General Structure Information
| PDB ID | 4jol |
| HGNC Gene Label(s) | RUNX1T1 |
| Structure Name | complex structure of aml1-eto nhr2 domain with heb fragment |
| Resolution | 2.91Å |
| Reference | AUTH X.J.SUN,Z.WANG,L.WANG,Y.JIANG,N.KOST,T.D.SOONG,W.Y.CHEN,AUTH 2 Z.TANG,T.NAKADAI,O.ELEMENTO,W.FISCHLE,A.MELNICK,D.J.PATEL,AUTH 3 S.D.NIMER,R.G.ROEDERTITL A STABLE TRANSCRIPTION FACTOR COMPLEX NUCLEATED BYTITL 2 OLIGOMERIC AML1-ETO CONTROLS LEUKAEMOGENESIS.REF NATURE V. 500 93 2013REFN ISSN 0028-0836PMID 23812588DOI 10.1038/NATURE12287 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 60 |
| Number Of SNVs | 9 |
| Number Of Permutations | 2987 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.056 |
| p-value | 0.749 |
COSMIC
| Number Of Residues | 60 |
| Number Of SNVs | 8 |
| Number Of Permutations | 2559 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.714 |
| p-value | 0.176 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 9 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 36.0 |
| K Statistic | 0.302 |
| p-value | 0.261 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
