Assessment of Structural Intolerance and Durability
General Structure Information 3fdw SYTL4 crystal structure of a c2 domain from human synaptotagmin- like protein 4 2.2Å AUTH J.B.BONANNO,M.RUTTER,K.T.BAIN,S.MILLER,R.ROMERO,AUTH 2 S.WASSERMAN,J.M.SAUDER,S.K.BURLEY,S.C.ALMOTITL CRYSTAL STRUCTURE OF A C2 DOMAIN FROM HUMANTITL 2 SYNAPTOTAGMIN-LIKE PROTEIN 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4bx9 VPS33A human vps33a in complex with a fragment of human vps16 2.6Å AUTH S.C.GRAHAM,L.WARTOSCH,S.R.GRAY,E.J.SCOURFIELD,J.E.DEANE,AUTH 2 J.P.LUZIO,D.J.OWENTITL STRUCTURAL BASIS OF VPS33A RECRUITMENT TO THE HUMAN HOPSTITL 2 COMPLEX BY VPS16.REF PROC.NATL.ACAD.SCI.USA V. 110 13345 2013REFN ISSN 0027-8424PMID 23901104DOI 10.1073/PNAS.1307074110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2ymb MITD1 structures of mitd1 3.4Å AUTH M.A.HADDERS,M.AGROMAYOR,T.OBITA,O.PERISIC,A.CABALLE,M.KLOC,AUTH 2 M.H.LAMERS,R.L.WILLIAMS,J.MARTIN-SERRANOTITL ESCRT-III BINDING PROTEIN MITD1 IS INVOLVED IN CYTOKINESISTITL 2 AND HAS AN UNANTICIPATED PLD FOLD THAT BINDS MEMBRANES.REF PROC.NATL.ACAD.SCI.USA V. 109 17424 2012REFN ISSN 0027-8424PMID 23045692DOI 10.1073/PNAS.1206839109 Variant Set Distributions Mapped Variants
General Structure Information 3ff7 KLRG1 structure of nk cell receptor klrg1 bound to e-cadherin 1.8Å AUTH Y.LI,M.HOFMANN,Q.WANG,L.TENG,L.K.CHLEWICKI,AUTH 2 H.PIRCHER,R.A.MARIUZZATITL STRUCTURE OF NATURAL KILLER CELL RECEPTOR KLRG1TITL 2 BOUND TO E-CADHERIN REVEALS BASIS FORTITL 3 MHC-INDEPENDENT MISSING SELF RECOGNITION.REF IMMUNITY V. 31 35 2009REFN ISSN 1074-7613PMID 19604491DOI 10.1016/J.IMMUNI.2009.04.019 Variant Set Distributions Mapped Variants
General Structure Information 2v90 PDZD3 crystal structure of the 3rd pdz domain of intestine- and kidney-enriched pdz domain ikepp (pdzd3) 2.0Å AUTH J.UPPENBERG,C.GILEADI,C.PHILLIPS,J.ELKINS,G.BUNKOCZI,AUTH 2 C.COOPER,A.C.W.PIKE,E.SALAH,E.UGOCHUKWU,C.H.ARROWSMITH,AUTH 3 A.EDWARDS,M.SUNDSTROM,J.WEIGELT,D.A.DOYLETITL CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF INTESTINE- ANDTITL 2 KIDNEY-ENRICHED PDZ DOMAIN IKEPP ( PDZD3)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2nms CD300LF the crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells irem-1 2.6Å AUTH J.A.MARQUEZ,E.GALFRE,F.DUPEUX,D.FLOT,O.MORAN,AUTH 2 N.DIMASITITL THE CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAINTITL 2 OF THE INHIBITOR RECEPTOR EXPRESSED ON MYELOIDTITL 3 CELLS IREM-1.REF J.MOL.BIOL. V. 367 310 2007REFN ISSN 0022-2836PMID 17275839DOI 10.1016/J.JMB.2007.01.011 Variant Set […]
General Structure Information 4gll UXS1 crystal structure of human udp-xylose synthase. 2.5Å AUTH S.J.POLIZZI,R.M.WALSH,W.B.PEEPLES,J.M.LIM,L.WELLS,Z.A.WOODTITL HUMAN UDP-ALPHA-D-XYLOSE SYNTHASE AND ESCHERICHIA COLI ARNATITL 2 CONSERVE A CONFORMATIONAL SHUNT THAT CONTROLS WHETHER XYLOSETITL 3 OR 4-KETO-XYLOSE IS PRODUCED.REF BIOCHEMISTRY V. 51 8844 2012REFN ISSN 0006-2960PMID 23072385DOI 10.1021/BI301135B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3og4 IFNLR1 the crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group p21212 2.16Å AUTH Z.J.MIKNIS,E.MAGRACHEVA,W.LI,A.ZDANOV,S.V.KOTENKO,A.WLODAWERTITL CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN INTERFERON-LAMBDA1TITL 2 WITH ITS HIGH AFFINITY RECEPTOR INTERFERON-LAMBDAR1.REF J.MOL.BIOL. V. 404 650 2010REFN ISSN 0022-2836PMID 20934432DOI 10.1016/J.JMB.2010.09.068 Variant Set Distributions Ripley’s K […]
General Structure Information 3bd9 HS3ST5 human 3-o-sulfotransferase isoform 5 with bound pap 2.3Å AUTH D.XU,A.F.MOON,D.SONG,L.C.PEDERSEN,J.LIUTITL ENGINEERING SULFOTRANSFERASES TO MODIFY HEPARANTITL 2 SULFATE.REF NAT.CHEM.BIOL. V. 4 200 2008REFN ISSN 1552-4450PMID 18223645DOI 10.1038/NCHEMBIO.66 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1wfv MAGI2 solution structure of the fifth pdz domain of human membrane associated guanylate kinase inverted-2 (kiaa0705 protein) -1.0Å AUTH N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH PDZ DOMAIN OFTITL 2 HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASETITL 3 INVERTED-2 (KIAA0705 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants