Assessment of Structural Intolerance and Durability
General Structure Information 2iwi PIM2 crystal structure of the human pim2 in complex with a ruthenium organometallic ligand ru1 2.8Å AUTH A.N.BULLOCK,S.RUSSO,A.AMOS,N.PAGANO,H.BREGMAN,AUTH 2 J.E.DEBRECZENI,W.H.LEE,F.VON DELFT,E.MEGGERS,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF THE PIM2 KINASE IN COMPLEXTITL 2 WITH AN ORGANORUTHENIUM INHIBITOR.REF PLOS ONE V. 4 E7112 2009REFN ISSN 1932-6203PMID 19841674DOI 10.1371/JOURNAL.PONE.0007112 Variant Set Distributions Ripley’s K […]
General Structure Information 3c9q WDYHV1 crystal structure of the uncharacterized human protein c8orf32 with bound peptide 1.5Å AUTH E.BITTO,C.A.BINGMAN,J.G.MCCOY,G.E.WESENBERG,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF THE UNCHARACTERIZED HUMAN PROTEINTITL 2 C8ORF32 WITH BOUND PEPTIDE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2lxs CREBBP allosteric communication in the kix domain proceeds through dynamic re-packing of the hydrophobic core -1.0Å AUTH S.BRUSCHWEILER,R.KONRAT,M.TOLLINGERTITL ALLOSTERIC COMMUNICATION IN THE KIX DOMAIN PROCEEDS THROUGHTITL 2 DYNAMIC REPACKING OF THE HYDROPHOBIC CORE.REF ACS CHEM.BIOL. 2013REFN ESSN 1554-8937PMID 23651431DOI 10.1021/CB4002188 Variant Set Distributions Mapped Variants
General Structure Information 2ysm KMT2C solution structure of the first and second phd domain from myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST AND SECOND PHDTITL 2 DOMAIN FROM MYELOID/LYMPHOID OR MIXED-LINEAGETITL 3 LEUKEMIA PROTEIN 3 HOMOLOGREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4esr AHI1 molecular and structural characterization of the sh3 domain of ahi-1 in regulation of cellular resistance of bcr-abl+ chronic myeloid leukemia cells to tyrosine kinase inhibitors 1.53Å AUTH X.LIU,M.CHEN,P.LOBO,J.AN,S.W.GRACE CHENG,A.MORADIAN,AUTH 2 G.B.MORIN,F.VAN PETEGEM,X.JIANGTITL MOLECULAR AND STRUCTURAL CHARACTERIZATION OF THE SH3 DOMAINTITL 2 OF AHI-1 IN REGULATION OF CELLULAR RESISTANCE OF BCR-ABL(+)TITL […]
General Structure Information 2ypa LDB1 structure of the scl:e47:lmo2:ldb1 complex bound to dna 2.8Å AUTH K.EL OMARI,S.J.HOOSDALLY,K.TULADHAR,D.KARIA,E.HALL-PONSELE,AUTH 2 O.PLATONOVA,P.VYAS,R.PATIENT,C.PORCHER,E.J.MANCINITITL STRUCTURAL BASIS FOR LMO2-DRIVEN RECRUITMENT OF THETITL 2 SCL:E47BHLH HETERODIMER TO HEMATOPOIETIC-SPECIFICTITL 3 TRANSCRIPTIONAL TARGETS.REF CELL REP. V. 4 135 2013REFN ISSN 2211-1247PMID 23831025DOI 10.1016/J.CELREP.2013.06.008 Variant Set Distributions Mapped Variants
General Structure Information 4jol RUNX1T1 complex structure of aml1-eto nhr2 domain with heb fragment 2.91Å AUTH X.J.SUN,Z.WANG,L.WANG,Y.JIANG,N.KOST,T.D.SOONG,W.Y.CHEN,AUTH 2 Z.TANG,T.NAKADAI,O.ELEMENTO,W.FISCHLE,A.MELNICK,D.J.PATEL,AUTH 3 S.D.NIMER,R.G.ROEDERTITL A STABLE TRANSCRIPTION FACTOR COMPLEX NUCLEATED BYTITL 2 OLIGOMERIC AML1-ETO CONTROLS LEUKAEMOGENESIS.REF NATURE V. 500 93 2013REFN ISSN 0028-0836PMID 23812588DOI 10.1038/NATURE12287 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3lqh KMT2A crystal structure of mll1 phd3-bromo in the free form 1.72Å AUTH Z.WANG,J.SONG,T.A.MILNE,G.G.WANG,H.LI,C.D.ALLIS,D.J.PATELTITL PRO ISOMERIZATION IN MLL1 PHD3-BROMO CASSETTE CONNECTSTITL 2 H3K4ME READOUT TO CYP33 AND HDAC-MEDIATED REPRESSION.REF CELL(CAMBRIDGE,MASS.) V. 141 1183 2010REFN ISSN 0092-8674PMID 20541251DOI 10.1016/J.CELL.2010.05.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1buo ZBTB16 btb domain from plzf 1.9Å AUTH K.F.AHMAD,C.K.ENGEL,G.G.PRIVETITL CRYSTAL STRUCTURE OF THE BTB DOMAIN FROM PLZF.REF PROC.NATL.ACAD.SCI.USA V. 95 12123 1998REFN ISSN 0027-8424PMID 9770450DOI 10.1073/PNAS.95.21.12123 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pp4 RUNX1T1 solution structure of eto-tafh refined in explicit solvent -1.0Å AUTH Y.WEI,S.LIU,J.LAUSEN,C.WOODRELL,S.CHO,N.BIRIS,AUTH 2 N.KOBAYASHI,Y.WEI,S.YOKOYAMA,M.H.WERNERTITL A TAF4-HOMOLOGY DOMAIN FROM THE COREPRESSOR ETO ISTITL 2 A DOCKING PLATFORM FOR POSITIVE AND NEGATIVETITL 3 REGULATORS OF TRANSCRIPTIONREF NAT.STRUCT.MOL.BIOL. V. 14 653 2007REFN ISSN 1545-9993PMID 17572682DOI 10.1038/NSMB1258 Variant Set Distributions Ripley’s K Analysis Plots Variant […]