Assessment of Structural Intolerance and Durability
General Structure Information 2yre FBXO30 solution structure of the zinc finger domains (1-87) from human f-box only protein -1.0Å AUTH T.NAGASHIMA,T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZINC FINGER DOMAINSTITL 2 (1-87) FROM HUMAN F-BOX ONLY PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3icu RNF128 protease-associated domain of the e3 ligase grail 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,A.SEITOVA,J.WEIGELT,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL PA DOMAIN OF THE E3 LIGASE GRAILREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3pg6 DTX3L the carboxyl terminal domain of human deltex 3-like 1.7Å AUTH J.OBIERO,J.R.WALKER,S.DHE-PAGANONTITL FOLD OF THE CONSERVED DTC DOMAIN IN DELTEX PROTEINS.REF PROTEINS V. 80 1495 2012REFN ISSN 0887-3585PMID 22411408DOI 10.1002/PROT.24054 Variant Set Distributions Mapped Variants
General Structure Information 3b76 LNX1 crystal structure of the third pdz domain of human ligand-of-numb protein-x (lnx1) in complex with the c-terminal peptide from the coxsackievirus and adenovirus receptor 1.75Å AUTH E.UGOCHUKWU,N.BURGESS-BROWN,G.BERRIDGE,J.ELKINS,G.BUNKOCZI,AUTH 2 A.C.W.PIKE,M.SUNDSTROM,C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,AUTH 3 O.GILEADI,F.VON DELFT,D.DOYLETITL CRYSTAL STRUCTURE OF THE THIRD PDZ DOMAIN OF HUMANTITL 2 LIGAND-OF-NUMB PROTEIN-X (LNX1) IN COMPLEX WITH THETITL 3 […]
General Structure Information 3l11 RNF168 crystal structure of the ring domain of rnf168 2.12Å AUTH S.J.CAMPBELL,R.A.EDWARDS,C.C.LEUNG,D.NECULAI,C.D.HODGE,AUTH 2 S.DHE-PAGANON,J.N.GLOVERTITL MOLECULAR INSIGHTS INTO THE FUNCTION OF RING FINGERTITL 2 (RNF)-CONTAINING PROTEINS HRNF8 AND HRNF168 INTITL 3 UBC13/MMS2-DEPENDENT UBIQUITYLATION.REF J.BIOL.CHEM. V. 287 23900 2012REFN ISSN 0021-9258PMID 22589545DOI 10.1074/JBC.M112.359653 Variant Set Distributions Mapped Variants
General Structure Information 2l0b PJA1 solution nmr structure of zinc finger domain of e3 ubiquitin-protein ligase praja-1 from homo sapiens, northeast structural genomics consortium (nesg) target hr4710b -1.0Å AUTH G.LIU,S.TONG,R.XIAO,T.B.ACTON,J.K.EVERETT,G.T.MONTELIONETITL SOLUTION STRUCTURE OF ZINC FINGER DOMAIN OF E3TITL 2 UBIQUITIN-PROTEIN LIGASE PROTEIN PRAJA-1 FROM HOMO SAPIENS,TITL 3 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGETTITL 4 HR4710BREF […]
General Structure Information 3ztg RBBP6 solution structure of the ring finger-like domain of retinoblastoma binding protein-6 (rbbp6) -1.0Å AUTH M.A.KAPPO,E.AB,F.HASSEM,R.A.ATKINSON,A.FARO,V.MULEYA,AUTH 2 T.MULAUDZI,J.O.POOLE,J.M.MCKENZIE,M.CHIBI,J.C.MOOLMAN-SMOOK,AUTH 3 D.J.G.REES,D.J.R.PUGHTITL SOLUTION STRUCTURE OF THE RING FINGER-LIKE DOMAIN OFTITL 2 RETINOBLASTOMA BINDING PROTEIN-6 (RBBP6) SUGGESTS ITTITL 3 FUNCTIONS AS A U-BOXREF J.BIOL.CHEM. V. 287 7146 2012REFN ISSN 0021-9258PMID 22130672DOI 10.1074/JBC.M110.217059 Variant Set […]
General Structure Information 1u6g CAND1 crystal structure of the cand1-cul1-roc1 complex 3.1Å AUTH S.J.GOLDENBERG,T.C.CASCIO,S.D.SHUMWAY,K.C.GARBUTT,AUTH 2 J.LIU,Y.XIONG,N.ZHENGTITL STRUCTURE OF THE CAND1-CUL1-ROC1 COMPLEX REVEALSTITL 2 REGULATORY MECHANISMS FOR THE ASSEMBLY OF THETITL 3 MULTISUBUNIT CULLIN-DEPENDENT UBIQUITIN LIGASESREF CELL(CAMBRIDGE,MASS.) V. 119 517 2004REFN ISSN 0092-8674PMID 15537541DOI 10.1016/J.CELL.2004.10.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2nvu UBA3 structure of appbp1-uba3~nedd8-nedd8-mgatp-ubc12(c111a), a trapped ubiquitin-like protein activation complex 2.8Å AUTH D.T.HUANG,H.W.HUNT,M.ZHUANG,M.D.OHI,J.M.HOLTON,AUTH 2 B.A.SCHULMANTITL BASIS FOR A UBIQUITIN-LIKE PROTEIN THIOESTERTITL 2 SWITCH TOGGLING E1-E2 AFFINITY.REF NATURE V. 445 394 2007REFN ISSN 0028-0836PMID 17220875DOI 10.1038/NATURE05490 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f4w UBE2J2 human ubiquitin-conjugating enzyme e2 j2 2.0Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants