crystal structure of human alpha-amino-beta- carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between nad synthesis and glycolysis 2.01Å AUTH S.GARAVAGLIA,S.PEROZZI,L.GALEAZZI,N.RAFFAELLI,AUTH 2 M.RIZZITITL THE CRYSTAL STRUCTURE OF HUMAN ALPHA-AMINO-BETA-TITL 2 CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASETITL 3 IN COMPLEX WITH 1,3-DIHYDROXYACETONEPHOSPHATETITL 4 SUGGESTS A REGULATORY LINK BETWEEN NAD SYNTHESISTITL 5 […]
General Structure Information 3dl2 UEVLD hexagonal structure of the ldh domain of human ubiquitin- conjugating enzyme e2-like isoform a 2.1Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,E.M.NEWMAN,AUTH 2 P.J.FINERTY JR.,C.BUTLER-COLE,C.BOUNTRA,AUTH 3 M.WOLKSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 4 S.DHE-PAGANONTITL STRUCTURAL INVESTIGATION INTO THE L-LACTATETITL 2 DEHYDROGENASE DOMAIN OF HUMANTITL 3 UBIQUITIN-CONJUGATING ENZYME E2-LIKE ISOFORM A.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3hkv PARP10 human poly(adp-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide 2.1Å AUTH T.KARLBERG,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,A.KOTZSCH,T.K.NIELSEN,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,A.K.ROOS,J.SAGEMARK,P.SCHUTZ,AUTH 6 M.I.SIPONEN,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 8 H.SCHULERTITL HUMAN POLY(ADP-RIBOSE) POLYMERASE 10, CATALYTICTITL 2 FRAGMENT IN COMPLEX WITH AN INHIBITORTITL 3 3-AMINOBENZAMIDEREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 3qj4 RNLS crystal structure of human renalase (isoform 1) 2.5Å AUTH M.MILANI,F.CIRIELLO,S.BARONI,V.PANDINI,G.CANEVARI,AUTH 2 M.BOLOGNESI,A.ALIVERTITITL FAD-BINDING SITE AND NADP REACTIVITY IN HUMAN RENALASE: ATITL 2 NEW ENZYME INVOLVED IN BLOOD PRESSURE REGULATIONREF J.MOL.BIOL. V. 411 463 2011REFN ISSN 0022-2836PMID 21699903DOI 10.1016/J.JMB.2011.06.010 Variant Set Distributions Mapped Variants
General Structure Information 2hzp KYNU crystal structure of homo sapiens kynureninase 2.0Å AUTH S.LIMA,R.KHRISTOFOROV,C.MOMANY,R.S.PHILLIPSTITL CRYSTAL STRUCTURE OF HOMO SAPIENS KYNURENINASE.REF BIOCHEMISTRY V. 46 2735 2007REFN ISSN 0006-2960PMID 17300176DOI 10.1021/BI0616697 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3blj PARP15 crystal structure of human poly(adp-ribose) polymerase 15, catalytic fragment 2.2Å AUTH T.KARLBERG,M.KLEPSCH,A.G.THORSELL,C.D.ANDERSSON,A.LINUSSON,AUTH 2 H.SCHULERTITL STRUCTURAL BASIS FOR LACK OF ADP-RIBOSYLTRANSFERASE ACTIVITYTITL 2 IN POLY(ADP-RIBOSE) POLYMERASE-13/ZINC FINGER ANTIVIRALTITL 3 PROTEIN.REF J.BIOL.CHEM. V. 290 7336 2015REFN ISSN 0021-9258PMID 25635049DOI 10.1074/JBC.M114.630160 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]