Assessment of Structural Intolerance and Durability
General Structure Information 4gnk PLCB3 crystal structure of galphaq in complex with full-length human plcbeta3 4.0Å AUTH A.M.LYON,S.DUTTA,C.A.BOGUTH,G.SKINIOTIS,J.J.TESMERTITL FULL-LENGTH G ALPHA (Q)-PHOSPHOLIPASE C-BETA 3 STRUCTURETITL 2 REVEALS INTERFACES OF THE C-TERMINAL COILED-COIL DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 20 355 2013REFN ISSN 1545-9993PMID 23377541DOI 10.1038/NSMB.2497 Variant Set Distributions Mapped Variants
General Structure Information 4gnk PLCB3 crystal structure of galphaq in complex with full-length human plcbeta3 4.0Å AUTH A.M.LYON,S.DUTTA,C.A.BOGUTH,G.SKINIOTIS,J.J.TESMERTITL FULL-LENGTH G ALPHA (Q)-PHOSPHOLIPASE C-BETA 3 STRUCTURETITL 2 REVEALS INTERFACES OF THE C-TERMINAL COILED-COIL DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 20 355 2013REFN ISSN 1545-9993PMID 23377541DOI 10.1038/NSMB.2497 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3l5k HDHD1 the crystal structure of human haloacid dehalogenase-like hydrolase domain containing 1a (hdhd1a) 2.0Å AUTH E.UGOCHUKWU,K.GUO,S.PICAUD,J.MUNIZ,C.ALLERSTON,AUTH 2 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,W.W.YUE,K.L.KAVANAGH,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF HUMAN HALOACIDTITL 2 DEHALOGENASE-LIKE HYDROLASE DOMAIN CONTAINING 1ATITL 3 (HDHD1A)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3l5k HDHD1 the crystal structure of human haloacid dehalogenase-like hydrolase domain containing 1a (hdhd1a) 2.0Å AUTH E.UGOCHUKWU,K.GUO,S.PICAUD,J.MUNIZ,C.ALLERSTON,AUTH 2 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,W.W.YUE,K.L.KAVANAGH,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF HUMAN HALOACIDTITL 2 DEHALOGENASE-LIKE HYDROLASE DOMAIN CONTAINING 1ATITL 3 (HDHD1A)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3l5k HDHD1 the crystal structure of human haloacid dehalogenase-like hydrolase domain containing 1a (hdhd1a) 2.0Å AUTH E.UGOCHUKWU,K.GUO,S.PICAUD,J.MUNIZ,C.ALLERSTON,AUTH 2 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,W.W.YUE,K.L.KAVANAGH,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF HUMAN HALOACIDTITL 2 DEHALOGENASE-LIKE HYDROLASE DOMAIN CONTAINING 1ATITL 3 (HDHD1A)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1so2 PDE3B catalytic domain of human phosphodiesterase 3b in complex with a dihydropyridazine inhibitor 2.4Å AUTH G.SCAPIN,S.B.PATEL,C.CHUNG,J.P.VARNERIN,AUTH 2 S.D.EDMONDSON,A.MASTRACCHIO,E.R.PARMEE,S.B.SINGH,AUTH 3 J.W.BECKER,L.H.VAN DER PLOEG,M.R.TOTATITL CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 3B:TITL 2 ATOMIC BASIS FOR SUBSTRATE AND INHIBITORTITL 3 SPECIFICITYREF BIOCHEMISTRY V. 43 6091 2004REFN ISSN 0006-2960PMID 15147193DOI 10.1021/BI049868I Variant Set Distributions Ripley’s K […]
General Structure Information 1ywh PLAUR crystal structure of urokinase plasminogen activator receptor 2.7Å AUTH P.LLINAS,M.H.LE DU,H.GARDSVOLL,K.DANO,M.PLOUG,B.GILQUIN,AUTH 2 E.A.STURA,A.MENEZTITL CRYSTAL STRUCTURE OF THE HUMAN UROKINASE PLASMINOGENTITL 2 ACTIVATOR RECEPTOR BOUND TO AN ANTAGONIST PEPTIDEREF EMBO J. V. 24 1655 2005REFN ISSN 0261-4189PMID 15861141DOI 10.1038/SJ.EMBOJ.7600635 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4i5k PPP2R3A pp2a pr70 holoenzyme model3_dica_rcsb.pdb bppnat5_extend.mtz 2.9Å AUTH N.WLODARCHAK,F.GUO,K.A.SATYSHUR,L.JIANG,P.D.JEFFREY,T.SUN,AUTH 2 V.STANEVICH,M.C.MUMBY,Y.XINGTITL STRUCTURE OF THE CA(2+)-DEPENDENT PP2A HETEROTRIMER ANDTITL 2 INSIGHTS INTO CDC6 DEPHOSPHORYLATION.REF CELL RES. V. 23 931 2013REFN ISSN 1001-0602PMID 23752926DOI 10.1038/CR.2013.77 Variant Set Distributions Mapped Variants
General Structure Information 2y6e USP4 structure of the d1d2 domain of usp4, the conserved catalytic domain 2.4Å AUTH M.CLERICI,M.P.A.LUNA-VARGAS,A.C.FAESEN,T.K.SIXMATITL THE DUSP-UBL DOMAIN OF USP4 ENHANCES ITS CATALYTICTITL 2 EFFICIENCY BY PROMOTING UBIQUITIN EXCHANGE.REF NAT.COMMUN. V. 5 5399 2014REFN ISSN 2041-1723PMID 25404403DOI 10.1038/NCOMMS6399 Variant Set Distributions Mapped Variants
General Structure Information 3q90 G3BP1 crystal structure of the ntf2 domain of ras gtpase-activating protein- binding protein 1 1.7Å AUTH M.WELIN,L.TRESAUGUES,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,T.EKBLAD,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE NTF2 DOMAIN OF RASTITL 2 GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]