Assessment of Structural Intolerance and Durability
General Structure Information 3pja TSN crystal structure of human c3po complex 3.0Å AUTH X.YE,N.HUANG,Y.LIU,Z.PAROO,C.HUERTA,P.LI,S.CHEN,Q.LIU,AUTH 2 H.ZHANGTITL STRUCTURE OF C3PO AND MECHANISM OF HUMAN RISC ACTIVATION.REF NAT.STRUCT.MOL.BIOL. V. 18 650 2011REFN ISSN 1545-9993PMID 21552258DOI 10.1038/NSMB.2032 Variant Set Distributions Mapped Variants
General Structure Information 3i4u DHX8 crystal structure analysis of a helicase associated domain 2.1Å AUTH D.KUDLINZKI,A.SCHMITT,H.CHRISTIAN,R.FICNERTITL STRUCTURAL ANALYSIS OF THE C-TERMINAL DOMAIN OF THETITL 2 SPLICEOSOMAL HELICASE PRP22REF BIOL.CHEM. V. 393 1131 2012REFN ISSN 1431-6730PMID 23096351DOI 10.1515/HSZ-2012-0158 Variant Set Distributions Mapped Variants
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2e1e WRN crystal structure of the hrdc domain of human werner syndrome protein, wrn 2.3Å AUTH K.KITANO,N.YOSHIHARA,T.HAKOSHIMATITL CRYSTAL STRUCTURE OF THE HRDC DOMAIN OF HUMAN WERNERTITL 2 SYNDROME PROTEIN, WRNREF J.BIOL.CHEM. V. 282 2717 2007REFN ISSN 0021-9258PMID 17148451DOI 10.1074/JBC.M610142200 Variant Set Distributions Mapped Variants
General Structure Information 2bzl PTPN14 crystal structure of the human protein tyrosine phosphatase n14 at 1.65 a resolution 1.65Å AUTH A.J.BARR,J.E.DEBRECZENI,J.ESWARAN,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINETITL 2 PHOSPHATASE 14 (PTPN14) AT 1.65-A RESOLUTION.REF PROTEINS V. 63 1132 2006REFN ISSN 0887-3585PMID 16534812DOI 10.1002/PROT.20958 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1zkl PDE7A multiple determinants for inhibitor selectivity of cyclic nucleotide phosphodiesterases 1.67Å AUTH H.WANG,Y.LIU,Y.CHEN,H.ROBINSON,H.KETITL MULTIPLE ELEMENTS JOINTLY DETERMINE INHIBITORTITL 2 SELECTIVITY OF CYCLIC NUCLEOTIDETITL 3 PHOSPHODIESTERASES 4 AND 7REF J.BIOL.CHEM. V. 280 30949 2005REFN ISSN 0021-9258PMID 15994308DOI 10.1074/JBC.M504398200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2eqs DHX8 solution structure of the s1 rna binding domain of human atp-dependent rna helicase dhx8 -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE S1 RNA BINDING DOMAIN OFTITL 2 HUMAN ATP-DEPENDENT RNA HELICASE DHX8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2d07 TDG crystal structure of sumo-3-modified thymine-dna glycosylase 2.1Å AUTH D.BABA,N.MAITA,J.G.JEE,Y.UCHIMURA,H.SAITOH,AUTH 2 K.SUGASAWA,F.HANAOKA,H.TOCHIO,H.HIROAKI,M.SHIRAKAWATITL CRYSTAL STRUCTURE OF SUMO-3-MODIFIED THYMINE-DNATITL 2 GLYCOSYLASEREF J.MOL.BIOL. V. 359 137 2006REFN ISSN 0022-2836PMID 16626738DOI 10.1016/J.JMB.2006.03.036 Variant Set Distributions Mapped Variants