Assessment of Structural Intolerance and Durability
General Structure Information 3rpg RNF2 bmi1/ring1b-ubch5c complex structure 2.65Å AUTH M.L.BENTLEY,J.E.CORN,K.C.DONG,Q.PHUNG,T.K.CHEUNG,A.G.COCHRANTITL RECOGNITION OF UBCH5C AND THE NUCLEOSOME BY THE BMI1/RING1BTITL 2 UBIQUITIN LIGASE COMPLEX.REF EMBO J. V. 30 3285 2011REFN ISSN 0261-4189PMID 21772249DOI 10.1038/EMBOJ.2011.243 Variant Set Distributions Mapped Variants
General Structure Information 2ejm MCCC1 solution structure of ruh-072, an apo-biotnyl domain form human acetyl coenzyme a carboxylase -1.0Å AUTH A.Z.M.RUHUL MOMEN,H.HIROTA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RUH-072, AN APO-BIOTNYLTITL 2 DOMAIN FORM HUMAN ACETYL COENZYME A CARBOXYLASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2nsq NEDD4L crystal structure of the c2 domain of the human e3 ubiquitin-protein ligase nedd4-like protein 1.85Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL THE C2 DOMAIN OF THE HUMAN E3 UBIQUITIN-PROTEIN LIGASETITL 2 NEDD4-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2lgy RBCK1 ubiquitin-like domain from hoil-1 -1.0Å AUTH S.A.BEASLEY,S.S.SAFADI,K.R.BARBER,G.S.SHAWTITL SOLUTION STRUCTURE OF THE E3 LIGASE HOIL-1 UBL DOMAIN.REF PROTEIN SCI. V. 21 1085 2012REFN ISSN 0961-8368PMID 22517668DOI 10.1002/PRO.2080 Variant Set Distributions Mapped Variants
General Structure Information 3oln UHRF2 crystal structure of the sra domain of e3 ubiquitin-protein ligase uhrf2 2.3Å AUTH J.R.WALKER,S.XUE,G.V.AVVAKUMOV,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANON,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE SET AND RING ASSOCIATED (SRA) DOMAIN OF HUMANTITL 2 UBIQUITIN-LIKE CONTAINING PHD AND RING FINGER DOMAINS 2TITL 3 (UHRF2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yrg TRIM5 solution structure of the b-box domain from tripartite motif-containing protein 5 -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE B-BOX DOMAIN FROMTITL 2 TRIPARTITE MOTIF-CONTAINING PROTEIN 5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3jw0 NEDD4L e2~ubiquitin-hect 3.1Å AUTH H.B.KAMADURAI,J.SOUPHRON,D.C.SCOTT,D.M.DUDA,D.J.MILLER,AUTH 2 D.STRINGER,R.C.PIPER,B.A.SCHULMANTITL INSIGHTS INTO UBIQUITIN TRANSFER CASCADES FROM A STRUCTURETITL 2 OF A UBCH5B APPROXIMATELY UBIQUITIN-HECT(NEDD4L) COMPLEX.REF MOL.CELL V. 36 1095 2009REFN ISSN 1097-2765PMID 20064473DOI 10.1016/J.MOLCEL.2009.11.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1wy8 UHRF2 solution structure of the n-terminal ubiquitin-like domain in human np95/icbp90-like ring finger protein (nirf) -1.0Å AUTH C.ZHAO,K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINALTITL 2 UBIQUITIN-LIKE DOMAIN IN HUMAN NP95/ICBP90-LIKETITL 3 RING FINGER PROTEIN (NIRF)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1nd7 WWP1 conformational flexibility underlies ubiquitin ligation mediated by the wwp1 hect domain e3 ligase 2.1Å AUTH M.A.VERDECIA,C.A.P.JOAZIERO,N.J.WELLS,J.-L.FERRER,AUTH 2 M.E.BOWMAN,T.HUNTER,J.P.NOELTITL CONFORMATIONAL FLEXIBILITY UNDERLIES UBIQUITINTITL 2 LIGATION MEDIATED BY THE WWP1 HECT DOMAIN E3 LIGASEREF MOL.CELL V. 11 249 2003REFN ISSN 1097-2765PMID 12535537DOI 10.1016/S1097-2765(02)00774-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3nw0 NDNL2 crystal structure of mageg1 and nse1 complex 2.92Å AUTH J.M.DOYLE,J.GAO,J.WANG,M.YANG,P.R.POTTSTITL MAGE-RING PROTEIN COMPLEXES COMPRISE A FAMILY OF E3TITL 2 UBIQUITIN LIGASES.REF MOL.CELL V. 39 963 2010REFN ISSN 1097-2765PMID 20864041DOI 10.1016/J.MOLCEL.2010.08.029 Variant Set Distributions Mapped Variants