3LCY.C | TTN – ASTRID

3LCY.C | TTN

General Structure Information

PDB ID	3lcy
HGNC Gene Label(s)	TTN
Structure Name	titin ig tandem domains a164-a165
Resolution	2.5Å
Reference	AUTH Q.CHEN,M.WILMANNSTITL STRUCTURAL INVESTIGATION OF THE TITIN A-BAND TANDEM IGTITL 2 DOMAINS A164-A165REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	194
Number Of SNVs	42
Number Of Permutations	32720
Optimal Distance Threshold	24.0
K Statistic	0.425
p-value	0.445

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:179402639		E>Q	C:6	(16.81, 3.39, -11.54)
2:179402629	COSM1010373 COSM1010372 COSM1590940 COSM1010371 COSM1010369	G>E	C:9	(8.79, 3.84, -9.41)
2:179402623		R>H	C:11	(7.99, 8.31, -6.99)
2:179402624		R>C	C:11	(7.99, 8.31, -6.99)
2:179402606		V>I	C:17	(-12.04, 8.86, -9.28)
2:179402599	rs374883160	T>K	C:19	(-17.42, 10.50, -12.31)
2:179402600		T>A	C:19	(-17.42, 10.50, -12.31)
2:179402578		Q>R	C:26	(-8.25, 12.22, -15.30)
2:179402576		L>F	C:27	(-7.65, 7.36, -13.71)
2:179402557		G>E	C:33	(12.58, 5.16, -14.75)
2:179402540		I>L	C:39	(3.01, 3.20, -19.50)
2:179402528		R>G	C:43	(-11.13, -3.02, -16.61)
2:179402519		K>E	C:46	(-8.44, -7.92, -20.51)
2:179402500	rs371531675 COSM4087328 COSM4087327 COSM4087324 COSM4087326 COSM4087325	R>Q	C:52	(-14.28, 7.45, -30.03)
2:179402488		M>T	C:56	(-3.89, 6.56, -22.83)
2:179402486		S>P	C:57	(-1.25, 10.91, -21.18)
2:179402473	COSM267673 COSM267674 COSM1231132 COSM267672 COSM267675	R>H	C:61	(7.05, 12.17, -12.49)
2:179402474	rs143556947	R>C	C:61	(7.05, 12.17, -12.49)
2:179402468	rs374666520	H>Y	C:63	(1.99, 8.17, -16.18)
2:179402423	rs532644861	Y>H	C:78	(-9.84, 1.25, -14.27)
2:179402416		C>Y	C:80	(-0.79, 1.23, -14.07)
2:179402417		C>S	C:80	(-0.79, 1.23, -14.07)
2:179402404		N>S	C:84	(12.10, -1.27, -17.00)
2:179402398	rs576759867	V>A	C:86	(15.41, -3.23, -14.35)
2:179402353	rs140025425	P>L	C:101	(-32.11, 6.52, -9.21)
2:179402354		P>S	C:101	(-32.11, 6.52, -9.21)
2:179402329	rs370632563	L>P	C:109	(-41.26, -1.77, -17.02)
2:179402290	rs373182320	R>Q	C:122	(-38.86, -15.52, -11.76)
2:179402276		Y>H	C:127	(-30.50, -0.84, -11.20)
2:179402266	rs369081242	R>H	C:130	(-24.27, 3.08, -9.20)
2:179402238		H>Q	C:139	(-48.81, -6.65, -2.70)
2:179402239		H>R	C:139	(-48.81, -6.65, -2.70)
2:179402231		K>Q	C:142	(-47.41, -5.19, 3.18)
2:179402200		I>T	C:152	(-36.25, -10.09, -2.74)
2:179402201		I>V	C:152	(-36.25, -10.09, -2.74)
2:179402196		E>D	C:153	(-31.74, -11.90, -5.13)
2:179402182	rs377456237	Y>C	C:158	(-30.30, -7.96, -10.66)
2:179402166		M>I	C:163	(-43.78, -14.59, -6.37)
2:179402168		M>L	C:163	(-43.78, -14.59, -6.37)
2:179402164		K>T	C:164	(-42.96, -20.34, -5.02)
2:179402152	rs373473754	R>H	C:168	(-56.78, -14.86, -9.02)
2:179402147	rs369648529	T>S	C:170	(-52.58, -13.97, -2.60)
2:179402120	rs397517780	L>F	C:179	(-35.04, 2.50, -6.92)
2:179402104	rs397517781	G>E	C:184	(-32.75, 9.69, -5.79)
2:179402101		T>R	C:185	(-36.44, 8.38, -5.67)
2:179402102		T>A	C:185	(-36.44, 8.38, -5.67)
2:179402098		V>A	C:186	(-37.26, 5.83, -8.82)
2:179402096		D>H	C:187	(-41.75, 4.64, -8.46)
2:179402089		I>T	C:189	(-46.57, 0.55, -10.33)
2:179402078		E>K	C:193	(-53.68, -9.83, -14.25)
2:179402073		I>M	C:194	(-53.04, -14.42, -11.36)