General Structure Information
| PDB ID | 2pp4 |
| HGNC Gene Label(s) | RUNX1T1 |
| Structure Name | solution structure of eto-tafh refined in explicit solvent |
| Resolution | -1.0Å |
| Reference | AUTH Y.WEI,S.LIU,J.LAUSEN,C.WOODRELL,S.CHO,N.BIRIS,AUTH 2 N.KOBAYASHI,Y.WEI,S.YOKOYAMA,M.H.WERNERTITL A TAF4-HOMOLOGY DOMAIN FROM THE COREPRESSOR ETO ISTITL 2 A DOCKING PLATFORM FOR POSITIVE AND NEGATIVETITL 3 REGULATORS OF TRANSCRIPTIONREF NAT.STRUCT.MOL.BIOL. V. 14 653 2007REFN ISSN 1545-9993PMID 17572682DOI 10.1038/NSMB1258 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 107 |
| Number Of SNVs | 13 |
| Number Of Permutations | 1250 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.026 |
| p-value | 0.053 |
COSMIC
| Number Of Residues | 107 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1239 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.036 |
| p-value | 0.74 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 13 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.085 |
| p-value | 0.804 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
