General Structure Information
| PDB ID | 4ark |
| HGNC Gene Label(s) | MAP2K1 |
| Structure Name | crystal structure of the catalytic domain of human map kinase kinase 1 (mek1) in complex with a small molecule inhibitor and adp |
| Resolution | 2.6Å |
| Reference | AUTH I.V.HARTUNG,M.HITCHCOCK,F.PUEHLER,R.NEUHAUS,A.SCHOLZ,AUTH 2 S.HAMMER,K.PETERSEN,G.SIEMEISTER,D.BRITTAIN,R.C.HILLIGTITL OPTIMIZATION OF ALLOSTERIC MEK INHIBITORS – PART 1:TITL 2 VENTURING INTO UNEXPLORED SAR TERRITORIESREF BIOORG.MED.CHEM.LETT. V. 23 2384 2013REFN ISSN 0960-894XPMID 23474388DOI 10.1016/J.BMCL.2013.02.028 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 290 |
| Number Of SNVs | 34 |
| Number Of Permutations | 16824 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.246 |
| p-value | 0.35 |
ClinVar
| Number Of Residues | 290 |
| Number Of SNVs | 8 |
| Number Of Permutations | 3467 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.179 |
| p-value | 0.17 |
COSMIC
| Number Of Residues | 290 |
| Number Of SNVs | 16 |
| Number Of Permutations | 12710 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.092 |
| p-value | 0.165 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of ClinVar SNVs | 8 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.122 |
| p-value | 0.126 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of COSMIC SNVs | 15 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.192 |
| p-value | 0.069 |