Assessment of Structural Intolerance and Durability
General Structure Information 1z10 CYP2A6 crystal structure of human microsomal p450 2a6 with coumarin bound 1.9Å AUTH J.K.YANO,M.H.HSU,K.J.GRIFFIN,C.D.STOUT,E.F.JOHNSONTITL STRUCTURES OF HUMAN MICROSOMAL CYTOCHROME P450 2A6 COMPLEXEDTITL 2 WITH COUMARIN AND METHOXSALENREF NAT.STRUCT.MOL.BIOL. V. 12 822 2005REFN ISSN 1545-9993PMID 16086027DOI 10.1038/NSMB971 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lc4 CYP2E1 human cytochrome p450 2e1 in complex with omega-imidazolyl-dodecanoic acid 3.1Å AUTH P.R.PORUBSKY,K.P.BATTAILE,E.E.SCOTTTITL HUMAN CYTOCHROME P450 2E1 STRUCTURES WITH FATTY ACID ANALOGSTITL 2 REVEAL A PREVIOUSLY UNOBSERVED BINDING MODE.REF J.BIOL.CHEM. V. 285 22282 2010REFN ISSN 0021-9258PMID 20463018DOI 10.1074/JBC.M110.109017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4i8v CYP1A1 human cytochrome p450 1a1 in complex with alpha-naphthoflavone 2.6Å AUTH A.A.WALSH,G.D.SZKLARZ,E.E.SCOTTTITL HUMAN CYTOCHROME P450 1A1 STRUCTURE AND UTILITY INTITL 2 UNDERSTANDING DRUG AND XENOBIOTIC METABOLISM.REF J.BIOL.CHEM. V. 288 12932 2013REFN ISSN 0021-9258PMID 23508959DOI 10.1074/JBC.M113.452953 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ruk CYP17A1 human cytochrome p450 cyp17a1 in complex with abiraterone 2.6Å AUTH N.M.DEVORE,E.E.SCOTTTITL STRUCTURES OF CYTOCHROME P450 17A1 WITH PROSTATE CANCERTITL 2 DRUGS ABIRATERONE AND TOK-001.REF NATURE V. 482 116 2012REFN ISSN 0028-0836PMID 22266943DOI 10.1038/NATURE10743 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2hi4 CYP1A2 crystal structure of human microsomal p450 1a2 in complex with alpha-naphthoflavone 1.95Å AUTH S.SANSEN,J.K.YANO,R.L.REYNALD,G.A.SCHOCH,AUTH 2 K.J.GRIFFIN,C.D.STOUT,E.F.JOHNSONTITL ADAPTATIONS FOR THE OXIDATION OF POLYCYCLICTITL 2 AROMATIC HYDROCARBONS EXHIBITED BY THE STRUCTURETITL 3 OF HUMAN P450 1A2.REF J.BIOL.CHEM. V. 282 14348 2007REFN ISSN 0021-9258PMID 17311915DOI 10.1074/JBC.M611692200 Variant Set Distributions Ripley’s K Analysis Plots […]