Assessment of Structural Intolerance and Durability
General Structure Information 1jm7 BARD1 solution structure of the brca1/bard1 ring-domain heterodimer -1.0Å AUTH P.S.BRZOVIC,P.RAJAGOPAL,D.W.HOYT,M.C.KING,AUTH 2 R.E.KLEVITTITL STRUCTURE OF A BRCA1-BARD1 HETERODIMERIC RING-RINGTITL 2 COMPLEX.REF NAT.STRUCT.BIOL. V. 8 833 2001REFN ISSN 1072-8368PMID 11573085DOI 10.1038/NSB1001-833 Variant Set Distributions Mapped Variants
General Structure Information 4juy RNF31 crystal structure of the pub domain of e3 ubiquitin ligase rnf31 2.4Å AUTH J.HU,A.DONG,Y.LI,A.WERNIMONT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,Y.TONGTITL CRYSTAL STRUCTURE OF THE PUB DOMAIN OF E3 UBIQUITIN LIGASETITL 2 RNF31REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4f52 GLMN structure of a glomulin-rbx1-cul1 complex 3.0Å AUTH D.M.DUDA,J.L.OLSZEWSKI,A.E.TRON,M.HAMMEL,L.J.LAMBERT,AUTH 2 M.B.WADDELL,T.MITTAG,J.A.DECAPRIO,B.A.SCHULMANTITL STRUCTURE OF A GLOMULIN-RBX1-CUL1 COMPLEX: INHIBITION OF ATITL 2 RING E3 LIGASE THROUGH MASKING OF ITS E2-BINDING SURFACE.REF MOL.CELL V. 47 371 2012REFN ISSN 1097-2765PMID 22748924DOI 10.1016/J.MOLCEL.2012.05.044 Variant Set Distributions Mapped Variants
General Structure Information 3ddt TRIM63 crystal structure of the b2 box from murf1 in dimeric state 1.9Å AUTH M.MROSEK,S.MEIER,Z.UCURUM-FOTIADIS,E.VON CASTELMUR,AUTH 2 E.HEDBOM,A.LUSTIG,S.GRZESIEK,D.LABEIT,S.LABEIT,AUTH 3 O.MAYANSTITL STRUCTURAL ANALYSIS OF B-BOX 2 FROM MURF1:TITL 2 IDENTIFICATION OF A NOVEL SELF-ASSOCIATION PATTERNTITL 3 IN A RING-LIKE FOLDREF BIOCHEMISTRY V. 47 10722 2008REFN ISSN 0006-2960PMID 18795805DOI 10.1021/BI800733Z Variant Set Distributions […]
General Structure Information 4ljq RNF31 crystal structure of the catalytic core of e3 ligase hoip 2.45Å AUTH B.STIEGLITZ,R.R.RANA,M.G.KOLIOPOULOS,A.C.MORRIS-DAVIES,AUTH 2 V.SCHAEFFER,E.CHRISTODOULOU,S.HOWELL,N.R.BROWN,I.DIKIC,AUTH 3 K.RITTINGERTITL STRUCTURAL BASIS FOR LIGASE-SPECIFIC CONJUGATION OF LINEARTITL 2 UBIQUITIN CHAINS BY HOIP.REF NATURE V. 503 422 2013REFN ISSN 0028-0836PMID 24141947DOI 10.1038/NATURE12638 Variant Set Distributions Mapped Variants
General Structure Information 2a7l UBE2W structure of the human hypothetical ubiquitin-conjugating enzyme, loc55284 1.82Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 2xoc CHFR c-terminal cysteine-rich domain of human chfr bound to madpr 1.89Å AUTH J.OBEROI,M.W.RICHARDS,S.CRUMPLER,N.BROWN,J.BLAGG,AUTH 2 R.BAYLISSTITL STRUCTURAL BASIS OF POLY(ADP-RIBOSE) RECOGNITIONTITL 2 BY THE MULTIZINC BINDING DOMAIN OF CHECKPOINT WITHTITL 3 FORKHEAD-ASSOCIATED AND RING DOMAINS (CHFR).REF J.BIOL.CHEM. V. 285 39348 2010REFN ISSN 0021-9258PMID 20880844DOI 10.1074/JBC.M110.159855 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4dbg RNF31 crystal structure of hoil-1l-ubl complexed with a hoip-uba derivative 2.71Å AUTH H.YAGI,K.ISHIMOTO,T.HIROMOTO,H.FUJITA,T.MIZUSHIMA,Y.UEKUSA,AUTH 2 M.YAGI-UTSUMI,E.KURIMOTO,M.NODA,S.UCHIYAMA,F.TOKUNAGA,AUTH 3 K.IWAI,K.KATOTITL A NON-CANONICAL UBA-UBL INTERACTION FORMS THETITL 2 LINEAR-UBIQUITIN-CHAIN ASSEMBLY COMPLEXREF EMBO REP. V. 13 462 2012REFN ISSN 1469-221XPMID 22430200DOI 10.1038/EMBOR.2012.24 Variant Set Distributions Mapped Variants
General Structure Information 2dmf RNF25 an extended conformation of the rwd domain of human ring finger protein 25 -1.0Å AUTH M.YONEYAMA,N.TOCHIO,S.KOSHIBA,S.WATABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL AN EXTENDED CONFORMATION OF THE RWD DOMAIN OFTITL 2 HUMAN RING FINGER PROTEIN 25REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1y6l UBE2E2 human ubiquitin conjugating enzyme e2e2 1.85Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants