Assessment of Structural Intolerance and Durability
General Structure Information 2v55 RND3 mechanism of multi-site phosphorylation from a rock-i:rhoe complex structure 3.7Å AUTH D.KOMANDER,R.GARG,P.T.C.WAN,A.J.RIDLEY,D.BARFORDTITL MECHANISM OF MULTI-SITE PHOSPHORYLATION FROM ATITL 2 ROCK-I:RHOE COMPLEX STRUCTURE.REF EMBO J. V. 27 3175 2008REFN ISSN 0261-4189PMID 18946488DOI 10.1038/EMBOJ.2008.226 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2x4x BRPF1 molecular basis of histone h3k36me3 recognition by the pwwp domain of brpf1. 1.85Å AUTH A.VEZZOLI,N.BONADIES,M.D.ALLEN,S.M.V.FREUND,AUTH 2 C.M.SANTIVERI,B.KVINLAUG,B.J.P.HUNTLY,B.GOTTGENS,AUTH 3 M.BYCROFTTITL MOLECULAR BASIS OF HISTONE H3K36ME3 RECOGNITION BYTITL 2 THE PWWP DOMAIN OF BRPF1.REF NAT.STRUCT.MOL.BIOL. V. 17 617 2010REFN ISSN 1545-9993PMID 20400950DOI 10.1038/NSMB.1797 Variant Set Distributions Mapped Variants
General Structure Information 3efh PRPS1 crystal structure of human phosphoribosyl pyrophosphate synthetase 1 2.6Å AUTH X.PENG,X.LITITL CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYLTITL 2 PYROPHOSPHATE SYNTHETASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2xeu RNF4 ring domain 1.5Å AUTH A.PLECHANOVOVA,E.G.JAFFRAY,S.A.MCMAHON,K.A.JOHNSON,AUTH 2 I.NAVRATILOVA,J.H.NAISMITH,R.T.HAYTITL MECHANISM OF UBIQUITYLATION BY DIMERIC RING LIGASE RNF4REF NAT.STRUCT.MOL.BIOL. V. 18 1052 2011REFN ISSN 1545-9993PMID 21857666DOI 10.1038/NSMB.2108 Variant Set Distributions Mapped Variants
General Structure Information 3g76 XIAP crystal structure of xiap-bir3 in complex with a bivalent compound 3.0Å AUTH F.COSSU,M.MILANI,E.MASTRANGELO,P.VACHETTE,AUTH 2 F.SERVIDA,D.LECIS,G.CANEVARI,D.DELIA,C.DRAGO,AUTH 3 V.RIZZO,L.MANZONI,P.SENECI,C.SCOLASTICO,M.BOLOGNESITITL STRUCTURAL BASIS FOR BIVALENT SMAC-MIMETICSTITL 2 RECOGNITION IN THE IAP PROTEIN FAMILYREF J.MOL.BIOL. V. 392 630 2009REFN ISSN 0022-2836PMID 19393243DOI 10.1016/J.JMB.2009.04.033 Variant Set Distributions Mapped Variants
General Structure Information 2vjf MDM2 crystal structure of the mdm2-mdmx ring domain heterodimer 2.3Å AUTH K.LINKE,P.D.MACE,C.A.SMITH,D.L.VAUX,J.SILKE,C.L.DAYTITL STRUCTURE OF THE MDM2/MDMX RING DOMAIN HETERODIMERTITL 2 REVEALS DIMERIZATION IS REQUIRED FOR THEIRTITL 3 UBIQUITYLATION IN TRANS.REF CELL DEATH DIFFER. V. 15 841 2008REFN ISSN 1350-9047PMID 18219319DOI 10.1038/SJ.CDD.4402309 Variant Set Distributions Mapped Variants
General Structure Information 3c7x MMP14 hemopexin-like domain of matrix metalloproteinase 14 1.7Å AUTH A.TOCHOWICZ,P.GOETTIG,R.EVANS,R.VISSE,Y.SHITOMI,R.PALMISANO,AUTH 2 N.ITO,K.RICHTER,K.MASKOS,D.FRANKE,D.SVERGUN,H.NAGASE,W.BODE,AUTH 3 Y.ITOHTITL THE DIMER INTERFACE OF THE MEMBRANE TYPE 1 MATRIXTITL 2 METALLOPROTEINASE HEMOPEXIN DOMAIN: CRYSTAL STRUCTURE ANDTITL 3 BIOLOGICAL FUNCTIONSREF J.BIOL.CHEM. V. 286 7587 2011REFN ISSN 0021-9258PMID 21193411DOI 10.1074/JBC.M110.178434 Variant Set Distributions Mapped Variants
General Structure Information 2xcv NT5C2 crystal structure of the d52n variant of cytosolic 5- nucleotidase ii in complex with inosine monophosphate and 2,3-bisphosphoglycerate 2.3Å AUTH K.WALLDEN,P.NORDLUNDTITL STRUCTURAL BASIS FOR THE ALLOSTERIC REGULATION ANDTITL 2 SUBSTRATE RECOGNITION OF HUMAN CYTOSOLIC 5-NUCLEOTIDASE IIREF J.MOL.BIOL. V. 408 684 2011REFN ISSN 0022-2836PMID 21396942DOI 10.1016/J.JMB.2011.02.059 Variant Set Distributions Ripley’s K […]
General Structure Information 3l2p LIG3 human dna ligase iii recognizes dna ends by dynamic switching between two dna bound states 3.0Å AUTH E.COTNER-GOHARA,I.K.KIM,M.HAMMEL,J.A.TAINER,A.E.TOMKINSON,AUTH 2 T.ELLENBERGERTITL HUMAN DNA LIGASE III RECOGNIZES DNA ENDS BY DYNAMICTITL 2 SWITCHING BETWEEN TWO DNA-BOUND STATES.REF BIOCHEMISTRY V. 49 6165 2010REFN ISSN 0006-2960PMID 20518483DOI 10.1021/BI100503W Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2ckj XDH human milk xanthine oxidoreductase 3.59Å AUTH A.R.PEARSON,B.L.J.GODBER,R.EISENTHAL,G.L.TAYLOR,AUTH 2 R.HARRISONTITL HUMAN MILK XANTHINE DEHYDROGENASE IS INCOMPLETELYTITL 2 CONVERTED TO THE OXIDASE FORM IN THE ABSENCE OFTITL 3 PROTEOLYSIS. A STRUCTURAL EXPLANATION.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants