Assessment of Structural Intolerance and Durability
General Structure Information 1fvr TEK tie2 kinase domain 2.2Å AUTH L.M.SHEWCHUK,A.M.HASSELL,B.ELLIS,W.D.HOLMES,AUTH 2 R.DAVIS,E.L.HORNE,S.H.KADWELL,D.D.MCKEE,J.T.MOORETITL STRUCTURE OF THE TIE2 RTK DOMAIN: SELF-INHIBITIONTITL 2 BY THE NUCLEOTIDE BINDING LOOP, ACTIVATION LOOP,TITL 3 AND C-TERMINAL TAIL.REF STRUCTURE FOLD.DES. V. 8 1105 2000REFN ISSN 0969-2126PMID 11080633DOI 10.1016/S0969-2126(00)00516-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jed PRKCQ the crystal structure of the kinase domain of the protein kinase c theta in complex with nvp-xaa228 at 2.32a resolution. 2.32Å AUTH W.STARK,F.BITSCH,A.BERNER,F.BUELENS,P.GRAFF,AUTH 2 H.DEPERSIN,G.FENDRICH,M.GEISER,R.KNECHT,J.RAHUEL,AUTH 3 G.RUMMEL,J.M.SCHLAEPPI,R.SCHMITZ,A.STRAUSS,J.WAGNERTITL THE CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF THETITL 2 PROTEIN KINASE C THETA IN COMPLEX WITH NVP-XAA228REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 4ic7 MAP2K5 crystal structure of the erk5 kinase domain in complex with an mkk5 binding fragment 2.6Å AUTH G.GLATZ,G.GOGL,A.ALEXA,A.REMENYITITL STRUCTURAL MECHANISM FOR THE SPECIFIC ASSEMBLY ANDTITL 2 ACTIVATION OF THE EXTRACELLULAR SIGNAL REGULATED KINASE 5TITL 3 (ERK5) MODULE.REF J.BIOL.CHEM. V. 288 8596 2013REFN ISSN 0021-9258PMID 23382384DOI 10.1074/JBC.M113.452235 Variant Set Distributions Mapped Variants
General Structure Information 3bpr MERTK crystal structure of catalytic domain of the proto-oncogene tyrosine- protein kinase mer in complex with inhibitor c52 2.8Å AUTH X.HUANG,P.FINERTY,J.R.WALKER,C.BUTLER-COLE,M.VEDADI,AUTH 2 M.SCHAPIRA,S.A.PARKER,B.E.TURK,D.A.THOMPSON,S.DHE-PAGANONTITL STRUCTURAL INSIGHTS INTO THE INHIBITED STATES OF THE MERTITL 2 RECEPTOR TYROSINE KINASE.REF J.STRUCT.BIOL. V. 165 88 2009REFN ISSN 1047-8477PMID 19028587DOI 10.1016/J.JSB.2008.10.003 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1f3m PAK1 crystal structure of human serine/threonine kinase pak1 2.3Å AUTH M.LEI,W.LU,W.MENG,M.C.PARRINI,M.J.ECK,B.J.MAYER,AUTH 2 S.C.HARRISONTITL STRUCTURE OF PAK1 IN AN AUTOINHIBITED CONFORMATIONTITL 2 REVEALS A MULTISTAGE ACTIVATION SWITCH.REF CELL(CAMBRIDGE,MASS.) V. 102 387 2000REFN ISSN 0092-8674PMID 10975528DOI 10.1016/S0092-8674(00)00043-X Variant Set Distributions Mapped Variants
General Structure Information 4oav RNASEL complete human rnase l in complex with 2-5a (5-ppp heptamer), amppcp and rna substrate. 2.1Å AUTH Y.HAN,J.DONOVAN,S.RATH,G.WHITNEY,A.CHITRAKAR,A.KORENNYKHTITL STRUCTURE OF HUMAN RNASE L REVEALS THE BASIS FOR REGULATEDTITL 2 RNA DECAY IN THE IFN RESPONSE.REF SCIENCE V. 343 1244 2014REFN ISSN 0036-8075PMID 24578532DOI 10.1126/SCIENCE.1249845 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3com STK4 crystal structure of mst1 kinase 2.2Å AUTH S.ATWELL,S.K.BURLEY,M.DICKEY,B.LEON,J.M.SAUDERTITL CRYSTAL STRUCTURE OF MST1 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fww MST1R crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase 1.85Å AUTH K.L.CHAO,I.W.TSAI,C.CHEN,O.HERZBERGTITL CRYSTAL STRUCTURE OF THE SEMA-PSI EXTRACELLULAR DOMAIN OFTITL 2 HUMAN RON RECEPTOR TYROSINE KINASE.REF PLOS ONE V. 7 41912 2012REFN ESSN 1932-6203PMID 22848655DOI 10.1371/JOURNAL.PONE.0041912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4ark MAP2K1 crystal structure of the catalytic domain of human map kinase kinase 1 (mek1) in complex with a small molecule inhibitor and adp 2.6Å AUTH I.V.HARTUNG,M.HITCHCOCK,F.PUEHLER,R.NEUHAUS,A.SCHOLZ,AUTH 2 S.HAMMER,K.PETERSEN,G.SIEMEISTER,D.BRITTAIN,R.C.HILLIGTITL OPTIMIZATION OF ALLOSTERIC MEK INHIBITORS – PART 1:TITL 2 VENTURING INTO UNEXPLORED SAR TERRITORIESREF BIOORG.MED.CHEM.LETT. V. 23 2384 2013REFN ISSN 0960-894XPMID 23474388DOI 10.1016/J.BMCL.2013.02.028 […]
General Structure Information 2yuq ITK solution structure of the sh3 domain of human tyrosine- protein kinase itk/tsk -1.0Å AUTH H.ABE,K.MIYAMOTO,N.TOCHIO,M.SATO,S.KOSHIBA,AUTH 2 T.HARADA,S.WATANABE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF HUMANTITL 2 TYROSINE-PROTEIN KINASE ITK/TSKREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants