1ZNC.B | CA4 – ASTRID

1ZNC.B | CA4

General Structure Information

PDB ID	1znc
HGNC Gene Label(s)	CA4
Structure Name	human carbonic anhydrase iv
Resolution	2.8Å
Reference	AUTH T.STAMS,S.K.NAIR,T.OKUYAMA,A.WAHEED,W.S.SLY,AUTH 2 D.W.CHRISTIANSONTITL CRYSTAL STRUCTURE OF THE SECRETORY FORM OFTITL 2 MEMBRANE-ASSOCIATED HUMAN CARBONIC ANHYDRASE IV ATTITL 3 2.8-A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 93 13589 1996REFN ISSN 0027-8424PMID 8942978DOI 10.1073/PNAS.93.24.13589

Variant Set Distributions

ExAC Variants

Number Of Residues	233
Number Of SNVs	74
Number Of Permutations	27306
Optimal Distance Threshold	9.0
K Statistic	0.061
p-value	0.399

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
17:58232689		Y>H	B:7	(20.38, -18.17, 27.18)
17:58232690	rs556598729	Y>C	B:7	(20.38, -18.17, 27.18)
17:58233930		K>R	B:15	(28.28, -10.18, 32.29)
17:58233936	rs563335203	G>V	B:20	(28.15, -8.38, 23.64)
17:58233948		Q>R	B:24	(24.94, -3.61, 26.06)
17:58233953		D>N	B:26	(19.77, 2.28, 23.58)
17:58233957	COSM4068354	R>H	B:27	(16.53, 0.51, 18.18)
17:58233969		I>N	B:31	(9.72, -5.32, 25.53)
17:58233970		I>M	B:31	(9.72, -5.32, 25.53)
17:58233983		T>A	B:36	(-2.98, 0.35, 28.39)
17:58234002		K>T	B:42	(-7.63, 3.77, 11.12)
17:58234017	rs202023904	F>C	B:47	(-0.08, -9.53, 8.49)
17:58234034	COSM3520333	D>N	B:52	(-0.60, -23.01, 2.81)
17:58234043	rs531909330	Q>K	B:55	(6.90, -28.77, 3.19)
17:58234047		T>M	B:56	(9.69, -31.70, 4.24)
17:58234061		N>Y	B:61	(19.85, -29.03, 19.00)
17:58234062		N>T	B:61	(19.85, -29.03, 19.00)
17:58234067		G>R	B:63	(22.05, -25.38, 21.34)
17:58234809	rs370036524	K>T	B:76	(11.20, -23.62, 1.14)
17:58234844		Y>H	B:88	(9.76, -8.33, 5.11)
17:58234853		K>E	B:91	(15.66, -16.54, 5.38)
17:58234860	rs201915875	L>S	B:93	(11.19, -21.29, 13.24)
17:58234868		H>Y	B:96	(12.67, -18.87, 23.08)
17:58234872	COSM3958614	W>S	B:97	(12.10, -23.96, 25.72)
17:58234877	rs373844529 COSM279506	D>N	B:99	(9.77, -25.78, 33.40)
17:58234893		G>A	B:104	(8.52, -18.62, 29.19)
17:58234896		S>L	B:105	(7.85, -15.48, 27.83)
17:58234898	rs376816367	E>K	B:106	(11.61, -13.51, 25.39)
17:58234901		H>Y	B:107	(8.46, -10.22, 24.12)
17:58234906		S>R	B:108	(5.72, -8.95, 28.65)
17:58234929		M>T	B:116	(6.22, -21.32, 24.99)
17:58234930		M>I	B:116	(6.22, -21.32, 24.99)
17:58235051	rs185658468	M>L	B:118	(6.87, -18.72, 18.12)
17:58235057		I>L	B:120	(8.53, -16.46, 12.69)
17:58235058		I>T	B:120	(8.53, -16.46, 12.69)
