Assessment of Structural Intolerance and Durability
General Structure Information 2cm0 NGLY1 the pub domain functions as a p97 binding module in human peptide n-glycanase. 1.9Å AUTH M.D.ALLEN,A.BUCHBERGER,M.BYCROFTTITL THE PUB DOMAIN FUNCTIONS AS A P97 BINDING MODULETITL 2 IN HUMAN PEPTIDE N-GLYCANASE.REF J.BIOL.CHEM. V. 281 25502 2006REFN ISSN 0021-9258PMID 16807242DOI 10.1074/JBC.M601173200 Variant Set Distributions Mapped Variants
General Structure Information 1wwv CNKSR1 solution structure of the sam domain of human connector enhancer of ksr-like protein cnk1 -1.0Å AUTH A.GORONCY,T.KIGAWA,S.KOSHIBA,N.KOBAYASHI,N.TOCHIO,AUTH 2 M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM DOMAIN OF HUMANTITL 2 CONNECTOR ENHANCER OF KSR-LIKE PROTEIN CNK1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1nb9 RFK crystal structure of riboflavin kinase 1.7Å AUTH S.KARTHIKEYAN,Q.ZHOU,F.MSEEH,N.V.GRISHIN,A.L.OSTERMAN,AUTH 2 H.ZHANGTITL CRYSTAL STRUCTURE OF HUMAN RIBOFLAVIN KINASE REVEALS A BETATITL 2 BARREL FOLD AND A NOVEL ACTIVE SITE ARCHREF STRUCTURE V. 11 265 2003REFN ISSN 0969-2126PMID 12623014DOI 10.1016/S0969-2126(03)00024-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3lcy TTN titin ig tandem domains a164-a165 2.5Å AUTH Q.CHEN,M.WILMANNSTITL STRUCTURAL INVESTIGATION OF THE TITIN A-BAND TANDEM IGTITL 2 DOMAINS A164-A165REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1tki TTN autoinhibited serine kinase domain of the giant muscle protein titin 2.0Å AUTH O.MAYANS,P.F.VAN DER VEN,M.WILM,A.MUES,P.YOUNG,AUTH 2 D.O.FURST,M.WILMANNS,M.GAUTELTITL STRUCTURAL BASIS FOR ACTIVATION OF THE TITINTITL 2 KINASE DOMAIN DURING MYOFIBRILLOGENESIS.REF NATURE V. 395 863 1998REFN ISSN 0028-0836PMID 9804419DOI 10.1038/27603 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2ysx INPP5D solution structure of the human ship sh2 domain -1.0Å AUTH T.KASAI,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HUMAN SHIP SH2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2wwm TTN crystal structure of the titin m10-obscurin like 1 ig complex in space group p1 2.3Å AUTH S.PERNIGO,A.FUKUZAWA,M.BERTZ,M.HOLT,M.RIEF,R.A.STEINER,AUTH 2 M.GAUTELTITL STRUCTURAL INSIGHT INTO M-BAND ASSEMBLY AND MECHANICS FROMTITL 2 THE TITIN-OBSCURIN-LIKE-1 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 107 2908 2010REFN ISSN 0027-8424PMID 20133654DOI 10.1073/PNAS.0913736107 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2x4f MYLK4 the crystal structure of the human myosin light chain kinase loc340156. 2.67Å AUTH J.R.C.MUNIZ,P.MAHAJAN,P.RELLOS,O.FEDOROV,B.SHRESTHA,J.WANG,AUTH 2 J.M.ELKINS,N.DAGA,R.COCKING,A.CHAIKUAD,T.KROJER,E.UGOCHUKWU,AUTH 3 W.YUE,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 4 C.BOUNTRA,O.GILEADI,S.KNAPPTITL THE CRYSTAL STRUCTURE OF THE HUMAN MYOSIN LIGHT CHAINTITL 2 KINASE LOC340156REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1wfv MAGI2 solution structure of the fifth pdz domain of human membrane associated guanylate kinase inverted-2 (kiaa0705 protein) -1.0Å AUTH N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH PDZ DOMAIN OFTITL 2 HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASETITL 3 INVERTED-2 (KIAA0705 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3gni STRADA structure of strad and mo25 2.35Å AUTH E.ZEQIRAJ,B.M.FILIPPI,S.GOLDIE,I.NAVRATILOVA,J.BOUDEAU,AUTH 2 M.DEAK,D.R.ALESSI,D.M.VAN AALTENTITL ATP AND MO25ALPHA REGULATE THE CONFORMATIONAL STATE OF THETITL 2 STRADALPHA PSEUDOKINASE AND ACTIVATION OF THE LKB1 TUMOURTITL 3 SUPPRESSORREF PLOS BIOL. V. 7 E1000 2009REFN ISSN 1544-9173PMID 19513107DOI 10.1371/JOURNAL.PBIO.1000126 Variant Set Distributions Mapped Variants