Assessment of Structural Intolerance and Durability
General Structure Information 2g9o ATP7A solution structure of the apo form of the third metal- binding domain of atp7a protein (menkes disease protein) -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,N.DELLAMALVA,AUTH 2 T.HERRMANN,A.ROSATO,K.WUTHRICHTITL SOLUTION STRUCTURE AND INTERMOLECULAR INTERACTIONSTITL 2 OF THE THIRD METAL-BINDING DOMAIN OF ATP7A, THETITL 3 MENKES DISEASE PROTEIN.REF J.BIOL.CHEM. V. 281 29141 2006REFN ISSN 0021-9258PMID 16873374DOI 10.1074/JBC.M603176200 […]
General Structure Information 1aw0 ATP7A fourth metal-binding domain of the menkes copper- transporting atpase, nmr, 20 structures -1.0Å AUTH J.GITSCHIER,B.MOFFAT,D.REILLY,W.I.WOOD,AUTH 2 W.J.FAIRBROTHERTITL SOLUTION STRUCTURE OF THE FOURTH METAL-BINDINGTITL 2 DOMAIN FROM THE MENKES COPPER-TRANSPORTING ATPASE.REF NAT.STRUCT.BIOL. V. 5 47 1998REFN ISSN 1072-8368PMID 9437429DOI 10.1038/NSB0198-47 Variant Set Distributions Mapped Variants
General Structure Information 4jmk DUSP8 structure of dusp8 1.9Å AUTH D.G.JEONG,C.H.WEI,B.KU,T.J.JEON,P.N.CHIEN,J.K.KIM,S.Y.PARK,AUTH 2 H.S.HWANG,S.Y.RYU,H.PARK,D.S.KIM,S.J.KIM,S.E.RYUTITL THE FAMILY-WIDE STRUCTURE AND FUNCTION OF HUMANTITL 2 DUAL-SPECIFICITY PROTEIN PHOSPHATASESREF ACTA CRYSTALLOGR.,SECT.D V. 70 421 2014REFN ISSN 0907-4449DOI 10.1107/S1399004713029866 Variant Set Distributions Mapped Variants
General Structure Information 3snh DNM1 crystal structure of nucleotide-free human dynamin1 3.7Å AUTH K.FAELBER,Y.POSOR,S.GAO,M.HELD,Y.ROSKE,D.SCHULZE,V.HAUCKE,AUTH 2 F.NOE,O.DAUMKETITL CRYSTAL STRUCTURE OF NUCLEOTIDE-FREE DYNAMIN.REF NATURE V. 477 556 2011REFN ISSN 0028-0836PMID 21927000DOI 10.1038/NATURE10369 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1xmk ADAR the crystal structure of the zb domain from the rna editing enzyme adar1 0.97Å AUTH A.ATHANASIADIS,D.PLACIDO,S.MAAS,B.A.BROWN II,AUTH 2 K.LOWENHAUPT,A.RICHTITL THE CRYSTAL STRUCTURE OF THE Z[BETA] DOMAIN OF THETITL 2 RNA-EDITING ENZYME ADAR1 REVEALS DISTINCTTITL 3 CONSERVED SURFACES AMONG Z-DOMAINS.REF J.MOL.BIOL. V. 351 496 2005REFN ISSN 0022-2836PMID 16023667DOI 10.1016/J.JMB.2005.06.028 Variant Set […]
General Structure Information 4dgj TMPRSS15 structure of a human enteropeptidase light chain variant 1.9Å AUTH P.SIMEONOV,M.ZAHN,N.STRATER,T.ZUCHNERTITL CRYSTAL STRUCTURE OF A SUPERCHARGED VARIANT OF THE HUMANTITL 2 ENTEROPEPTIDASE LIGHT CHAIN.REF PROTEINS V. 80 1907 2012REFN ISSN 0887-3585PMID 22488687DOI 10.1002/PROT.24084 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3oe8 CXCR4 crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup 3.1Å AUTH B.WU,E.Y.CHIEN,C.D.MOL,G.FENALTI,W.LIU,V.KATRITCH,R.ABAGYAN,AUTH 2 A.BROOUN,P.WELLS,F.C.BI,D.J.HAMEL,P.KUHN,T.M.HANDEL,AUTH 3 V.CHEREZOV,R.C.STEVENSTITL STRUCTURES OF THE CXCR4 CHEMOKINE GPCR WITH SMALL-MOLECULETITL 2 AND CYCLIC PEPTIDE ANTAGONISTS.REF SCIENCE V. 330 1066 2010REFN ISSN 0036-8075PMID 20929726DOI 10.1126/SCIENCE.1194396 Variant Set Distributions […]
General Structure Information 2vqv HDAC4 structure of hdac4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor 3.3Å AUTH M.J.BOTTOMLEY,P.LO SURDO,P.DI GIOVINE,A.CIRILLO,AUTH 2 R.SCARPELLI,F.FERRIGNO,P.JONES,P.NEDDERMANN,AUTH 3 R.DE FRANCESCO,C.STEINKUHLER,P.GALLINARI,A.CARFITITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE HUMANTITL 2 HDAC4 CATALYTIC DOMAIN REVEALS A REGULATORYTITL 3 STRUCTURAL ZINC-BINDING DOMAIN.REF J.BIOL.CHEM. V. 283 26694 2008REFN ISSN 0021-9258PMID […]
General Structure Information 2leo SPINK7 solution structure of esophageal cancer-related gene 2 -1.0Å AUTH Y.FENG,Y.GENG,T.ZHOU,J.WANGTITL NMR STRUCTURE NOTE: HUMAN ESOPHAGEAL CANCER-RELATED GENE 2REF J.BIOMOL.NMR V. 53 65 2012REFN ISSN 0925-2738PMID 22528291DOI 10.1007/S10858-012-9622-9 Variant Set Distributions Mapped Variants
General Structure Information 1vyh PAFAH1B2 paf-ah holoenzyme: lis1/alfa2 3.4Å AUTH C.TARRICONE,F.PERRINA,S.MONZANI,L.MASSIMILIANO,AUTH 2 M.H.KIM,Z.S.DEREWENDA,S.KNAPP,L.-H.TSAI,A.MUSACCHIOTITL COUPLING PAF SIGNALING TO DYNEIN REGULATION:TITL 2 STRUCTURE OF LIS1 IN COMPLEX WITH PAF-TITL 3 ACETYLHYDROLASE.REF NEURON V. 44 809 2004REFN ISSN 0896-6273PMID 15572112DOI 10.1016/J.NEURON.2004.11.019 Variant Set Distributions Mapped Variants