Assessment of Structural Intolerance and Durability
General Structure Information 3d59 PLA2G7 crystal structure of human plasma platelet activating factor acetylhydrolase 1.5Å AUTH U.SAMANTA,B.J.BAHNSONTITL CRYSTAL STRUCTURE OF HUMAN PLASMATITL 2 PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE:TITL 3 STRUCTURAL IMPLICATION TO LIPOPROTEIN BINDING ANDTITL 4 CATALYSIS.REF J.BIOL.CHEM. V. 283 31617 2008REFN ISSN 0021-9258PMID 18784071DOI 10.1074/JBC.M804750200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3ezz DUSP4 crystal structure of human mkp-2 2.9Å AUTH D.G.JEONG,S.K.JUNG,T.S.YOON,E.J.WOO,J.H.KIM,AUTH 2 B.C.PARK,S.E.RYU,S.J.KIMTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMANTITL 2 MKP-2 REVEALS A 24-MER ASSEMBLY.REF PROTEINS V. 76 763 2009REFN ISSN 0887-3585PMID 19415758DOI 10.1002/PROT.22423 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1wch PTPN13 crystal structure of ptpl1 human tyrosine phosphatase mutated in colorectal cancer – evidence for a second phosphotyrosine substrate recognition pocket 1.85Å AUTH F.VILLA,M.DEAK,G.B.BLOOMBERG,D.R.ALESSI,AUTH 2 D.M.F.VAN AALTENTITL CRYSTAL STRUCTURE OF PTPL1/FAP-1 HUMAN TYROSINETITL 2 PHOSPHATASE MUTATED IN COLORECTAL CANCER:TITL 3 EVEIDENCE FOR A SECOND PHOSPHOTYROSINE SUBSTRATETITL 4 RECOGNITION POCKETREF J.BIOL.CHEM. V. […]
General Structure Information 2ee5 ARHGAP5 solution structure of the n-teruminus extended rhogap domain from human rho gtpase activating protein 5 variant -1.0Å AUTH T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERUMINUS EXTENDEDTITL 2 RHOGAP DOMAIN FROM HUMAN RHO GTPASE ACTIVATINGTITL 3 PROTEIN 5 VARIANTREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3llm DHX9 crystal structure analysis of a rna helicase 2.8Å AUTH P.SCHUTZ,E.WAHLBERG,T.KARLBERG,M.HAMMARSTROM,R.COLLINS,AUTH 2 A.FLORES,H.SCHULERTITL CRYSTAL STRUCTURE OF HUMAN RNA HELICASE A (DHX9): STRUCTURALTITL 2 BASIS FOR UNSELECTIVE NUCLEOTIDE BASE BINDING IN A DEAD-BOXTITL 3 VARIANT PROTEIN.REF J.MOL.BIOL. V. 400 768 2010REFN ISSN 0022-2836PMID 20510246DOI 10.1016/J.JMB.2010.05.046 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2fh7 PTPRS crystal structure of the phosphatase domains of human ptp sigma 2.0Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2kmv ATP7A solution structure of the nucleotide binding domain of the human menkes protein in the atp-free form -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,S.INAGAKI,M.MIGLIARDI,AUTH 2 A.ROSATOTITL THE BINDING MODE OF ATP REVEALED BY THE SOLUTIONTITL 2 STRUCTURE OF THE N-DOMAIN OF HUMAN ATP7A.REF J.BIOL.CHEM. 2009REFN ESSN 1083-351XPMID 19917612DOI 10.1074/JBC.M109.054262 Variant Set Distributions Mapped Variants
General Structure Information 3g45 PDE4B crystal structure of human phosphodiesterase 4b with regulatory domain and d155988 2.63Å AUTH A.B.BURGIN,O.T.MAGNUSSON,J.SINGH,P.WITTE,AUTH 2 B.L.STAKER,J.M.BJORNSSON,M.THORSTEINSDOTTIR,AUTH 3 S.HRAFNSDOTTIR,T.HAGEN,A.S.KISELYOV,L.J.STEWART,AUTH 4 M.E.GURNEYTITL DESIGN OF PHOSPHODIESTERASE 4D (PDE4D) ALLOSTERICTITL 2 MODULATORS FOR ENHANCING COGNITION WITH IMPROVEDTITL 3 SAFETY.REF NAT.BIOTECHNOL. V. 28 63 2010REFN ISSN 1087-0156PMID 20037581DOI 10.1038/NBT.1598 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2g9o ATP7A solution structure of the apo form of the third metal- binding domain of atp7a protein (menkes disease protein) -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,N.DELLAMALVA,AUTH 2 T.HERRMANN,A.ROSATO,K.WUTHRICHTITL SOLUTION STRUCTURE AND INTERMOLECULAR INTERACTIONSTITL 2 OF THE THIRD METAL-BINDING DOMAIN OF ATP7A, THETITL 3 MENKES DISEASE PROTEIN.REF J.BIOL.CHEM. V. 281 29141 2006REFN ISSN 0021-9258PMID 16873374DOI 10.1074/JBC.M603176200 […]
General Structure Information 1aw0 ATP7A fourth metal-binding domain of the menkes copper- transporting atpase, nmr, 20 structures -1.0Å AUTH J.GITSCHIER,B.MOFFAT,D.REILLY,W.I.WOOD,AUTH 2 W.J.FAIRBROTHERTITL SOLUTION STRUCTURE OF THE FOURTH METAL-BINDINGTITL 2 DOMAIN FROM THE MENKES COPPER-TRANSPORTING ATPASE.REF NAT.STRUCT.BIOL. V. 5 47 1998REFN ISSN 1072-8368PMID 9437429DOI 10.1038/NSB0198-47 Variant Set Distributions Mapped Variants