Assessment of Structural Intolerance and Durability
General Structure Information 1jsg TCL1A crystal structure of p14tcl1, an oncogene product involved in t-cell prolymphocytic leukemia, reveals a novel b- barrel topology 2.5Å AUTH F.HOH,Y.S.YANG,L.GUIGNARD,A.PADILLA,M.H.STERN,AUTH 2 J.M.LHOSTE,H.VAN TILBEURGHTITL CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCTTITL 2 INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA,TITL 3 REVEALS A NOVEL BETA-BARREL TOPOLOGY.REF STRUCTURE V. 6 147 1998REFN ISSN 0969-2126PMID […]
General Structure Information 1hp8 CMC4 solution structure of human p8-mtcp1, a cysteine-rich protein encoded by the mtcp1 oncogene,reveals a new alpha- helical assembly motif, nmr, minimized average structure -1.0Å AUTH P.BARTHE,Y.S.YANG,L.CHICHE,F.HOH,M.P.STRUB,AUTH 2 L.GUIGNARD,J.SOULIER,M.H.STERN,H.VAN TILBEURGH,AUTH 3 J.M.LHOSTE,C.ROUMESTANDTITL SOLUTION STRUCTURE OF HUMAN P8MTCP1, ATITL 2 CYSTEINE-RICH PROTEIN ENCODED BY THE MTCP1TITL 3 ONCOGENE, REVEALS A NEW ALPHA-HELICAL […]
General Structure Information 3cpf EIF5A crystal structure of human eukaryotic translation initiation factor eif5a 2.5Å AUTH Y.TONG,I.PARK,B.S.HONG,L.NEDYALKOVA,W.TEMPEL,H.W.PARKTITL CRYSTAL STRUCTURE OF HUMAN EIF5A1: INSIGHT INTO FUNCTIONALTITL 2 SIMILARITY OF HUMAN EIF5A1 AND EIF5A2.REF PROTEINS V. 75 1040 2009REFN ISSN 0887-3585PMID 19280598DOI 10.1002/PROT.22378 Variant Set Distributions Mapped Variants
General Structure Information 3lqh KMT2A crystal structure of mll1 phd3-bromo in the free form 1.72Å AUTH Z.WANG,J.SONG,T.A.MILNE,G.G.WANG,H.LI,C.D.ALLIS,D.J.PATELTITL PRO ISOMERIZATION IN MLL1 PHD3-BROMO CASSETTE CONNECTSTITL 2 H3K4ME READOUT TO CYP33 AND HDAC-MEDIATED REPRESSION.REF CELL(CAMBRIDGE,MASS.) V. 141 1183 2010REFN ISSN 0092-8674PMID 20541251DOI 10.1016/J.CELL.2010.05.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1buo ZBTB16 btb domain from plzf 1.9Å AUTH K.F.AHMAD,C.K.ENGEL,G.G.PRIVETITL CRYSTAL STRUCTURE OF THE BTB DOMAIN FROM PLZF.REF PROC.NATL.ACAD.SCI.USA V. 95 12123 1998REFN ISSN 0027-8424PMID 9770450DOI 10.1073/PNAS.95.21.12123 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pp4 RUNX1T1 solution structure of eto-tafh refined in explicit solvent -1.0Å AUTH Y.WEI,S.LIU,J.LAUSEN,C.WOODRELL,S.CHO,N.BIRIS,AUTH 2 N.KOBAYASHI,Y.WEI,S.YOKOYAMA,M.H.WERNERTITL A TAF4-HOMOLOGY DOMAIN FROM THE COREPRESSOR ETO ISTITL 2 A DOCKING PLATFORM FOR POSITIVE AND NEGATIVETITL 3 REGULATORS OF TRANSCRIPTIONREF NAT.STRUCT.MOL.BIOL. V. 14 653 2007REFN ISSN 1545-9993PMID 17572682DOI 10.1038/NSMB1258 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1jsg TCL1A crystal structure of p14tcl1, an oncogene product involved in t-cell prolymphocytic leukemia, reveals a novel b- barrel topology 2.5Å AUTH F.HOH,Y.S.YANG,L.GUIGNARD,A.PADILLA,M.H.STERN,AUTH 2 J.M.LHOSTE,H.VAN TILBEURGHTITL CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCTTITL 2 INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA,TITL 3 REVEALS A NOVEL BETA-BARREL TOPOLOGY.REF STRUCTURE V. 6 147 1998REFN ISSN 0969-2126PMID […]
General Structure Information 1hp8 CMC4 solution structure of human p8-mtcp1, a cysteine-rich protein encoded by the mtcp1 oncogene,reveals a new alpha- helical assembly motif, nmr, minimized average structure -1.0Å AUTH P.BARTHE,Y.S.YANG,L.CHICHE,F.HOH,M.P.STRUB,AUTH 2 L.GUIGNARD,J.SOULIER,M.H.STERN,H.VAN TILBEURGH,AUTH 3 J.M.LHOSTE,C.ROUMESTANDTITL SOLUTION STRUCTURE OF HUMAN P8MTCP1, ATITL 2 CYSTEINE-RICH PROTEIN ENCODED BY THE MTCP1TITL 3 ONCOGENE, REVEALS A NEW ALPHA-HELICAL […]
General Structure Information 3cpf EIF5A crystal structure of human eukaryotic translation initiation factor eif5a 2.5Å AUTH Y.TONG,I.PARK,B.S.HONG,L.NEDYALKOVA,W.TEMPEL,H.W.PARKTITL CRYSTAL STRUCTURE OF HUMAN EIF5A1: INSIGHT INTO FUNCTIONALTITL 2 SIMILARITY OF HUMAN EIF5A1 AND EIF5A2.REF PROTEINS V. 75 1040 2009REFN ISSN 0887-3585PMID 19280598DOI 10.1002/PROT.22378 Variant Set Distributions Mapped Variants
General Structure Information 3eto NOTCH1 2 angstrom xray structure of the notch1 negative regulatory region (nrr) 2.0Å AUTH W.R.GORDON,M.ROY,D.VARDAR-ULU,M.GARFINKEL,M.R.MANSOUR,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURE OF THE NOTCH1-NEGATIVE REGULATORY REGION:TITL 2 IMPLICATIONS FOR NORMAL ACTIVATION AND PATHOGENIC SIGNALINGTITL 3 IN T-ALL.REF BLOOD V. 113 4381 2009REFN ISSN 0006-4971PMID 19075186DOI 10.1182/BLOOD-2008-08-174748 Variant Set Distributions Ripley’s K Analysis Plots Variant […]