Assessment of Structural Intolerance and Durability
General Structure Information 3ff3 NAALAD2 the high resolution structure of human glutamate carboxypeptidase iii (gcpiii/naaladase ii) in complex with l-glutamate 1.37Å AUTH K.HLOUCHOVA,C.BARINKA,J.KONVALINKA,J.LUBKOWSKITITL STRUCTURAL INSIGHT INTO THE EVOLUTIONARY AND PHARMACOLOGICTITL 2 HOMOLOGY OF GLUTAMATE CARBOXYPEPTIDASES II AND IIIREF FEBS J. V. 276 4448 2009REFN ISSN 1742-464XPMID 19678840DOI 10.1111/J.1742-4658.2009.07152.X Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2boa CPA4 human procarboxypeptidase a4. 2.2Å AUTH R.GARCIA-CASTELLANOS,R.BONET-FIGUEREDO,I.PALLARES,AUTH 2 S.VENTURA,F.X.AVILES,J.VENDRELL,F.X.GOMIS-RUTHTITL DETAILED MOLECULAR COMPARISON BETWEEN THETITL 2 INHIBITION MODE OF A/B-TYPE CARBOXYPEPTIDASES INTITL 3 THE ZYMOGEN STATE AND BY THE ENDOGENOUS INHIBITORTITL 4 LATEXIN.REF CELL.MOL.LIFE SCI. V. 62 1996 2005REFN ISSN 1420-682XPMID 16091843DOI 10.1007/S00018-005-5174-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2rjq ADAMTS5 crystal structure of adamts5 with inhibitor bound 2.6Å AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,T.MCDONAGH,AUTH 2 S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,E.L.REIFENBERG,AUTH 3 L.A.COLLINS-RACIE,C.CORCORAN,B.FREEMAN,R.ZOLLNER,T.MARVELL,AUTH 4 M.VERA,P.E.SUM,E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECAN DEGRADINGTITL 2 ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3ctz XPNPEP1 structure of human cytosolic x-prolyl aminopeptidase 1.6Å AUTH X.LI,Z.LOU,X.LI,W.ZHOU,M.MA,Y.CAO,Y.GENG,M.BARTLAM,AUTH 2 X.C.ZHANG,Z.RAOTITL STRUCTURE OF HUMAN CYTOSOLIC X-PROLYL AMINOPEPTIDASE: ATITL 2 DOUBLE MN(II)-DEPENDENT DIMERIC ENZYME WITH A NOVELTITL 3 THREE-DOMAIN SUBUNITREF J.BIOL.CHEM. V. 283 22858 2008REFN ISSN 0021-9258PMID 18515364DOI 10.1074/JBC.M710274200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1r55 ADAM33 crystal structure of the catalytic domain of human adam 33 1.58Å AUTH P.ORTH,P.REICHERT,W.WANG,W.W.PROSISE,T.YAROSH-TOMAINE,AUTH 2 G.HAMMOND,L.XIAO,U.A.MIRZA,J.ZOU,C.STRICKLAND,S.S.TAREMI,AUTH 3 H.V.LE,V.MADISONTITL CRYSTAL STRUCTRE OF THE CATALYTIC DOMAIN OF HUMAN ADAM33REF J.MOL.BIOL. V. 335 129 2004REFN ISSN 0022-2836PMID 14659745DOI 10.1016/J.JMB.2003.10.037 Variant Set Distributions Mapped Variants
General Structure Information 2bo9 LXN human carboxypeptidase a4 in complex with human latexin. 1.6Å AUTH I.PALLARES,R.BONET,R.GARCIA-CASTELLANOS,S.VENTURA,AUTH 2 F.X.AVILES,J.VENDRELL,F.X.GOMIS-RUETHTITL STRUCTURE OF HUMAN CARBOXYPEPTIDASE A4 WITH ITSTITL 2 ENDOGENOUS PROTEIN INHIBITOR, LATEXIN.REF PROC.NATL.ACAD.SCI.USA V. 102 3978 2005REFN ISSN 0027-8424PMID 15738388DOI 10.1073/PNAS.0500678102 Variant Set Distributions Mapped Variants
General Structure Information 3dlj CNDP1 crystal structure of human carnosine dipeptidase 1 2.26Å AUTH E.DOBROVETSKY,A.DONG,A.SEITOVA,H.HE,W.TEMPEL,I.KOZIERADZKI,AUTH 2 C.H.ARROWSMITH,J.WEIGELT,C.BOUNTRA,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 D.COSSARTITL CRYSTAL STRUCTURE OF HUMAN CARNOSINE DIPEPTIDASE 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3d68 CPB2 crystal structure of a t325i/t329i/h333y/h335q mutant of thrombin- activatable fibrinolysis inhibitor (tafi-iiyq) 2.8Å AUTH P.F.MARX,T.H.BRONDIJK,T.PLUG,R.A.ROMIJN,W.HEMRIKA,AUTH 2 J.C.M.MEIJERS,E.G.HUIZINGATITL CRYSTAL STRUCTURES OF TAFI ELUCIDATE THE INACTIVATIONTITL 2 MECHANISM OF ACTIVATED TAFI: A NOVEL MECHANISM FOR ENZYMETITL 3 AUTOREGULATIONREF BLOOD V. 112 2803 2008REFN ISSN 0006-4971PMID 18559974DOI 10.1182/BLOOD-2008-03-146001 Variant Set Distributions Ripley’s K […]
General Structure Information 3bxm FOLH1 structure of an inactive mutant of human glutamate carboxypeptidase ii [gcpii(e424a)] in complex with n-acetyl-asp-glu (naag) 1.71Å AUTH V.KLUSAK,C.BARINKA,A.PLECHANOVOVA,P.MLCOCHOVA,J.KONVALINKA,AUTH 2 L.RULISEK,J.LUBKOWSKITITL REACTION MECHANISM OF GLUTAMATE CARBOXYPEPTIDASE II REVEALEDTITL 2 BY MUTAGENESIS, X-RAY CRYSTALLOGRAPHY, AND COMPUTATIONALTITL 3 METHODS.REF BIOCHEMISTRY V. 48 4126 2009REFN ISSN 0006-2960PMID 19301871DOI 10.1021/BI900220S Variant Set Distributions Ripley’s […]
General Structure Information 3bxm FOLH1 structure of an inactive mutant of human glutamate carboxypeptidase ii [gcpii(e424a)] in complex with n-acetyl-asp-glu (naag) 1.71Å AUTH V.KLUSAK,C.BARINKA,A.PLECHANOVOVA,P.MLCOCHOVA,J.KONVALINKA,AUTH 2 L.RULISEK,J.LUBKOWSKITITL REACTION MECHANISM OF GLUTAMATE CARBOXYPEPTIDASE II REVEALEDTITL 2 BY MUTAGENESIS, X-RAY CRYSTALLOGRAPHY, AND COMPUTATIONALTITL 3 METHODS.REF BIOCHEMISTRY V. 48 4126 2009REFN ISSN 0006-2960PMID 19301871DOI 10.1021/BI900220S Variant Set Distributions Ripley’s […]