17:58235064		H>P	B:122	(10.13, -13.30, 8.42)
17:58235111		P>S	B:123	(15.21, -11.13, 5.36)
17:58235116		E>D	B:138	(16.39, 0.33, 10.01)
17:58235118		D>A	B:139	(13.10, -2.02, 8.62)
17:58235120	rs573405938	E>K	B:140	(16.50, -5.63, 7.55)
17:58235439	rs185942554	N>K	B:154	(-1.97, -28.40, 19.17)
17:58235442	rs149925430	E>D	B:155	(-2.93, -32.63, 16.41)
17:58235461		E>Q	B:162	(7.05, -36.49, 17.27)
17:58235463		E>D	B:162	(7.05, -36.49, 17.27)
17:58235478	rs372013244	I>M	B:167	(17.32, -33.38, 18.02)
17:58235483	rs147624521	K>R	B:169	(22.81, -35.52, 21.83)
17:58235647		M>T	B:172	(21.81, -33.23, 16.49)
17:58235649		S>R	B:173	(20.02, -32.51, 12.67)
17:58235656		T>M	B:175	(13.69, -34.53, 8.53)
17:58235658		M>V	B:176	(9.75, -32.25, 10.36)
17:58235659	rs375031809	M>T	B:176	(9.75, -32.25, 10.36)
17:58235662		A>V	B:177	(7.04, -34.47, 9.44)
17:58235674		L>P	B:181	(4.21, -22.91, 8.37)
17:58235678	rs142186287	L>F	B:182	(-0.86, -22.38, 8.41)
17:58235715		F>L	B:192	(0.72, -5.53, 20.31)
17:58235718	rs121434551 CM057973	R>C	B:193	(4.15, -3.47, 14.20)
17:58235719		R>H	B:193	(4.15, -3.47, 14.20)
17:58235725		L>R	B:195	(11.17, -0.58, 16.13)
17:58235736		T>A	B:199	(16.72, -12.15, 21.35)
17:58235743		P>L	B:201	(24.16, -12.54, 20.35)
17:58235749		C>Y	B:203	(21.90, -8.17, 19.49)
17:58235750		C>W	B:203	(21.90, -8.17, 19.49)
17:58235751		D>N	B:204	(21.89, -6.82, 15.58)
17:58235759		K>N	B:206	(19.29, -5.92, 11.60)
17:58235763	rs117704637	V>I	B:208	(10.26, -5.23, 12.63)
17:58235768		W>C	B:209	(10.45, -7.68, 17.40)
17:58235772	rs2229178	V>L	B:211	(3.43, -9.13, 19.29)
17:58235776		F>Y	B:212	(0.52, -11.68, 16.78)
17:58235779	rs76995634	R>Q	B:213	(-5.19, -9.61, 21.59)
17:58235787		I>V	B:216	(-0.38, -20.38, 20.52)
17:58235788		I>T	B:216	(-0.38, -20.38, 20.52)
17:58236607	rs150432787	Q>P	B:227	(10.94, -33.68, 28.99)
17:58236607	rs150432787	Q>P	B:227	(11.74, -29.29, 28.69)
17:58236616		Y>C	B:230	(19.15, -33.05, 26.87)
17:58236621		D>N	B:232	(24.75, -30.93, 27.51)
17:58236627		E>K	B:236	(27.69, -34.14, 28.16)
17:58236630		Q>E	B:237	(22.47, -35.95, 27.38)
17:58236634		T>I	B:238	(23.90, -33.19, 31.84)
17:58236636		V>M	B:239	(21.94, -29.87, 31.02)
17:58236639	COSM116283	S>C	B:240	(17.76, -29.93, 30.66)
17:58236646	rs187221698	K>R	B:242	(15.22, -25.38, 31.86)
17:58236660		P>S	B:247	(16.68, -10.53, 30.15)
17:58236673		L>P	B:251	(10.74, 1.06, 26.16)
17:58236681		R>C	B:254	(12.10, 1.26, 22.41)
17:58236685	rs377145857	T>M	B:255	(6.50, 4.30, 20.96)