Assessment of Structural Intolerance and Durability
General Structure Information 2css RIMS1 solution structure of the pdz domain of human kiaa0340 protein -1.0Å AUTH K.INOUE,X.-R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN OF HUMANTITL 2 KIAA0340 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kiv ANKS1B aida-1 sam domain tandem -1.0Å AUTH A.KURABI,S.BRENER,M.MOBLI,J.J.KWAN,L.W.DONALDSONTITL A NUCLEAR LOCALIZATION SIGNAL AT THE SAM-SAM DOMAINTITL 2 INTERFACE OF AIDA-1 SUGGESTS A REQUIREMENT FORTITL 3 DOMAIN UNCOUPLING PRIOR TO NUCLEAR IMPORT.REF J.MOL.BIOL. V. 392 1168 2009REFN ISSN 0022-2836PMID 19666031DOI 10.1016/J.JMB.2009.08.004 Variant Set Distributions Mapped Variants
General Structure Information 2wqz NLGN4X crystal structure of synaptic protein neuroligin-4 in complex with neurexin-beta 1: alternative refinement 3.9Å AUTH I.P.FABRICHNY,P.LEONE,G.SULZENBACHER,D.COMOLETTI,M.T.MILLER,AUTH 2 P.TAYLOR,Y.BOURNE,P.MARCHOTTITL STRUCTURAL ANALYSIS OF THE SYNAPTIC PROTEIN NEUROLIGIN ANDTITL 2 ITS BETA-NEUREXIN COMPLEX: DETERMINANTS FOR FOLDING ANDTITL 3 CELL ADHESION.REF NEURON V. 56 979 2007REFN ISSN 0896-6273PMID 18093521DOI 10.1016/J.NEURON.2007.11.013 Variant Set Distributions Ripley’s […]
General Structure Information 3cyn GPX8 the structure of human gpx8 2.0Å AUTH K.L.KAVANAGH,C.JOHANSSON,W.W.YUE,G.KOCHAN,U.OPPERMANNTITL THE STRUCTURE OF HUMAN GPX8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3gcw PCSK9 pcsk9:egfa(h306y) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3icu RNF128 protease-associated domain of the e3 ligase grail 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,A.SEITOVA,J.WEIGELT,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL PA DOMAIN OF THE E3 LIGASE GRAILREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dgc IL22RA1 structure of il-22/il-22r1 2.5Å AUTH B.C.JONES,N.J.LOGSDON,M.R.WALTERTITL STRUCTURE OF IL-22 BOUND TO ITS HIGH-AFFINITY IL-22R1 CHAIN.REF STRUCTURE V. 16 1333 2008REFN ISSN 0969-2126PMID 18599299DOI 10.1016/J.STR.2008.06.005 Variant Set Distributions Mapped Variants
General Structure Information 3eu9 ZDHHC17 the ankyrin repeat domain of huntingtin interacting protein 14 1.99Å AUTH T.GAO,R.E.COLLINS,J.R.HORTON,X.ZHANG,R.ZHANG,A.DHAYALAN,AUTH 2 R.TAMAS,A.JELTSCH,X.CHENGTITL THE ANKYRIN REPEAT DOMAIN OF HUNTINGTIN INTERACTING PROTEINTITL 2 14 CONTAINS A SURFACE AROMATIC CAGE, A POTENTIAL SITE FORTITL 3 METHYL-LYSINE BINDING.REF PROTEINS V. 76 772 2009REFN ISSN 0887-3585PMID 19434754DOI 10.1002/PROT.22452 Variant Set Distributions Mapped Variants
General Structure Information 3gcx PCSK9 pcsk9:egfa (ph 7.4) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Mapped Variants
General Structure Information 3ixe LIMS2 structural basis of competition between pinch1 and pinch2 for binding to the ankyrin repeat domain of integrin-linked kinase 1.9Å AUTH B.P.CHISWELL,A.L.STIEGLER,Z.RAZINIA,E.NALIBOTSKI,AUTH 2 T.J.BOGGON,D.A.CALDERWOODTITL STRUCTURAL BASIS OF COMPETITION BETWEEN PINCH1 ANDTITL 2 PINCH2 FOR BINDING TO THE ANKYRIN REPEAT DOMAIN OFTITL 3 INTEGRIN-LINKED KINASE.REF J.STRUCT.BIOL. V. 170 157 2010REFN ISSN 1047-8477PMID […]