Assessment of Structural Intolerance and Durability
General Structure Information 3cbq REM2 crystal structure of the human rem2 gtpase with bound gdp 1.82Å AUTH L.NEDYALKOVA,Y.SHEN,Y.TONG,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN REM2 GTPASE WITHTITL 2 BOUND GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kom PARD3 solution structure of humar par-3b pdz2 (residues 451-549) -1.0Å AUTH D.R.JENSEN,C.WOYTOVICH,M.LI,P.DUVNJAK,M.S.CASSIDY,AUTH 2 R.O.FREDERICK,L.F.BERGEMAN,F.C.PETERSON,B.F.VOLKMANTITL RAPID, ROBOTIC, SMALL-SCALE PROTEIN PRODUCTION FORTITL 2 NMR SCREENING AND STRUCTURE DETERMINATION.REF PROTEIN SCI. V. 19 570 2010REFN ISSN 0961-8368PMID 20073081DOI 10.1002/PRO.335 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dnx STX12 solution structure of rsgi ruh-063, an n-terminal domain of syntaxin 12 from human cdna -1.0Å AUTH T.ABE,H.HIROTA,Y.MUTO,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-063, AN N-TERMINALTITL 2 DOMAIN OF SYNTAXIN 12 FROM HUMAN CDNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2l73 NOXO1 structure of the noxo1b px domain -1.0Å AUTH N.Y.DAVIS,L.C.MCPHAIL,D.A.HORITATITL STRUCTURE OF THE NOXO1B PX DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4emu TMEM173 crystal structure of ligand free human sting 1.9Å AUTH C.SHU,G.YI,T.WATTS,C.C.KAO,P.LITITL STRUCTURE OF STING BOUND TO CYCLIC DI-GMP REVEALS THETITL 2 MECHANISM OF CYCLIC DINUCLEOTIDE RECOGNITION BY THE IMMUNETITL 3 SYSTEM.REF NAT.STRUCT.MOL.BIOL. V. 19 722 2012REFN ISSN 1545-9993PMID 22728658DOI 10.1038/NSMB.2331 Variant Set Distributions Mapped Variants
General Structure Information 3a4u MCFD2 crystal structure of mcfd2 in complex with carbohydrate recognition domain of ergic-53 1.84Å AUTH M.NISHIO,Y.KAMIYA,T.MIZUSHIMA,S.WAKATSUKI,H.SASAKAWA,AUTH 2 K.YAMAMOTO,S.UCHIYAMA,M.NODA,A.R.MCKAY,K.FUKUI,H.P.HAURI,AUTH 3 K.KATOTITL STRUCTURAL BASIS FOR THE COOPERATIVE INTERPLAY BETWEEN THETITL 2 TWO CAUSATIVE GENE PRODUCTS OF COMBINED FACTOR V AND FACTORTITL 3 VIII DEFICIENCY.REF PROC.NATL.ACAD.SCI.USA V. 107 4034 2010REFN ISSN 0027-8424PMID 20142513DOI 10.1073/PNAS.0908526107 […]
General Structure Information 3bbp GCC2 rab6-gtp:gcc185 rab binding domain complex 3.0Å AUTH A.S.BURGUETE,T.D.FENN,A.T.BRUNGER,S.R.PFEFFERTITL RAB AND ARL GTPASE FAMILY MEMBERS COOPERATE IN THETITL 2 LOCALIZATION OF THE GOLGIN GCC185.REF CELL(CAMBRIDGE,MASS.) V. 132 286 2008REFN ISSN 0092-8674PMID 18243103DOI 10.1016/J.CELL.2007.11.048 Variant Set Distributions Mapped Variants
General Structure Information 2v62 VRK2 structure of vaccinia-related kinase 2 1.7Å AUTH E.D.SCHEEFF,J.ESWARAN,G.BUNKOCZI,S.KNAPP,G.MANNINGTITL STRUCTURE OF THE PSEUDOKINASE VRK3 REVEALS A DEGRADEDTITL 2 CATALYTIC SITE, A HIGHLY CONSERVED KINASE FOLD, AND ATITL 3 PUTATIVE REGULATORY BINDING SITE.REF STRUCTURE V. 17 128 2009REFN ISSN 0969-2126PMID 19141289DOI 10.1016/J.STR.2008.10.018 Variant Set Distributions Mapped Variants
General Structure Information 2rgn ARHGEF25 crystal structure of p63rhogef complex with galpha-q and rhoa 3.5Å AUTH S.LUTZ,A.SHANKARANARAYANAN,C.COCO,M.RIDILLA,M.R.NANCE,AUTH 2 C.VETTEL,D.BALTUS,C.R.EVELYN,R.R.NEUBIG,T.WIELAND,J.J.TESMERTITL STRUCTURE OF GALPHAQ-P63RHOGEF-RHOA COMPLEX REVEALS ATITL 2 PATHWAY FOR THE ACTIVATION OF RHOA BY GPCRS.REF SCIENCE V. 318 1923 2007REFN ISSN 0036-8075PMID 18096806DOI 10.1126/SCIENCE.1147554 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3um1 BROX crystal structure of the brox bro1 domain in complex with the c- terminal tail of chmp5 2.71Å AUTH R.MU,V.DUSSUPT,J.JIANG,P.SETTE,V.RUDD,W.CHUENCHOR,N.F.BELLO,AUTH 2 F.BOUAMR,T.S.XIAOTITL TWO DISTINCT BINDING MODES DEFINE THE INTERACTION OF BROXTITL 2 WITH THE C-TERMINAL TAILS OF CHMP5 AND CHMP4B.REF STRUCTURE V. 20 887 2012REFN ISSN 0969-2126PMID 22484091DOI 10.1016/J.STR.2012.03.001 Variant Set […]