Assessment of Structural Intolerance and Durability
General Structure Information 3bg0 SEC13 architecture of a coat for the nuclear pore membrane 3.15Å AUTH K.C.HSIA,P.STAVROPOULOS,G.BLOBEL,A.HOELZTITL ARCHITECTURE OF A COAT FOR THE NUCLEAR PORETITL 2 MEMBRANE.REF CELL(CAMBRIDGE,MASS.) V. 131 1313 2007REFN ISSN 0092-8674PMID 18160040DOI 10.1016/J.CELL.2007.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1w50 BACE1 apo structure of bace (beta secretase) 1.75Å AUTH S.PATEL,L.VUILLARD,A.CLEASBY,C.W.MURRAY,J.YONTITL APO AND INHIBITOR COMPLEX STRUCTURES OF BACETITL 2 (BETA-SECRETASE)REF J.MOL.BIOL. V. 343 407 2004REFN ISSN 0022-2836PMID 15451669DOI 10.1016/J.JMB.2004.08.018 Variant Set Distributions Mapped Variants
General Structure Information 2zu6 EIF4A1 crystal structure of the eif4a-pdcd4 complex 2.8Å AUTH J.H.CHANG,Y.H.CHO,S.Y.SOHN,J.M.CHOI,A.KIM,Y.C.KIM,AUTH 2 S.K.JANG,Y.CHOTITL CRYSTAL STRUCTURE OF THE EIF4A-PDCD4 COMPLEXREF PROC.NATL.ACAD.SCI.USA V. 106 3148 2009REFN ISSN 0027-8424PMID 19204291DOI 10.1073/PNAS.0808275106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dpr VLDLR human rhinovirus 2 bound to a concatamer of the vldl receptor module v3 3.5Å AUTH J.QUEROL-AUDI,T.KONECSNI,J.POUS,O.CARUGO,I.FITA,N.VERDAGUER,AUTH 2 D.BLAASTITL MINOR GROUP HUMAN RHINOVIRUS-RECEPTOR INTERACTIONS: GEOMETRYTITL 2 OF MULTIMODULAR ATTACHMENT AND BASIS OF RECOGNITIONREF FEBS LETT. V. 583 235 2009REFN ISSN 0014-5793PMID 19073182DOI 10.1016/J.FEBSLET.2008.12.014 Variant Set Distributions Mapped Variants
General Structure Information 4j6s YWHAG 14-3-3gamma complexed with the n-terminal sequence of tyrosine hydroxylase (residues 1-43) 3.08Å AUTH A.A.SKJEVIK,M.MILENI,A.BAUMANN,O.HALSKAU,K.TEIGEN,AUTH 2 R.C.STEVENS,A.MARTINEZTITL THE N-TERMINAL SEQUENCE OF TYROSINE HYDROXYLASE IS ATITL 2 CONFORMATIONALLY VERSATILE MOTIF THAT BINDS 14-3-3 PROTEINSTITL 3 AND MEMBRANES.REF J.MOL.BIOL. V. 426 150 2014REFN ISSN 0022-2836PMID 24055376DOI 10.1016/J.JMB.2013.09.012 Variant Set Distributions Mapped Variants
General Structure Information 1so2 PDE3B catalytic domain of human phosphodiesterase 3b in complex with a dihydropyridazine inhibitor 2.4Å AUTH G.SCAPIN,S.B.PATEL,C.CHUNG,J.P.VARNERIN,AUTH 2 S.D.EDMONDSON,A.MASTRACCHIO,E.R.PARMEE,S.B.SINGH,AUTH 3 J.W.BECKER,L.H.VAN DER PLOEG,M.R.TOTATITL CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 3B:TITL 2 ATOMIC BASIS FOR SUBSTRATE AND INHIBITORTITL 3 SPECIFICITYREF BIOCHEMISTRY V. 43 6091 2004REFN ISSN 0006-2960PMID 15147193DOI 10.1021/BI049868I Variant Set Distributions Ripley’s K […]
General Structure Information 1ywh PLAUR crystal structure of urokinase plasminogen activator receptor 2.7Å AUTH P.LLINAS,M.H.LE DU,H.GARDSVOLL,K.DANO,M.PLOUG,B.GILQUIN,AUTH 2 E.A.STURA,A.MENEZTITL CRYSTAL STRUCTURE OF THE HUMAN UROKINASE PLASMINOGENTITL 2 ACTIVATOR RECEPTOR BOUND TO AN ANTAGONIST PEPTIDEREF EMBO J. V. 24 1655 2005REFN ISSN 0261-4189PMID 15861141DOI 10.1038/SJ.EMBOJ.7600635 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4i5k PPP2R3A pp2a pr70 holoenzyme model3_dica_rcsb.pdb bppnat5_extend.mtz 2.9Å AUTH N.WLODARCHAK,F.GUO,K.A.SATYSHUR,L.JIANG,P.D.JEFFREY,T.SUN,AUTH 2 V.STANEVICH,M.C.MUMBY,Y.XINGTITL STRUCTURE OF THE CA(2+)-DEPENDENT PP2A HETEROTRIMER ANDTITL 2 INSIGHTS INTO CDC6 DEPHOSPHORYLATION.REF CELL RES. V. 23 931 2013REFN ISSN 1001-0602PMID 23752926DOI 10.1038/CR.2013.77 Variant Set Distributions Mapped Variants
General Structure Information 2y6e USP4 structure of the d1d2 domain of usp4, the conserved catalytic domain 2.4Å AUTH M.CLERICI,M.P.A.LUNA-VARGAS,A.C.FAESEN,T.K.SIXMATITL THE DUSP-UBL DOMAIN OF USP4 ENHANCES ITS CATALYTICTITL 2 EFFICIENCY BY PROMOTING UBIQUITIN EXCHANGE.REF NAT.COMMUN. V. 5 5399 2014REFN ISSN 2041-1723PMID 25404403DOI 10.1038/NCOMMS6399 Variant Set Distributions Mapped Variants
General Structure Information 3q90 G3BP1 crystal structure of the ntf2 domain of ras gtpase-activating protein- binding protein 1 1.7Å AUTH M.WELIN,L.TRESAUGUES,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,T.EKBLAD,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE NTF2 DOMAIN OF RASTITL 2 GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]