Assessment of Structural Intolerance and Durability
General Structure Information 2wk3 IDE crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42) 2.59Å AUTH Q.GUO,M.MANOLOPOULOU,Y.BIAN,A.B.SCHILLING,W.J.TANGTITL MOLECULAR BASIS FOR THE RECOGNITION AND CLEAVAGESTITL 2 OF IGF-II, TGF-ALPHA, AND AMYLIN BY HUMAN INSULINTITL 3 DEGRADING ENZYME.REF J.MOL.BIOL. V. 395 430 2010REFN ISSN 0022-2836PMID 19896952DOI 10.1016/J.JMB.2009.10.072 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4fys ANPEP human aminopeptidase n (cd13) in complex with angiotensin iv 2.01Å AUTH A.H.WONG,D.ZHOU,J.M.RINITITL THE X-RAY CRYSTAL STRUCTURE OF HUMAN AMINOPEPTIDASE NTITL 2 REVEALS A NOVEL DIMER AND THE BASIS FOR PEPTIDE PROCESSING.REF J.BIOL.CHEM. V. 287 36804 2012REFN ISSN 0021-9258PMID 22932899DOI 10.1074/JBC.M112.398842 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3edh BMP1 crystal structure of bone morphogenetic protein 1 protease domain in complex with partially bound dmso 1.25Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1r1j MME structural analysis of neprilysin with various specific and potent inhibitors 2.35Å AUTH C.OEFNER,B.P.ROQUES,M.C.FOURNIE-ZALUSKI,G.E.DALETITL STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC ANDTITL 2 POTENT INHIBITORS.REF ACTA CRYSTALLOGR.,SECT.D V. 60 392 2004REFN ISSN 0907-4449PMID 14747736DOI 10.1107/S0907444903027410 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mmp MMP7 matrilysin complexed with carboxylate inhibitor 2.3Å AUTH M.F.BROWNER,W.W.SMITH,A.L.CASTELHANOTITL MATRILYSIN-INHIBITOR COMPLEXES: COMMON THEMESTITL 2 AMONG METALLOPROTEASES.REF BIOCHEMISTRY V. 34 6602 1995REFN ISSN 0006-2960PMID 7756291DOI 10.1021/BI00020A004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1slm MMP3 crystal structure of fibroblast stromelysin-1: the c-truncated human proenzyme 1.9Å AUTH J.W.BECKER,A.I.MARCY,L.L.ROKOSZ,M.G.AXEL,J.J.BURBAUM,AUTH 2 P.M.FITZGERALD,P.M.CAMERON,C.K.ESSER,W.K.HAGMANN,J.D.HERMES,AUTH 3 J.P.SPRINGERTITL STROMELYSIN-1: THREE-DIMENSIONAL STRUCTURE OF THE INHIBITEDTITL 2 CATALYTIC DOMAIN AND OF THE C-TRUNCATED PROENZYME.REF PROTEIN SCI. V. 4 1966 1995REFN ISSN 0961-8368PMID 8535233 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1gxd MMP2 prommp-2/timp-2 complex 3.1Å AUTH E.MORGUNOVA,A.TUUTTILA,U.BERGMANN,K.TRYGGVASONTITL STRUCTURAL INSIGHT INTO THE COMPLEX FORMATION OF LATENTTITL 2 MATRIX METALLOPROTEINASE 2 WITH TISSUE INHIBITOR OFTITL 3 METALLOPROTEINASE 2REF PROC.NATL.ACAD.SCI.USA V. 99 7414 2002REFN ISSN 0027-8424PMID 12032297DOI 10.1073/PNAS.102185399 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fuk LTA4H leukotriene a4 hydrolase in complex with 1-[2-(1h-indol-5- yloxy)ethyl]piperidine-4-carboxylic acid 1.95Å AUTH D.R.DAVIES,B.MAMAT,O.T.MAGNUSSON,J.CHRISTENSEN,AUTH 2 M.H.HARALDSSON,R.MISHRA,B.PEASE,E.HANSEN,J.SINGH,AUTH 3 D.ZEMBOWER,H.KIM,A.S.KISELYOV,A.B.BURGIN,AUTH 4 M.E.GURNEY,L.J.STEWARTTITL DISCOVERY OF LEUKOTRIENE A4 HYDROLASE INHIBITORSTITL 2 USING METABOLOMICS BIASED FRAGMENT CRYSTALLOGRAPHY.REF J.MED.CHEM. V. 52 4694 2009REFN ISSN 0022-2623PMID 19618939DOI 10.1021/JM900259H Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3edi TLL1 crystal structure of tolloid-like protease 1 (tll-1) protease domain 1.4Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants