Assessment of Structural Intolerance and Durability
General Structure Information 1qkq CLC charcot-leyden crystal protein – mannose complex 1.8Å AUTH G.J.SWAMINATHAN,D.D.LEONIDAS,M.P.SAVAGE,AUTH 2 S.J.ACKERMAN,K.R.ACHARYATITL SELECTIVE RECOGNITION OF MANNOSE BY THE HUMANTITL 2 EOSINOPHIL CHARCOT-LEYDEN CRYSTAL PROTEINTITL 3 (GALECTIN-10): A CRYSTALLOGRAPHIC STUDY AT 1.8 ATITL 4 RESOLUTIONREF BIOCHEMISTRY V. 38 13837 1999REFN ISSN 0006-2960PMID 10563827 Variant Set Distributions Mapped Variants
General Structure Information 2cfv PTPRJ crystal structure of human protein tyrosine phosphatase receptor type j 2.5Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bxm FOLH1 structure of an inactive mutant of human glutamate carboxypeptidase ii [gcpii(e424a)] in complex with n-acetyl-asp-glu (naag) 1.71Å AUTH V.KLUSAK,C.BARINKA,A.PLECHANOVOVA,P.MLCOCHOVA,J.KONVALINKA,AUTH 2 L.RULISEK,J.LUBKOWSKITITL REACTION MECHANISM OF GLUTAMATE CARBOXYPEPTIDASE II REVEALEDTITL 2 BY MUTAGENESIS, X-RAY CRYSTALLOGRAPHY, AND COMPUTATIONALTITL 3 METHODS.REF BIOCHEMISTRY V. 48 4126 2009REFN ISSN 0006-2960PMID 19301871DOI 10.1021/BI900220S Variant Set Distributions Ripley’s […]
General Structure Information 4kx9 ENPEP crystal structure of human aminopeptidase a complexed with arginine 2.25Å AUTH Y.YANG,C.LIU,Y.L.LIN,F.LITITL STRUCTURAL INSIGHTS INTO CENTRAL HYPERTENSION REGULATION BYTITL 2 HUMAN AMINOPEPTIDASE A.REF J.BIOL.CHEM. V. 288 25638 2013REFN ISSN 0021-9258PMID 23888046DOI 10.1074/JBC.M113.494955 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yd9 PTPRS crystal structure of the n-terminal ig1-3 module of human receptor protein tyrosine phosphatase sigma 2.6Å AUTH C.H.COLES,Y.SHEN,A.P.TENNEY,C.SIEBOLD,G.C.SUTTON,W.LU,AUTH 2 J.T.GALLAGHER,E.Y.JONES,J.G.FLANAGAN,A.R.ARICESCUTITL PROTEOGLYCAN-SPECIFIC MOLECULAR SWITCH FOR RPTP SIGMATITL 2 CLUSTERING AND NEURONAL EXTENSION.REF SCIENCE V. 332 484 2011REFN ISSN 0036-8075PMID 21454754DOI 10.1126/SCIENCE.1200840 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3ll8 PPP3CA crystal structure of calcineurin in complex with akap79 peptide 2.0Å AUTH H.LI,M.D.PINK,J.G.MURPHY,A.STEIN,M.L.DELLACQUA,P.G.HOGANTITL BALANCED INTERACTIONS OF CALCINEURIN WITH AKAP79 REGULATETITL 2 CA(2+)-CALCINEURIN-NFAT SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 19 337 2012REFN ISSN 1545-9993PMID 22343722DOI 10.1038/NSMB.2238 Variant Set Distributions Mapped Variants
General Structure Information 2qyn PDE4D crystal structure of pde4d2 in complex with inhibitor npv 1.57Å AUTH H.WANG,M.S.PENG,Y.CHEN,J.GENG,H.ROBINSON,AUTH 2 M.D.HOUSLAY,J.CAI,H.KETITL STRUCTURES OF THE FOUR SUBFAMILIES OFTITL 2 PHOSPHODIESTERASE-4 PROVIDE INSIGHT INTO THETITL 3 SELECTIVITY OF THEIR INHIBITORS.REF BIOCHEM.J. V. 408 193 2007REFN ISSN 0264-6021PMID 17727341DOI 10.1042/BJ20070970 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2qym PDE4C crystal structure of unliganded pde4c2 1.9Å AUTH H.WANG,M.S.PENG,Y.CHEN,J.GENG,H.ROBINSON,AUTH 2 M.D.HOUSLAY,J.CAI,H.KETITL STRUCTURES OF THE FOUR SUBFAMILIES OFTITL 2 PHOSPHODIESTERASE-4 PROVIDE INSIGHT INTO THETITL 3 SELECTIVITY OF THEIR INHIBITORS.REF BIOCHEM.J. V. 408 193 2007REFN ISSN 0264-6021PMID 17727341DOI 10.1042/BJ20070970 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3sag EXOSC10 crystal structure of the human rrp6 catalytic domain with d313n mutation in the active site 2.7Å AUTH K.JANUSZYK,Q.LIU,C.D.LIMATITL ACTIVITIES OF HUMAN RRP6 AND STRUCTURE OF THE HUMAN RRP6TITL 2 CATALYTIC DOMAIN.REF RNA V. 17 1566 2011REFN ISSN 1355-8382PMID 21705430DOI 10.1261/RNA.2763111 Variant Set Distributions Mapped Variants
General Structure Information 2kie OCRL a ph domain within ocrl bridges clathrin mediated membrane trafficking to phosphoinositide metabolis -1.0Å AUTH Y.MAO,D.M.BALKIN,R.ZONCU,K.S.ERDMANN,L.TOMASINI,AUTH 2 F.HU,M.M.JIN,M.E.HODSDON,P.DE CAMILLITITL A PH DOMAIN WITHIN OCRL BRIDGES CLATHRIN-MEDIATEDTITL 2 MEMBRANE TRAFFICKING TO PHOSPHOINOSITIDE METABOLISMREF EMBO J. V. 28 1831 2009REFN ISSN 0261-4189PMID 19536138DOI 10.1038/EMBOJ.2009.155 Variant Set Distributions Mapped Variants