Assessment of Structural Intolerance and Durability
General Structure Information 3d7u CSK structural basis for the recognition of c-src by its inactivator csk 4.11Å AUTH N.M.LEVINSON,M.A.SEELIGER,P.A.COLE,J.KURIYANTITL STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITSTITL 2 INACTIVATOR CSK.REF CELL(CAMBRIDGE,MASS.) V. 134 124 2008REFN ISSN 0092-8674PMID 18614016DOI 10.1016/J.CELL.2008.05.051 Variant Set Distributions Mapped Variants
General Structure Information 1z6x ARF4 structure of human adp-ribosylation factor 4 2.7Å AUTH A.ATANASSOVA,J.CHOE,C.ARROWSMITH,A.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3a4o LYN lyn kinase domain 3.0Å AUTH N.MIYANO,T.KINOSHITA,R.NAKAI,Y.KIRII,K.YOKOTA,AUTH 2 T.TADATITL STRUCTURAL BASIS FOR THE INHIBITOR RECOGNITION OFTITL 2 HUMAN LYN KINASE DOMAINREF BIOORG.MED.CHEM.LETT. V. 19 6557 2009REFN ISSN 0960-894XPMID 19857964DOI 10.1016/J.BMCL.2009.10.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c0o HCK src family kinase hck with bound inhibitor a-770041 2.85Å AUTH A.BURCHAT,D.W.BORHANI,D.J.CALDERWOOD,G.C.HIRST,B.LI,AUTH 2 R.F.STACHLEWITZTITL DISCOVERY OF A-770041, A SRC-FAMILY SELECTIVE ORALLY ACTIVETITL 2 LCK INHIBITOR THAT PREVENTS ORGAN ALLOGRAFT REJECTION.REF BIOORG.MED.CHEM.LETT. V. 16 118 2006REFN ISSN 0960-894XPMID 16216497DOI 10.1016/J.BMCL.2005.09.039 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2zm1 LCK crystal structure of imidazo pyrazin 1 bound to the kinase domain of human lck, (auto-phosphorylated on tyr394) 2.1Å AUTH T.OZAWA,E.TSUJI,M.OZAWA,C.HANDA,H.MUKAIYAMA,AUTH 2 T.NISHIMURA,S.KOBAYASHI,K.OKAZAKITITL THE IMPORTANCE OF CH/PI HYDROGEN BONDS IN RATIONALTITL 2 DRUG DESIGN: AN AB INITIO FRAGMENT MOLECULARTITL 3 ORBITAL STUDY TO LEUKOCYTE-SPECIFIC PROTEINTITL 4 TYROSINE (LCK) KINASEREF BIOORG.MED.CHEM. V. […]
General Structure Information 3it8 TNF crystal structure of tnf alpha complexed with a poxvirus mhc-related tnf binding protein 2.8Å AUTH Z.YANG,A.P.WEST JR.,P.J.BJORKMANTITL CRYSTAL STRUCTURE OF TNFA COMPLEXED WITH A POXVIRUSTITL 2 MHC-RELATED TNF BINDING PROTEINREF NAT.STRUCT.MOL.BIOL.REFN ESSN 1545-9985DOI 10.1038/NSMB.1683 Variant Set Distributions Mapped Variants
General Structure Information 2buj STK16 crystal structure of the human serine-threonine kinase 16 in complex with staurosporine 2.6Å AUTH J.E.DEBRECZENI,J.ESWARAN,A.BULLOCK,P.FILIPPAKOPOULOS,AUTH 2 K.KAVANAGH,A.AMOS,O.FEDOROV,F.SOBOTT,L.J.BALL,F.VON DELFT,AUTH 3 C.ARROWSMITH,M.SUNDSTROM,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16TITL 2 IN COMPLEX WITH STAUROSPORINEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3bh7 RP2 crystal structure of the rp2-arl3 complex bound to gdp-alf4 1.9Å AUTH S.VELTEL,R.GASPER,E.EISENACHER,A.WITTINGHOFERTITL THE RETINITIS PIGMENTOSA 2 GENE PRODUCT IS ATITL 2 GTPASE-ACTIVATING PROTEIN FOR ARF-LIKE 3REF NAT.STRUCT.MOL.BIOL. V. 15 373 2008REFN ISSN 1545-9993PMID 18376416DOI 10.1038/NSMB.1396 Variant Set Distributions Mapped Variants