General Structure Information
| PDB ID | 1zkl |
| HGNC Gene Label(s) | PDE7A |
| Structure Name | multiple determinants for inhibitor selectivity of cyclic nucleotide phosphodiesterases |
| Resolution | 1.67Å |
| Reference | AUTH H.WANG,Y.LIU,Y.CHEN,H.ROBINSON,H.KETITL MULTIPLE ELEMENTS JOINTLY DETERMINE INHIBITORTITL 2 SELECTIVITY OF CYCLIC NUCLEOTIDETITL 3 PHOSPHODIESTERASES 4 AND 7REF J.BIOL.CHEM. V. 280 30949 2005REFN ISSN 0021-9258PMID 15994308DOI 10.1074/JBC.M504398200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 317 |
| Number Of SNVs | 57 |
| Number Of Permutations | 6886 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.078 |
| p-value | 0.178 |
COSMIC
| Number Of Residues | 317 |
| Number Of SNVs | 4 |
| Number Of Permutations | 898 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.167 |
| p-value | 0.771 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 57 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | -0.27 |
| p-value | 0.621 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
