Assessment of Structural Intolerance and Durability
General Structure Information 3dxc APBB1 crystal structure of the intracellular domain of human app in complex with fe65-ptb2 2.1Å AUTH J.RADZIMANOWSKI,B.SIMON,M.SATTLER,K.BEYREUTHER,AUTH 2 I.SINNING,K.WILDTITL STRUCTURE OF THE INTRACELLULAR DOMAIN OF THETITL 2 AMYLOID PRECURSOR PROTEIN IN COMPLEX WITHTITL 3 FE65-PTB2.REF EMBO REP. V. 9 1134 2008REFN ISSN 1469-221XPMID 18833287DOI 10.1038/EMBOR.2008.188 Variant Set Distributions Mapped Variants
General Structure Information 3f1i HGS human escrt-0 core complex 2.3Å AUTH X.REN,D.P.KLOER,Y.C.KIM,R.GHIRLANDO,L.F.SAIDI,G.HUMMER,AUTH 2 J.H.HURLEYTITL HYBRID STRUCTURAL MODEL OF THE COMPLETE HUMAN ESCRT-0TITL 2 COMPLEX.REF STRUCTURE V. 17 406 2009REFN ISSN 0969-2126PMID 19278655DOI 10.1016/J.STR.2009.01.012 Variant Set Distributions Mapped Variants
General Structure Information 2jun MID1 structure of the mid1 tandem b-boxes reveals an interaction reminiscent of intermolecular ring heterodimers -1.0Å AUTH H.TAO,B.N.SIMMONS,S.SINGIREDDY,M.JAKKIDI,K.M.SHORT,AUTH 2 T.C.COX,M.A.MASSIAHTITL STRUCTURE OF THE MID1 TANDEM B-BOXES REVEALS ANTITL 2 INTERACTION REMINISCENT OF INTERMOLECULAR RINGTITL 3 HETERODIMERSREF BIOCHEMISTRY V. 47 2450 2008REFN ISSN 0006-2960PMID 18220417DOI 10.1021/BI7018496 Variant Set Distributions Mapped Variants
General Structure Information 3keu PDXK crystal structure of human pl kinase with bound plp and atp 2.1Å AUTH A.K.GANDHI,F.N.MUSAYEV,M.K.SAFOTITL CRYSTAL STRUCTURE OF PL KINASE IN COMPLEX WITH MGATP ANDTITL 2 PLP: STRUCTURAL BASIS OF SEVERE INDUCED MGATP SUBSTRATETITL 3 INHIBITION OF THE ENZYMEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ifa FBP2 human muscle fructose-1,6-bisphosphatase e69q mutant in complex with amp 1.93Å AUTH M.ZARZYCKI,R.KOLODZIEJCZYK,E.MACIASZCZYK-DZIUBINSKA,AUTH 2 R.WYSOCKI,M.JASKOLSKI,A.DZUGAJTITL STRUCTURE OF E69Q MUTANT OF HUMAN MUSCLETITL 2 FRUCTOSE-1,6-BISPHOSPHATASEREF ACTA CRYSTALLOGR.,SECT.D V. 67 1028 2011REFN ISSN 0907-4449PMID 22120740DOI 10.1107/S090744491104385X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4kp5 CA12 crystal structure of catalytic domain of human carbonic anhydrase isozyme xii with 2-chloro-4-[(pyrimidin-2-ylsulfanyl) acetyl]benzenesulfonamide 1.45Å AUTH E.CAPKAUSKAITE,A.ZUBRIENE,A.SMIRNOV,J.TORRESAN,M.KISONAITE,AUTH 2 J.KAZOKAITE,J.GYLYTE,V.MICHAILOVIENE,V.JOGAITE,E.MANAKOVA,AUTH 3 S.GRAZULIS,S.TUMKEVICIUS,D.MATULISTITL BENZENESULFONAMIDES WITH PYRIMIDINE MOIETY AS INHIBITORS OFTITL 2 HUMAN CARBONIC ANHYDRASES I, II, VI, VII, XII, AND XIIIREF BIOORG.MED.CHEM. V. 21 6937 2013REFN ISSN 0968-0896PMID 24103428DOI 10.1016/J.BMC.2013.09.029 Variant Set […]
General Structure Information 2wl1 MEFV pyrin pryspry domain 1.35Å AUTH C.WEINERT,C.GRUETTER,H.ROSCHITZKI-VOSER,P.R.MITTL,AUTH 2 M.G.GRUETTERTITL THE CRYSTAL STRUCTURE OF HUMAN PYRIN B30.2 DOMAIN:TITL 2 IMPLICATIONS FOR MUTATIONS ASSOCIATED WITHTITL 3 FAMILIAL MEDITERRANEAN FEVER.REF J.MOL.BIOL. V. 394 226 2009REFN ISSN 0022-2836PMID 19729025DOI 10.1016/J.JMB.2009.08.059 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants