Assessment of Structural Intolerance and Durability
General Structure Information 3sag EXOSC10 crystal structure of the human rrp6 catalytic domain with d313n mutation in the active site 2.7Å AUTH K.JANUSZYK,Q.LIU,C.D.LIMATITL ACTIVITIES OF HUMAN RRP6 AND STRUCTURE OF THE HUMAN RRP6TITL 2 CATALYTIC DOMAIN.REF RNA V. 17 1566 2011REFN ISSN 1355-8382PMID 21705430DOI 10.1261/RNA.2763111 Variant Set Distributions Mapped Variants
General Structure Information 2kie OCRL a ph domain within ocrl bridges clathrin mediated membrane trafficking to phosphoinositide metabolis -1.0Å AUTH Y.MAO,D.M.BALKIN,R.ZONCU,K.S.ERDMANN,L.TOMASINI,AUTH 2 F.HU,M.M.JIN,M.E.HODSDON,P.DE CAMILLITITL A PH DOMAIN WITHIN OCRL BRIDGES CLATHRIN-MEDIATEDTITL 2 MEMBRANE TRAFFICKING TO PHOSPHOINOSITIDE METABOLISMREF EMBO J. V. 28 1831 2009REFN ISSN 0261-4189PMID 19536138DOI 10.1038/EMBOJ.2009.155 Variant Set Distributions Mapped Variants
General Structure Information 3d59 PLA2G7 crystal structure of human plasma platelet activating factor acetylhydrolase 1.5Å AUTH U.SAMANTA,B.J.BAHNSONTITL CRYSTAL STRUCTURE OF HUMAN PLASMATITL 2 PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE:TITL 3 STRUCTURAL IMPLICATION TO LIPOPROTEIN BINDING ANDTITL 4 CATALYSIS.REF J.BIOL.CHEM. V. 283 31617 2008REFN ISSN 0021-9258PMID 18784071DOI 10.1074/JBC.M804750200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3ezz DUSP4 crystal structure of human mkp-2 2.9Å AUTH D.G.JEONG,S.K.JUNG,T.S.YOON,E.J.WOO,J.H.KIM,AUTH 2 B.C.PARK,S.E.RYU,S.J.KIMTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMANTITL 2 MKP-2 REVEALS A 24-MER ASSEMBLY.REF PROTEINS V. 76 763 2009REFN ISSN 0887-3585PMID 19415758DOI 10.1002/PROT.22423 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1wch PTPN13 crystal structure of ptpl1 human tyrosine phosphatase mutated in colorectal cancer – evidence for a second phosphotyrosine substrate recognition pocket 1.85Å AUTH F.VILLA,M.DEAK,G.B.BLOOMBERG,D.R.ALESSI,AUTH 2 D.M.F.VAN AALTENTITL CRYSTAL STRUCTURE OF PTPL1/FAP-1 HUMAN TYROSINETITL 2 PHOSPHATASE MUTATED IN COLORECTAL CANCER:TITL 3 EVEIDENCE FOR A SECOND PHOSPHOTYROSINE SUBSTRATETITL 4 RECOGNITION POCKETREF J.BIOL.CHEM. V. […]
General Structure Information 2ee5 ARHGAP5 solution structure of the n-teruminus extended rhogap domain from human rho gtpase activating protein 5 variant -1.0Å AUTH T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERUMINUS EXTENDEDTITL 2 RHOGAP DOMAIN FROM HUMAN RHO GTPASE ACTIVATINGTITL 3 PROTEIN 5 VARIANTREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3llm DHX9 crystal structure analysis of a rna helicase 2.8Å AUTH P.SCHUTZ,E.WAHLBERG,T.KARLBERG,M.HAMMARSTROM,R.COLLINS,AUTH 2 A.FLORES,H.SCHULERTITL CRYSTAL STRUCTURE OF HUMAN RNA HELICASE A (DHX9): STRUCTURALTITL 2 BASIS FOR UNSELECTIVE NUCLEOTIDE BASE BINDING IN A DEAD-BOXTITL 3 VARIANT PROTEIN.REF J.MOL.BIOL. V. 400 768 2010REFN ISSN 0022-2836PMID 20510246DOI 10.1016/J.JMB.2010.05.046 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2fh7 PTPRS crystal structure of the phosphatase domains of human ptp sigma 2.0Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2kmv ATP7A solution structure of the nucleotide binding domain of the human menkes protein in the atp-free form -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,S.INAGAKI,M.MIGLIARDI,AUTH 2 A.ROSATOTITL THE BINDING MODE OF ATP REVEALED BY THE SOLUTIONTITL 2 STRUCTURE OF THE N-DOMAIN OF HUMAN ATP7A.REF J.BIOL.CHEM. 2009REFN ESSN 1083-351XPMID 19917612DOI 10.1074/JBC.M109.054262 Variant Set Distributions Mapped Variants
General Structure Information 3g45 PDE4B crystal structure of human phosphodiesterase 4b with regulatory domain and d155988 2.63Å AUTH A.B.BURGIN,O.T.MAGNUSSON,J.SINGH,P.WITTE,AUTH 2 B.L.STAKER,J.M.BJORNSSON,M.THORSTEINSDOTTIR,AUTH 3 S.HRAFNSDOTTIR,T.HAGEN,A.S.KISELYOV,L.J.STEWART,AUTH 4 M.E.GURNEYTITL DESIGN OF PHOSPHODIESTERASE 4D (PDE4D) ALLOSTERICTITL 2 MODULATORS FOR ENHANCING COGNITION WITH IMPROVEDTITL 3 SAFETY.REF NAT.BIOTECHNOL. V. 28 63 2010REFN ISSN 1087-0156PMID 20037581DOI 10.1038/NBT.1598 Variant Set Distributions Ripley’s K Analysis […]