General Structure Information 3mdv CYP46A1 clotrimazole complex of cytochrome p450 46a1 2.4Å AUTH N.MAST,C.CHARVET,I.A.PIKULEVA,C.D.STOUTTITL STRUCTURAL BASIS OF DRUG BINDING TO CYP46A1, AN ENZYME THATTITL 2 CONTROLS CHOLESTEROL TURNOVER IN THE BRAIN.REF J.BIOL.CHEM. V. 285 31783 2010REFN ISSN 0021-9258PMID 20667828DOI 10.1074/JBC.M110.143313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3t3s CYP2A13 human cytochrome p450 2a13 in complex with pilocarpine 3.0Å AUTH N.M.DEVORE,K.M.MENEELY,A.G.BART,E.S.STEPHENS,K.P.BATTAILE,AUTH 2 E.E.SCOTTTITL STRUCTURAL COMPARISON OF CYTOCHROMES P450 2A6, 2A13, AND 2E1TITL 2 WITH PILOCARPINE.REF FEBS J. V. 279 1621 2012REFN ISSN 1742-464XPMID 22051186DOI 10.1111/J.1742-4658.2011.08412.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3czh CYP2R1 crystal structure of cyp2r1 in complex with vitamin d2 2.3Å AUTH N.V.STRUSHKEVICH,W.TEMPEL,A.A.GILEP,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF CYP2R1 IN COMPLEX WITHTITL 2 VITAMIN D2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ld6 CYP51A1 crystal structure of human lanosterol 14alpha-demethylase (cyp51) in complex with ketoconazole 2.8Å AUTH N.STRUSHKEVICH,S.A.USANOV,H.W.PARKTITL STRUCTURAL BASIS OF HUMAN CYP51 INHIBITION BY ANTIFUNGALTITL 2 AZOLES.REF J.MOL.BIOL. V. 397 1067 2010REFN ISSN 0022-2836PMID 20149798DOI 10.1016/J.JMB.2010.01.075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4gqs CYP2C19 structure of human microsomal cytochrome p450 (cyp) 2c19 2.87Å AUTH R.L.REYNALD,S.SANSEN,C.D.STOUT,E.F.JOHNSONTITL STRUCTURAL CHARACTERIZATION OF HUMAN CYTOCHROME P450 2C19:TITL 2 ACTIVE SITE DIFFERENCES BETWEEN P450S 2C8, 2C9, AND 2C19.REF J.BIOL.CHEM. V. 287 44581 2012REFN ISSN 0021-9258PMID 23118231DOI 10.1074/JBC.M112.424895 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3ua5 CYP2B6 crystal structure of p450 2b6 (y226h/k262r) in complex with two molecules of amlodipine 2.8Å AUTH M.B.SHAH,P.R.WILDERMAN,J.PASCUAL,Q.ZHANG,C.D.STOUT,AUTH 2 J.R.HALPERTTITL CONFORMATIONAL ADAPTATION OF HUMAN CYTOCHROME P450 2B6 ANDTITL 2 RABBIT CYTOCHROME P450 2B4 REVEALED UPON BINDING MULTIPLETITL 3 AMLODIPINE MOLECULES.REF BIOCHEMISTRY V. 51 7225 2012REFN ISSN 0006-2960PMID 22909231DOI 10.1021/BI300894Z Variant Set Distributions […]
General Structure Information 4dvq CYP11B2 structure of human aldosterone synthase, cyp11b2, in complex with deoxycorticosterone 2.49Å AUTH N.STRUSHKEVICH,A.A.GILEP,L.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 S.A.USANOV,H.W.PARKTITL STRUCTURAL INSIGHTS INTO ALDOSTERONE SYNTHASE SUBSTRATETITL 2 SPECIFICITY AND TARGETED INHIBITION.REF MOL.ENDOCRINOL. V. 27 315 2013REFN ISSN 0888-8809PMID 23322723DOI 10.1210/ME.2012-1287 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4k9w CYP3A4 complex of human cyp3a4 with a desoxyritonavir analog 2.4Å AUTH I.F.SEVRIOUKOVA,T.L.POULOSTITL DISSECTING CYTOCHROME P450 3A4-LIGAND INTERACTIONS USINGTITL 2 RITONAVIR ANALOGUES.REF BIOCHEMISTRY V. 52 4474 2013REFN ISSN 0006-2960PMID 23746300DOI 10.1021/BI4005396 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3eqm CYP19A1 crystal structure of human placental aromatase cytochrome p450 in complex with androstenedione 2.9Å AUTH D.GHOSH,J.GRISWOLD,M.ERMAN,W.PANGBORNTITL STRUCTURAL BASIS FOR ANDROGEN SPECIFICITY AND OESTROGENTITL 2 SYNTHESIS IN HUMAN AROMATASE.REF NATURE V. 457 219 2009REFN ISSN 0028-0836PMID 19129847DOI 10.1038/NATURE07614 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1og2 CYP2C9 structure of human cytochrome p450 cyp2c9 2.6Å AUTH P.A.WILLIAMS,J.COSME,A.WARD,H.C.ANGOVE,AUTH 2 D.MATAK VINKOVIC,H.JHOTITITL CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 2C9TITL 2 WITH BOUND WARFARINREF NATURE V. 424 464 2003REFN ISSN 0028-0836PMID 12861225DOI 10.1038/NATURE01862 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants