Assessment of Structural Intolerance and Durability
General Structure Information 4gba DCUN1D3 dcnl complex with n-terminally acetylated nedd8 e2 peptide 2.4Å AUTH J.K.MONDA,D.C.SCOTT,D.J.MILLER,J.LYDEARD,D.KING,J.W.HARPER,AUTH 2 E.J.BENNETT,B.A.SCHULMANTITL STRUCTURAL CONSERVATION OF DISTINCTIVE N-TERMINALTITL 2 ACETYLATION-DEPENDENT INTERACTIONS ACROSS A FAMILY OFTITL 3 MAMMALIAN NEDD8 LIGATION ENZYMES.REF STRUCTURE V. 21 42 2013REFN ISSN 0969-2126PMID 23201271DOI 10.1016/J.STR.2012.10.013 Variant Set Distributions Mapped Variants
General Structure Information 3g1n HUWE1 catalytic domain of the human e3 ubiquitin-protein ligase huwe1 2.6Å AUTH J.R.WALKER,L.QIU,Y.LI,T.DAVIS,W.TEMPEL,J.WEIGELT,AUTH 2 C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,A.BOTCHKAREV,AUTH 3 S.DHE-PAGANONTITL HECT DOMAIN OF HUMAN HUWE1/MULEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hpl BCOR pcgf1 ub fold (rawul)/bcor pufd complex 2.0Å AUTH S.E.JUNCO,R.WANG,J.C.GAIPA,A.B.TAYLOR,V.SCHIRF,M.D.GEARHART,AUTH 2 V.J.BARDWELL,B.DEMELER,P.J.HART,C.A.KIMTITL STRUCTURE OF THE POLYCOMB GROUP PROTEIN PCGF1 IN COMPLEXTITL 2 WITH BCOR REVEALS BASIS FOR BINDING SELECTIVITY OF PCGFTITL 3 HOMOLOGS.REF STRUCTURE V. 21 665 2013REFN ISSN 0969-2126PMID 23523425DOI 10.1016/J.STR.2013.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4gao DCUN1D2 dcnl complex with n-terminally acetylated nedd8 e2 peptide 3.28Å AUTH J.K.MONDA,D.C.SCOTT,D.J.MILLER,J.LYDEARD,D.KING,J.W.HARPER,AUTH 2 E.J.BENNETT,B.A.SCHULMANTITL STRUCTURAL CONSERVATION OF DISTINCTIVE N-TERMINALTITL 2 ACETYLATION-DEPENDENT INTERACTIONS ACROSS A FAMILY OFTITL 3 MAMMALIAN NEDD8 LIGATION ENZYMES.REF STRUCTURE V. 21 42 2013REFN ISSN 0969-2126PMID 23201271DOI 10.1016/J.STR.2012.10.013 Variant Set Distributions Mapped Variants
General Structure Information 1zdn UBE2S ubiquitin-conjugating enzyme e2s 1.93Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 4hpm BCORL1 pcgf1 ub fold (rawul)/bcorl1 pufd complex 1.85Å AUTH S.E.JUNCO,R.WANG,J.C.GAIPA,A.B.TAYLOR,V.SCHIRF,M.D.GEARHART,AUTH 2 V.J.BARDWELL,B.DEMELER,P.J.HART,C.A.KIMTITL STRUCTURE OF THE POLYCOMB GROUP PROTEIN PCGF1 IN COMPLEXTITL 2 WITH BCOR REVEALS BASIS FOR BINDING SELECTIVITY OF PCGFTITL 3 HOMOLOGS.REF STRUCTURE V. 21 665 2013REFN ISSN 0969-2126PMID 23523425DOI 10.1016/J.STR.2013.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4orh UBE2V2 crystal structure of rnf8 bound to the ubc13/mms2 heterodimer 4.8Å AUTH S.J.CAMPBELL,R.A.EDWARDS,C.C.LEUNG,D.NECULAI,C.D.HODGE,AUTH 2 S.DHE-PAGANON,J.N.GLOVERTITL MOLECULAR INSIGHTS INTO THE FUNCTION OF RING FINGERTITL 2 (RNF)-CONTAINING PROTEINS HRNF8 AND HRNF168 INTITL 3 UBC13/MMS2-DEPENDENT UBIQUITYLATION.REF J.BIOL.CHEM. V. 287 23900 2012REFN ISSN 0021-9258PMID 22589545DOI 10.1074/JBC.M112.359653 Variant Set Distributions Mapped Variants
General Structure Information 4ah6 DARS2 human mitochondrial aspartyl-trna synthetase 3.7Å AUTH E.ENNIFAR,C.FLORENTZ,A.GAUDRY,B.LORBER,A.NEUENFELDT,AUTH 2 C.SAUTER,M.SISSLERTITL THERMODYNAMIC PROPERTIES DISTINGUISH HUMAN MITOCHONDRIALTITL 2 ASPARTYL-TRNA SYNTHETASE FROM BACTERIAL HOMOLOG WITH SAMETITL 3 3D ARCHITECTUREREF NUCLEIC ACIDS RES. V. 41 2698 2013REFN ISSN 0305-1048PMID 23275545DOI 10.1093/NAR/GKS1322 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3l4h HECW1 helical box domain and second ww domain of the human e3 ubiquitin- protein ligase hecw1 1.8Å AUTH J.R.WALKER,L.QIU,Y.LI,J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL THE TANDEM HELICAL BOX AND SECOND WW DOMAINS OF HUMAN HECW1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yrv UBE2U novel ubiquitin-conjugating enzyme 2.18Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants