General Structure Information 3kvo HSDL2 crystal structure of the catalytic domain of human hydroxysteroid dehydrogenase like 2 (hsdl2) 2.25Å AUTH E.UGOCHUKWU,C.BHATIA,J.HUANG,E.PILKA,J.R.C.MUNIZ,A.C.W.PIKE,AUTH 2 T.KROJER,F.VON DELFT,E.M.VERDIN,U.OPPERMANN,K.L.KAVANAGHTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMANTITL 2 HYDROXYSTEROID DEHYDROGENASE LIKE 2 (HSDL2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2vns STEAP3 crystal structure of the membrane proximal oxidoreductase domain of human steap3, the dominant ferric reductase of the erythroid transferrin cycle 2.0Å AUTH A.K.SENDAMARAI,R.S.OHGAMI,M.D.FLEMING,C.M.LAWRENCETITL STRUCTURE OF THE MEMBRANE PROXIMAL OXIDOREDUCTASETITL 2 DOMAIN OF HUMAN STEAP3, THE DOMINANTTITL 3 FERRIREDUCTASE OF THE ERYTHROID TRANSFERRIN CYCLEREF PROC.NATL.ACAD.SCI.USA V. 105 7410 2008REFN ISSN 0027-8424PMID […]
General Structure Information 2jbm QPRT qprtase structure from human 2.0Å AUTH H.LIU,K.WOZNICA,G.CATTON,A.CRAWFORD,N.BOTTINF,AUTH 2 J.H.NAISMITHTITL STRUCTURAL AND KINETIC CHARACTERIZATION OFTITL 2 QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (HQPRTASE)TITL 3 FROM HOMO SAPIENS.REF J.MOL.BIOL. V. 373 755 2007REFN ISSN 0022-2836PMID 17868694DOI 10.1016/J.JMB.2007.08.043 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ism BST1 crystal structure analysis of bst-1/cd157 complexed with nicotinamide 3.0Å AUTH S.YAMAMOTO-KATAYAMA,M.ARIYOSHI,K.ISHIHARA,T.HIRANO,AUTH 2 H.JINGAMI,K.MORIKAWATITL CRYSTALLOGRAPHIC STUDIES ON HUMAN BST-1/CD157 WITHTITL 2 ADP-RIBOSYL CYCLASE AND NAD GLYCOHYDROLASE ACTIVITIES.REF J.MOL.BIOL. V. 316 711 2002REFN ISSN 0022-2836PMID 11866528DOI 10.1006/JMBI.2001.5386 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2j6l ALDH7A1 structure of aminoadipate-semialdehyde dehydrogenase 1.3Å AUTH C.BROCKER,N.LASSEN,T.ESTEY,A.PAPPA,M.CANTORE,V.V.ORLOVA,AUTH 2 T.CHAVAKIS,K.L.KAVANAGH,U.OPPERMANN,V.VASILIOUTITL ALDEHYDE DEHYDROGENASE 7A1 (ALDH7A1) IS A NOVEL ENZYMETITL 2 INVOLVED IN CELLULAR DEFENSE AGAINST HYPEROSMOTIC STRESS.REF J.BIOL.CHEM. V. 285 18452 2010REFN ISSN 0021-9258PMID 20207735DOI 10.1074/JBC.M109.077925 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hhd FASN structure of the human fatty acid synthase ks-mat didomain as a framework for inhibitor design. 2.15Å AUTH G.PAPPENBERGER,J.BENZ,B.GSELL,M.HENNIG,A.RUF,AUTH 2 M.STIHLE,R.THOMA,M.G.RUDOLPHTITL STRUCTURE OF THE HUMAN FATTY ACID SYNTHASE KS-MATTITL 2 DIDOMAIN AS A FRAMEWORK FOR INHIBITOR DESIGN.REF J.MOL.BIOL. V. 397 508 2010REFN ISSN 0022-2836PMID 20132826DOI 10.1016/J.JMB.2010.01.066 Variant Set Distributions Ripley’s K […]
General Structure Information 2ckj XDH human milk xanthine oxidoreductase 3.59Å AUTH A.R.PEARSON,B.L.J.GODBER,R.EISENTHAL,G.L.TAYLOR,AUTH 2 R.HARRISONTITL HUMAN MILK XANTHINE DEHYDROGENASE IS INCOMPLETELYTITL 2 CONVERTED TO THE OXIDASE FORM IN THE ABSENCE OFTITL 3 PROTEOLYSIS. A STRUCTURAL EXPLANATION.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1rqd DHPS deoxyhypusine synthase holoenzyme in its low ionic strength, high ph crystal form with the inhibitor gc7 bound in the active site 3.0Å AUTH T.C.UMLAND,E.C.WOLFF,M.-H.PARK,D.R.DAVIESTITL A NEW CRYSTAL STRUCTURE OF DEOXYHYPUSINE SYNTHASE REVEALSTITL 2 THE CONFIGURATION OF THE ACTIVE ENZYME AND OF ANTITL 3 ENZYME-NAD-INHIBITOR TERNARY COMPLEXREF J.BIOL.CHEM. V. 279 28697 […]
General Structure Information 2w8r ALDH5A1 the crystal structure of human ssadh in complex with nad+ 2.4Å AUTH Y.-G.KIM,S.LEE,O.-S.KWON,S.-Y.PARK,S.-J.LEE,AUTH 2 B.-J.PARK,K.-J.KIMTITL REDOX-SWITCH MODULATION OF HUMAN SSADH BY DYNAMICTITL 2 CATALYTIC LOOP.REF EMBO J. V. 28 959 2009REFN ISSN 0261-4189PMID 19300440DOI 10.1038/EMBOJ.2009.40 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4oe5 ALDH4A1 structure of human aldh4a1 crystallized in space group p21 1.95Å AUTH T.A.PEMBERTON,D.SRIVASTAVA,N.SANYAL,M.T.HENZL,D.F.BECKER,AUTH 2 J.J.TANNERTITL STRUCTURAL STUDIES OF YEAST DELTATITL 2 (1)-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE (ALDH4A1): ACTIVETITL 3 SITE FLEXIBILITY AND OLIGOMERIC STATE.REF BIOCHEMISTRY V. 53 1350 2014REFN ISSN 0006-2960PMID 24502590DOI 10.1021/BI500048B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]