Assessment of Structural Intolerance and Durability
General Structure Information 3gls SIRT3 crystal structure of human sirt3 2.7Å AUTH L.JIN,W.WEI,Y.JIANG,H.PENG,J.CAI,C.MAO,H.DAI,AUTH 2 W.CHOY,J.E.BEMIS,M.R.JIROUSEK,J.C.MILNE,AUTH 3 C.H.WESTPHAL,R.B.PERNITITL CRYSTAL STRUCTURES OF HUMAN SIRT3 DISPLAYINGTITL 2 SUBSTRATE-INDUCED CONFORMATIONAL CHANGES.REF J.BIOL.CHEM. V. 284 24394 2009REFN ISSN 0021-9258PMID 19535340DOI 10.1074/JBC.M109.014928 Variant Set Distributions Mapped Variants
General Structure Information 3v4j APOBEC3G first-in-class small molecule inhibitors of the single-strand dna cytosine deaminase apobec3g 2.04Å AUTH M.LI,S.M.SHANDILYA,M.A.CARPENTER,A.RATHORE,W.L.BROWN,AUTH 2 A.L.PERKINS,D.A.HARKI,J.SOLBERG,D.J.HOOK,K.K.PANDEY,AUTH 3 M.A.PARNIAK,J.R.JOHNSON,N.J.KROGAN,M.SOMASUNDARAN,A.ALI,AUTH 4 C.A.SCHIFFER,R.S.HARRISTITL FIRST-IN-CLASS SMALL MOLECULE INHIBITORS OF THETITL 2 SINGLE-STRAND DNA CYTOSINE DEAMINASE APOBEC3G.REF ACS CHEM.BIOL. V. 7 506 2012REFN ISSN 1554-8929PMID 22181350DOI 10.1021/CB200440Y Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3d2s MBNL1 crystal structure of mbnl1 tandem zinc finger 3 and 4 domain in complex with cgcugu rna 1.7Å AUTH M.TEPLOVA,D.J.PATELTITL STRUCTURAL INSIGHTS INTO RNA RECOGNITION BY THETITL 2 ALTERNATIVE-SPLICING REGULATOR MUSCLEBLIND-LIKE MBNL1.REF NAT.STRUCT.MOL.BIOL. V. 15 1343 2008REFN ISSN 1545-9993PMID 19043415DOI 10.1038/NSMB.1519 Variant Set Distributions Mapped Variants
General Structure Information 3ctz XPNPEP1 structure of human cytosolic x-prolyl aminopeptidase 1.6Å AUTH X.LI,Z.LOU,X.LI,W.ZHOU,M.MA,Y.CAO,Y.GENG,M.BARTLAM,AUTH 2 X.C.ZHANG,Z.RAOTITL STRUCTURE OF HUMAN CYTOSOLIC X-PROLYL AMINOPEPTIDASE: ATITL 2 DOUBLE MN(II)-DEPENDENT DIMERIC ENZYME WITH A NOVELTITL 3 THREE-DOMAIN SUBUNITREF J.BIOL.CHEM. V. 283 22858 2008REFN ISSN 0021-9258PMID 18515364DOI 10.1074/JBC.M710274200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3zwf ELAC1 crystal structure of human trnase z, short form (elac1). 1.7Å AUTH C.K.ALLERSTON,T.KROJER,G.BERRIDGE,N.BURGESS-BROWN,AUTH 2 A.CHAIKUAD,R.CHALK,J.M.ELKINS,C.GILEADI,S.V.A.LATWIEL,AUTH 3 P.SAVITSKY,M.VOLLMAR,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 4 C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF HUMAN TRNASE Z, SHORT FORM (ELAC1).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vpk MYNN crystal structure of the btb domain of human myoneurin 2.0Å AUTH C.D.O.COOPER,J.W.MURRAY,A.BULLOCK,A.C.W.PIKE,AUTH 2 F.VON DELFT,P.FILIPPAKOPOULOS,E.SALAH,A.EDWARDS,AUTH 3 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,S.KNAPPTITL CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMANTITL 2 MYONEURINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2y43 RAD18 rad18 ubiquitin ligase ring domain structure 1.8Å AUTH A.HUANG,R.G.HIBBERT,R.N.DE JONG,D.DAS,T.K.SIXMA,R.BOELENSTITL SYMMETRY AND ASYMMETRY OF THE RING-RING DIMER OF RAD18.REF J.MOL.BIOL. V. 410 424 2011REFN ISSN 0022-2836PMID 21549715DOI 10.1016/J.JMB.2011.04.051 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ep0 PRDM12 methyltransferase domain of human pr domain-containing protein 12 2.1Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,J.MIN,A.N.PLOTNIKOV,H.WUTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN PR DOMAIN-CONTAINING PROTEIN 12.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3iwp CUTC crystal structure of human copper homeostasis protein cutc 2.5Å AUTH Y.LI,J.DU,P.ZHANG,J.DINGTITL CRYSTAL STRUCTURE OF HUMAN COPPER HOMEOSTASISTITL 2 PROTEIN CUTC REVEALS A POTENTIAL COPPER-BINDINGTITL 3 SITEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3d8c HIF1AN factor inhibiting hif-1 alpha d201g mutant in complex with zn(ii), alpha-ketoglutarate and hif-1 alpha 19mer 2.1Å AUTH K.S.HEWITSON,S.L.HOLMES,D.EHRISMANN,A.P.HARDY,R.CHOWDHURY,AUTH 2 C.J.SCHOFIELD,M.A.MCDONOUGHTITL EVIDENCE THAT TWO ENZYME-DERIVED HISTIDINE LIGANDS ARETITL 2 SUFFICIENT FOR IRON BINDING AND CATALYSIS BY FACTORTITL 3 INHIBITING HIF (FIH).REF J.BIOL.CHEM. V. 283 25971 2008REFN ISSN 0021-9258PMID 18611856DOI 10.1074/JBC.M804999200 Variant […]