Assessment of Structural Intolerance and Durability
General Structure Information 1znc CA4 human carbonic anhydrase iv 2.8Å AUTH T.STAMS,S.K.NAIR,T.OKUYAMA,A.WAHEED,W.S.SLY,AUTH 2 D.W.CHRISTIANSONTITL CRYSTAL STRUCTURE OF THE SECRETORY FORM OFTITL 2 MEMBRANE-ASSOCIATED HUMAN CARBONIC ANHYDRASE IV ATTITL 3 2.8-A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 93 13589 1996REFN ISSN 0027-8424PMID 8942978DOI 10.1073/PNAS.93.24.13589 Variant Set Distributions Mapped Variants
General Structure Information 2oo0 ODC1 a structural insight into the inhibition of human and leishmania donovani ornithine decarboxylases by 3-aminooxy-1-aminopropane 1.9Å AUTH V.T.DUFE,D.INGNER,O.HEBY,A.R.KHOMUTOV,L.PERSSON,AUTH 2 S.AL-KARADAGHITITL A STRUCTURAL INSIGHT INTO THE INHIBITION OF HUMAN ANDTITL 2 LEISHMANIA DONOVANI ORNITHINE DECARBOXYLASES BYTITL 3 1-AMINO-OXY-3-AMINOPROPANE.REF BIOCHEM.J. V. 405 261 2007REFN ISSN 0264-6021PMID 17407445DOI 10.1042/BJ20070188 Variant Set Distributions Ripley’s […]
General Structure Information 2xsx ENO3 crystal structure of human beta enolase enob 1.7Å AUTH M.VOLLMAR,E.KRYSZTOFINSKA,A.CHAIKUAD,T.KROJER,R.COCKING,AUTH 2 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 W.W.YUE,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA ENOLASE ENOBREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4e1o HDC human histidine decarboxylase complex with histidine methyl ester (hme) 1.8Å AUTH H.KOMORI,Y.NITTA,H.UENO,Y.HIGUCHITITL STRUCTURAL STUDY REVEALS THAT SER-354 DETERMINES SUBSTRATETITL 2 SPECIFICITY ON HUMAN HISTIDINE DECARBOXYLASEREF J.BIOL.CHEM. V. 287 29175 2012REFN ISSN 0021-9258PMID 22767596DOI 10.1074/JBC.M112.381897 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4h27 SDS modulating the function of human serine racemase and human serine dehydratase by protein engineering 1.3Å AUTH C.Y.WANG,S.C.KU,C.C.LEE,A.H.WANGTITL MODULATING THE FUNCTION OF HUMAN SERINE RACEMASE AND HUMANTITL 2 SERINE DEHYDRATASE BY PROTEIN ENGINEERING.REF PROTEIN ENG.DES.SEL. V. 25 741 2012REFN ISSN 1741-0126PMID 23112234DOI 10.1093/PROTEIN/GZS078 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1pv8 ALAD crystal structure of a low activity f12l mutant of human porphobilinogen synthase 2.2Å AUTH S.BREINIG,J.KERVINEN,L.STITH,A.S.WASSON,R.FAIRMAN,AUTH 2 A.WLODAWER,A.ZDANOV,E.K.JAFFETITL CONTROL OF TETRAPYRROLE BIOSYNTHESIS BY ALTERNATE QUATERNARYTITL 2 FORMS OF PORPHOBILINOGEN SYNTHASE.REF NAT.STRUCT.BIOL. V. 10 757 2003REFN ISSN 1072-8368PMID 12897770DOI 10.1038/NSB963 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1msv AMD1 the s68a s-adenosylmethionine decarboxylase proenzyme processing mutant. 1.75Å AUTH W.D.TOLBERT,Y.ZHANG,S.E.COTTET,E.M.BENNETT,AUTH 2 J.L.EKSTROM,A.E.PEGG,S.E.EALICKTITL MECHANISM OF HUMAN S-ADENOSYLMETHIONINETITL 2 DECARBOXYLASE PROENZYME PROCESSING AS REVEALED BYTITL 3 THE STRUCTURE OF THE S68A MUTANT.REF BIOCHEMISTRY V. 42 2386 2003REFN ISSN 0006-2960PMID 12600205DOI 10.1021/BI0268854 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3uyq CA3 hca 3 1.7Å AUTH I.ELDER,Z.FISHER,P.J.LAIPIS,C.TU,R.MCKENNA,D.N.SILVERMANTITL STRUCTURAL AND KINETIC ANALYSIS OF PROTON SHUTTLE RESIDUESTITL 2 IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE III.REF PROTEINS V. 68 337 2007REFN ISSN 0887-3585PMID 17427958DOI 10.1002/PROT.21403 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3gw3 UROD human urod mutant k297n 1.7Å AUTH C.A.WARBY,J.D.PHILLIPS,H.A.BERGONIA,F.G.WHITBY,C.P.HILL,AUTH 2 J.P.KUSHNERTITL STRUCTURAL AND KINETIC CHARACTERIZATION OF MUTANT HUMANTITL 2 UROPORPHYRINOGEN DECARBOXYLASES.REF CELL MOL BIOL V. 55 40 2009REF 2 (NOISY-LE-GRAND)REFNPMID 19656450 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ewu UMPS d312n mutant of human orotidyl-5-monophosphate decarboxylase in complex with 6-acetyl-ump, covalent adduct 1.6Å AUTH D.HEINRICH,U.DIEDERICHSEN,M.G.RUDOLPHTITL LYS314 IS A NUCLEOPHILE IN NON-CLASSICAL REACTIONS OFTITL 2 OROTIDINE-5-MONOPHOSPHATE DECARBOXYLASEREF CHEMISTRY V. 15 6619 2009REFN ISSN 0947-6539PMID 19472232DOI 10.1002/CHEM.200900397 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants